The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Child Mortality According to Maternal and Infant HIV Status in Zimbabwe
Abstract
BACKGROUND: HIV causes substantial mortality among African children but there is limited data on how this is influenced by maternal or infant infection status and timing. METHODS: Children enrolled in the ZVITAMBO trial were divided into 5 groups: those born to HIV-negative mothers (NE, n = 9510), those born to HIV-positive mothers but noninfected (NI, n = 3135), those infected in utero (IU, n = 381), those infected intrapartum (IP, n = 508), and those infected postnatally (PN, n = 258). Their mortality was estimated. RESULTS: Two-year mortality was 2.9% (NE infants), 9.2% (NI), 67.5% (IU), 65.1% (IP), and 33.2% (PN). Between 8 weeks and 6 months, mortality in IU infants quintupled (from 309 to 1686/1000 c-y). The median time from infection to death was 208, 380, and >500 days for IU, IP, and PN infants, respectively. Among NI children, advanced maternal disease was predictive of mortality. Acute respiratory infection was the major cause of death. CONCLUSIONS: Perinatally infected infants are at particular risk of death between 2 and 6 months: cotrimoxazole prophylaxis and early pediatric HAART should be scaled up. Uninfected infants of infected mothers have at least twice the mortality risk of infants born to uninfected mothers: all HIV-exposed infants should be targeted with child survival interventions. HIV-positive mothers with more advanced disease are not only more likely to infect their infants, but their infants are more likely to die, whether infected or not: provision of antiretroviral treatment to pregnant and lactating women is an urgent need for both mothers and their children.
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A simplified method for diagnosis of gestational age in the newborn infant
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Self-citationMiller, M. F., Humphrey, J. H., Iliff, P. J., Malaba, L. C., Mbuya, N. V., the ZVITAMBO Study Group, & Stoltzfus, R. J. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-1 · Cited by 200
Self-citationHumphrey, J. H., Iliff, P. J., Marinda, E. T., Mutasa, K., Moulton, L. H., Chidawanyika, H., Ward, B. J., Nathoo, K. J., Malaba, L. C., Zijenah, L. S., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/500366 · Cited by 200
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Clinical presentation and outcome of Pneumocystis carinii pneumonia in Malawian children
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Sex Differences in Pediatric Infectious Diseases
Muenchhoff, M., & Goulder, P. J. R. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu232 · Cited by 406
HIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination
Evans, C., Jones, C. E., & Prendergast, A. J. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00055-4 · Cited by 285
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Metadata
- Authors
- Marinda, E., Humphrey, J. H., Iliff, P. J., Mutasa, K., Nathoo, K. J., Piwoz, E. G., Moulton, L. H., Salama, P., & Ward, B. J.
- Venue
- Pediatric Infectious Disease Journal
- Published
- 2007-06
- Volume
- 26
- Issue
- 6
- Pages
- 519-526
- ISSN
- 0891-3668 (ISSN-L)
- OpenAlex
- W2017442023
- Cited by
- 314
- References
- 14
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- closed
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