The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Sex Differences in Pediatric Infectious Diseases
Open accessAbstract
The success of the immune response is finely balanced between, on the one hand, the need to engage vigorously with, and clear, certain pathogens; and, on the other, the requirement to minimize immunopathology and autoimmunity. Distinct immune strategies to achieve this balance have evolved in females and males and also in infancy through to adulthood. Sex differences in outcome from a range of infectious diseases can be identified from as early as fetal life, such as in congenital cytomegalovirus infection. The impact of sex hormones on the T-helper 1/T-helper 2 cytokine balance has been proposed to explain the higher severity of most infectious diseases in males. In the minority where greater morbidity and mortality is observed in females, this is hypothesized to arise because of greater immunopathology and/or autoimmunity. However, a number of unexplained exceptions to this rule are described. Studies that have actually measured the sex differences in children in the immune responses to infectious diseases and that would further test these hypotheses, are relatively scarce.
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Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61728-0 · Cited by 14,070
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Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728 · cited 2×
“terleukin 1b, in response to unrelated bacterial and fungal pathogens [57].”
BackgroundSex-specific genetic architecture of human disease
Ober, C., Loisel, D. A., & Gilad, Y. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2415 · Cited by 787
Cited by
Nielsen-Saines, K., Brasil, P., Kerin, T., Vasconcelos, Z., Gabaglia, C. R., Damasceno, L., Pone, M., Abreu de Carvalho, L. M., Pone, S. M., Zin, A. A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0496-1 · Cited by 268
Scott, S., Kendall, L., Gomez, P., Howie, S. R. C., Zaman, S. M. A., Ceesay, S., D’Alessandro, U., & Jasseh, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172286 · Cited by 31
Metadata
- Authors
- Muenchhoff, M., & Goulder, P. J. R.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-06-25
- Volume
- 209
- Issue
- suppl 3
- Pages
- S120-S126
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2113439238
- Cited by
- 406
- References
- 5
- FWCI
- 18.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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