The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Understanding osteosarcomas.
Abstract
This article reviews the cause, clinical presentation, diagnostic methods, and management of osteosarcoma, the most common primary bone tumor and third most common cancer among children and adolescents. In the 1970s, the introduction of adjuvant chemotherapy following tumor resection improved overall 10-year survival from 30% to about 50% of patients. However, since that change in management strategy, the survival rate has since plateaued, with no improvement in overall 10-year survival since the 1990s. A better understanding of this disease is the first step to help improve these numbers.
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In the citing paper
“Osteosarcoma recurs in 30% to 40% of patients with localized disease and 80% of those with metastatic disease”
From Lenvatinib Plus Ifosfamide and Etoposide in Children and Young Adults With Relapsed Osteosarcoma (2024) · cites this paper as [6]
Citations
Cites
Osteosarcoma treatment – Where do we stand? A state of the art review
Luetke, A., Meyers, P. A., Lewis, I., & Juergens, H. (2014) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.11.006 · Cited by 1,234
Mirabello, L., Troisi, R. J., & Savage, S. A. (2009) · International Journal of Cancer · doi:10.1002/ijc.24320 · Cited by 791
Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand?
Anninga, J. K., Gelderblom, H., Fiocco, M., Kroep, J. R., Taminiau, A. H. M., Hogendoorn, P. C. W., & Egeler, R. M. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.05.030 · Cited by 456
Radiotherapy for local control of osteosarcoma
DeLaney, T. F., Park, L., Goldberg, S. I., Hug, E. B., Liebsch, N. J., Munzenrider, J. E., & Suit, H. D. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.05.051 · Cited by 306
Berner, K., Johannesen, T. B., Berner, A., Haugland, H. K., Bjerkehagen, B., Bøhler, P. J., & Bruland, Ø. S. (2014) · Acta Oncologica · doi:10.3109/0284186x.2014.923934 · Cited by 135
Imran, H., Enders, F., Krailo, M., Sim, F. H., Okuno, S. H., Hawkins, D. S., Neglia, J. P., Randall, R. L., Womer, R. B., Mascarenhas, L., et al. (2009) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.h.00449 · Cited by 61
Riel, C. V., van den Bergh, E. M. , Kemps, H., Feuth, T. B., Schreuder, H. W. B., Hoogerbrugge, P. M., de Groot, I. J. M., & Mavinkurve‐Groothuis, A. M. C. (2014) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2014.01.005 · Cited by 30
Shimose, S., Kubo, T., Fujimori, J., Furuta, T., & Ochi, M. (2014) · Journal of Orthopaedic Science · doi:10.1007/s00776-014-0617-0 · Cited by 20
High tumor volume and local recurrence following surgery in osteosarcoma: A retrospective study
Poudel, R. R., Kumar, V. S., Bakhshi, S., Gamanagatti, S. R., Rastogi, S., & Khan, S. A. (2014) · Indian Journal of Orthopaedics · doi:10.4103/0019-5413.132520 · Cited by 19
Serpick, A. A. (1984) · Journal of the American Podiatric Medical Association · doi:10.7547/87507315-74-7-355 · Cited by 2
Research works printed but not linked: 1
- Baker, 2008, Bone tumors: primary and metastatic bone lesions, Cecil Medicine, 1520
Cited by
Osteosarcoma: a review of current and future therapeutic approaches
Zhao, X., Wu, Q., Gong, X., Liu, J., & Ma, Y. (2021) · BioMedical Engineering OnLine · doi:10.1186/s12938-021-00860-0 · Cited by 312
Belayneh, R., Fourman, M. S., Bhogal, S., & Weiss, K. R. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01053-7 · Cited by 223
Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges
Gao, X., Li, L., Cai, X., Huang, Q., Xiao, J., & Cheng, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120404 · Cited by 183
Liao, J., Shi, K., Jia, Y., Wu, Y., & Qian, Z. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.006 · Cited by 181
Drug Resistance in Osteosarcoma: Emerging Biomarkers, Therapeutic Targets and Treatment Strategies
Hattinger, C. M., Patrizio, M. P., Fantoni, L., Casotti, C., Riganti, C., & Serra, M. (2021) · Cancers · doi:10.3390/cancers13122878 · Cited by 112
Metadata
- Authors
- Simpson, E., & Brown, H. L.
- Affiliations
- Mercer University (US)
- Venue
- JAAPA
- Published
- 2018-08
- Volume
- 31
- Issue
- 8
- Pages
- 15-19
- ISSN
- 0893-7400 (ISSN-L)
- 1547-1896
- OpenAlex
- W4248865982
- Cited by
- 233
- References
- 10
- Citations by year
- 2026: 4 · 2025: 21 · 2024: 47 · 2023: 45 · 2022: 36 · 2021: 38 · 2020: 27 · 2019: 13
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAAPA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Keywords
- osteosarcoma, primary bone tumors, childhood cancer, adjuvant chemotherapy, tumor resection, survival rate, clinical features, diagnosis, etiology
- MeSH terms
- Bone Neoplasms, Humans, Neoplasm Recurrence, Local, Osteosarcoma, Chemotherapy, Adjuvant, Neoadjuvant Therapy
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Understanding osteosarcomas. https://app.cochat.ai/papers/10.1097/01.jaa.0000541477.24116.8d
- The paper
- Simpson, E., & Brown, H. L. (2018). Understanding osteosarcomas. JAAPA. https://doi.org/10.1097/01.jaa.0000541477.24116.8d
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
