The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
The problem of non-response to cardiac resynchronization therapy
Abstract
PURPOSE OF REVIEW: Cardiac resynchronization therapy improves quality of life, exercise performance, left ventricular ejection fraction, and reduces heart failure hospitalizations and mortality in patients with New York Heart Association class III or IV congestive heart failure and intraventricular conduction delay. A number of key clinical research questions remain, perhaps most importantly the issue of why apparently suitable patients do not respond to cardiac resynchronization therapy. These issues are also relevant to patients who do respond to cardiac resynchronization therapy as potentially their response might be further increased. This article will review the data regarding the frequency of the problem of non-response to cardiac resynchronization therapy and then discuss the postulated reasons and potential solutions. RECENT FINDINGS: Rates of non-response to cardiac resynchronization therapy are often quoted as 20-30%, but a critical analysis of the data would suggest the true non-responder rate can be estimated as perhaps 40-50%. The data indicate that on a population basis non-response is multi-factorial and the extent of mechanical dyssynchrony, left ventricular pacing site and cause of congestive heart failure are likely to be important. Ongoing research is exploring the utility of various techniques for quantifying mechanical dyssynchrony and the potential benefits of targeted left ventricular lead placement and post-implant optimization. SUMMARY: Cardiac resynchronization therapy is a major breakthrough in treatment for advanced congestive heart failure patients. There is substantial rate of non-response to this therapy, however, and research is exploring various ways to increase the response to the technique.
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Cites
The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure
Cleland, J. G. F., Daubert, J.-C., Erdmann, E., Freemantle, N., Gras, D., Kappenberger, L., & Tavazzi, L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050496 · Cited by 6,276
Bristow, M. R., Saxon, L. A., Boehmer, J., Krueger, S., Kass, D. A., De Marco, T., Carson, P., DiCarlo, L., DeMets, D., White, B. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032423 · Cited by 5,812
Cardiac Resynchronization in Chronic Heart Failure
Abraham, W. T., Fisher, W. G., Smith, A. L., Delurgio, D. B., Leon, A. R., Loh, E., Kocovic, D. Z., Packer, M., Clavell, A. L., Hayes, D. L., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013168 · Cited by 4,648
CARDIAC RESYNCHRONIZATION IN CHRONIC HEART FAILURE
Braham, W. I. T. A., Isher, W. E. G. F., Mith, L. S., Elurgio, D. A. B. D., Eon, A. N. R. L., Oh, E., Ocovic, D. U. Z. K., Acker, M. G., Lavell, L. C., Ayes, D. A. L. H., et al. (2002) · Cited by 3,808
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St John Sutton, M. G., Plappert, T., Abraham, W. T., Smith, A. L., DeLurgio, D. B., Leon, A. R., Loh, E., Kocovic, D. Z., Fisher, W. G., Ellestad, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000065226.24159.e9 · Cited by 1,124
Yu, C.-M., Chau, E., Sanderson, J. E., Fan, K., Tang, M.-O., Fung, W.-H., Lin, H., Kong, S.-L., Lam, Y.-M., Hill, M. R. S., et al. (2002) · Circulation · doi:10.1161/hc0402.102623 · Cited by 1,110
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Cardiac resynchronization therapy tailored by echocardiographic evaluation of ventricular asynchrony
Pitzalis, M. V., Iacoviello, M., Romito, R., Massari, F., Rizzon, B., Luzzi, G., Guida, P., Andriani, A., Mastropasqua, F., & Rizzon, P. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02337-9 · Cited by 716
Yu, C.-M., Bleeker, G. B., Fung, J. W.-H., Schalij, M. J., Zhang, Q., van der Wall, E. E., Chan, Y.-S., Kong, S.-L., & Bax, J. J. (2005) · Circulation · doi:10.1161/circulationaha.105.538272 · Cited by 705
Metadata
- Authors
- Birnie, D. H., & Tang, A. S.
- Venue
- Current Opinion in Cardiology
- Published
- 2006-01
- Volume
- 21
- Issue
- 1
- Pages
- 20-26
- ISSN
- 0268-4705 (ISSN-L)
- OpenAlex
- W2068989566
- Cited by
- 277
- References
- 47
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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