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Cited by 150Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesChild and Adolescent Psychosocial and Emotional Development

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Effects of Long-Term Atomoxetine Treatment for Young Children With Attention-Deficit/Hyperactivity Disorder

KRATOCHVIL, CHRISTOPHER J., WILENS, TIMOTHY E., GREENHILL, LAURENCE L., GAO, HAITAO, BAKER, KURT D., FELDMAN, PETER D., GELOWITZ, DOUGLAS L.·2006·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1097/01.chi.0000222788.34229.68
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Abstract

Objective The purpose of this 13-study (seven double-blind/placebo-controlled, six open-label) meta-analysis is to determine the effectiveness and tolerability of long-term atomoxetine treatment among young children with attention-deficit/hyperactivity disorder (ADHD).Method Data were pooled from 6- and 7-year-olds (N = 272) who met DSM-IV criteria for ADHD, received atomoxetine treatment, and were enrolled in clinical trials of > or =2 years. Of these, 97 subjects reached the 24-month time point, providing data for long-term trend analysis of safety and effectiveness.Results Effectiveness for most subjects was maintained over long-term treatment, as demonstrated by total scores and total T scores on the Attention-Deficit/Hyperactivity Disorder Rating Scale-IV-Parent Version, investigator administered and scored. During the 2-year period, 25.7% discontinued because of lack of effectiveness, but adverse events were clinically minor and transient, and only 4.0% of children discontinued because of an adverse event. Notable effects on growth were seen during early phases of the study, with attenuation occurring by the 2-year time point. Statistically significant increases in pulse and blood pressure and decreases in cardiac PR interval were seen, but no changes were deemed both statistically significant and clinically meaningful among any vital signs, electrocardiographic measures, or laboratory tests.Conclusion Long-term atomoxetine treatment appears generally well tolerated and effective in the treatment of young children with ADHD.

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Crossref · 10.1097/01.chi.0000222788.34229.68

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Research works printed but not linked: 6

  1. Allen, 2002, Safety and efficacy of atomoxetine in pediatric CYP2D6 extensive vs. poor metabolizers, Biol Psychiatry, 51, 37S
  2. Spencer TJ (2003), Treatment for ADHD with OROS methylphenidate: long-term effect on growth. Proceedings Summary of the 156th Annual Meeting of the American Psychiatric Association, San Francisco, May 17-22, p 268
  3. Sutton V, Milton D, Ruff D, Allen AJ (2004a), Atomoxetine efficacy over time in children and adolescents with ADHD. In: Scientific Proceedings of the 51st Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Washington, D C, October 19-24, p 157
  4. Sutton V, Milton D, Ruff D, Allen AJ (2004b), Long term effects of atomoxetine on growth in children with ADHD. In: Scientific Proceedings of the 51st Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Washington, DC, October 19-24, p 132
  5. Wernicke JF, Kratochvil C, Milton D et al. (2002), Long-term safety of atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder. In: Proceedings Summary of the 155th Annual Meeting of the American Psychiatric Association, Philadelphia, May 18-23, p 92
  6. Wigal SB, Steinhoff K, McGough JJ et al. (2004), Analog classroom study of amphetamine XR and atomoxetine for ADHD. In: Scientific Proceedings of the 51st Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Washington, DC, October 19-24, p 135

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Metadata

Authors
KRATOCHVIL, C. J., WILENS, T. E., GREENHILL, L. L., GAO, H., BAKER, K. D., FELDMAN, P. D., & GELOWITZ, D. L.
Affiliations
Harvard University (US)
Corresponding author
KRATOCHVIL, CHRISTOPHER J.
ORCID
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
2006-08
Volume
45
Issue
8
Pages
919-927
ISSN
0890-8567 (ISSN-L)
DOI
10.1097/01.chi.0000222788.34229.68
OpenAlex
W1965946834
Cited by
150
References
37
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 6
FWCI
2.39
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
atomoxetine, attention deficit hyperactivity disorder, young children, long-term treatment, treatment effectiveness, tolerability, adverse events, growth, blood pressure, pulse rate, ADHD Rating Scale-IV
MeSH terms
Atomoxetine Hydrochloride, Attention Deficit Disorder with Hyperactivity, Child, Female, Humans, Male, Propylamines, Time Factors, Adrenergic Uptake Inhibitors

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