The DOI matches its Crossref record; 114 of the 115 references it cites were found in a registry or an index.
Glucocorticoid therapy in neurologic critical care
Abstract
BACKGROUND: The pivotal role of inflammation and edema across the spectrum of central nervous system injury has driven extensive investigation into the therapeutic potential of glucocorticoids. OBJECTIVE: To review the experimental and clinical data relating to the efficacy and adverse effects of glucocorticoids in conditions encountered in critical neurologic and neurosurgical illness. DATA SOURCE: Search of MEDLINE and Cochrane databases, manual review of article bibliographies. DATA SYNTHESIS AND CONCLUSIONS: The efficacy of glucocorticoids is well established in ameliorating edema associated with brain tumors and in improving outcome in subsets of patients with bacterial meningitis. Despite frequently encouraging experimental results, clinical trials of glucocorticoids in ischemic stroke, intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and traumatic brain injury have not shown a definite therapeutic effect. The evidence supporting glucocorticoid therapy for spinal cord injury is controversial; however methylprednisolone continues to be widely employed in this setting.
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“While there is widespread use of GCs in clinical neurology to control CNS inflammation in general and poststroke edema in particular, such interventions are often ineffective and can even worsen clinical outcome (Gomes et al., 2005).”
From The Stressed CNS: When Glucocorticoids Aggravate Inflammation (2009) · cites this paper as Gomes et al., 2005
Citations
Cites
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Annane, D. (2002) · JAMA · doi:10.1001/jama.288.7.862 · Cited by 3,075
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
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Dexamethasone in Adults with Bacterial Meningitis
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Cited by
Sorted by citations
An inflammatory review of glucocorticoid actions in the CNS
Sorrells, S. F., & Sapolsky, R. M. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.11.006 · Cited by 461
The Stressed CNS: When Glucocorticoids Aggravate Inflammation
Sorrells, S. F., Caso, J. R., Munhoz, C. D., & Sapolsky, R. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.032 · Cited by 425
Microglial Activation in Stroke: Therapeutic Targets
Yenari, M. A., Kauppinen, T. M., & Swanson, R. A. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.005 · Cited by 398
A review of progress in understanding the pathophysiology and treatment of brain edema
Marmarou, A. (2007) · Neurosurgical FOCUS · doi:10.3171/foc.2007.22.5.2 · Cited by 333
Progesterone exerts neuroprotective effects after brain injury
Stein, D. G. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.012 · Cited by 294
Metadata
- Authors
- Gomes, J. A., Stevens, R. D., Lewin, J. J., Mirski, M. A., & Bhardwaj, A.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Critical Care Medicine
- Published
- 2005-06
- Volume
- 33
- Issue
- 6
- Pages
- 1214-1224
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2073207619
- Cited by
- 118
- References
- 115
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS046379, R01NS046379)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, cerebral edema, inflammation, brain tumors, bacterial meningitis, ischemic stroke, intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, traumatic brain injury, spinal cord injury, methylprednisolone, adverse effects
- MeSH terms
- Brain Edema, Brain Neoplasms, Central Nervous System Diseases, Central Nervous System Infections, Cerebrovascular Disorders, Glucocorticoids, Humans, Myasthenia Gravis, Trauma, Nervous System
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