The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Osteosarcoma: a review of current and future therapeutic approaches
Open accessAbstract
Osteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extremely high mortality rate; it is considered as a serious threat to the human health globally. The incidence of OS is common in the metaphysis of long tubular bones, but rare in the spine, pelvis, and sacrum areas; moreover, majority of the OS patients present with only a single lesion. OS has a bimodal distribution pattern, that is, its incidence peaks in the second decade of life and in late adulthood. We examine historical and current literature to present a succinct review of OS. In this review, we have discussed the types, clinical diagnosis, and modern and future treatment methods of OS. The purpose of this article is to inspire new ideas to develop more effective therapeutic options.
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Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.776 · Cited by 2,393
Mirabello, L., Troisi, R. J., & Savage, S. A. (2009) · Cancer · doi:10.1002/cncr.24121 · Cited by 2,199
Mirabello, L., Troisi, R. J., & Savage, S. A. (2009) · International Journal of Cancer · doi:10.1002/ijc.24320 · Cited by 791
Common Musculoskeletal Tumors of Childhood and Adolescence
Arndt, C. A. S., & Crist, W. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907293410507 · Cited by 657
Update on Survival in Osteosarcoma
Anderson, M. E. (2016) · Orthopedic Clinics of North America · doi:10.1016/j.ocl.2015.08.022 · Cited by 560
Osteosarcoma: Anatomic and Histologic Variants
Klein, M. J., & Siegal, G. P. (2006) · American Journal of Clinical Pathology · doi:10.1309/uc6kqhld9lv2kenn · Cited by 386
Meyers, P. A., & Gorlick, R. (1997) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70540-x · Cited by 299
Common Musculoskeletal Tumors of Childhood and Adolescence
Arndt, C. A. S., Rose, P. S., Folpe, A. L., & Laack, N. N. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.01.015 · Cited by 298
Simpson, E., & Brown, H. L. (2018) · JAAPA · doi:10.1097/01.jaa.0000541477.24116.8d · Cited by 233
Cited by
Cellular crosstalk in the bone marrow niche
Huang, Z., Iqbal, Z., Zhao, Z., Liu, J., Alabsi, A. M., Shabbir, M., Mahmood, A., Liang, Y., Li, W., & Deng, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05900-6 · Cited by 34
Self-citationDong, C., Wang, Z., Shen, P., Chen, Y., Wang, J., & Wang, H. (2022) · Bioengineered · doi:10.1080/21655979.2022.2051805 · Cited by 25
Metadata
- Authors
- Zhao, X., Wu, Q., Gong, X., Liu, J., & Ma, Y.
- Venue
- BioMedical Engineering OnLine
- Published
- 2021-03-02
- Volume
- 20
- Issue
- 1
- Pages
- 24-24
- ISSN
- 1475-925X (ISSN-L)
- OpenAlex
- W3133782202
- Cited by
- 312
- References
- 9
- FWCI
- 29.79
- Type
- journal article
- Language
- en
- Open access
- gold
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