DIETARY OXALATE LOADS AND RENAL OXALATE HANDLING
Abstract
PURPOSE: Dietary oxalate makes a significant contribution to urinary oxalate excretion and, thus, may have a role in calcium oxalate kidney stone formation. Studies have indicated that the ingestion of oxalate rich foods results in transient increases in plasma oxalate concentrations and urinary oxalate excretion. We examined changes in plasma and urinary oxalate following oral crystalline oxalate loading under controlled dietary conditions to further define the renal handling of oxalate by normal adults. MATERIALS AND METHODS: Six normal adult subjects consumed controlled diets of known oxalate content for 1 week before ingesting loads of 0, 2, 4 and 8 mmol of oxalate. Urinary and plasma changes were measured to assess renal oxalate handling. Urinary excretion of proximal tubule derived enzymes and isoprostanes was monitored to assess for renal injury and oxidative stress. RESULTS: Time and dose dependent changes in plasma oxalate, urinary oxalate and in the clearance ratio of oxalate-to-creatinine were observed. A significant correlation (r=0.43, p <0.001) between the oxalate-to-creatinine clearance ratio and plasma oxalate levels was identified. No changes in urinary markers of oxidative stress or renal injury were observed following the 8 mmol oxalate load. CONCLUSIONS: Oxalate is rapidly absorbed and cleared by the kidney by filtration and secretion following an oral oxalate load. Renal oxalate secretion has a significant role in the renal handling of an oral oxalate load. There is no evidence of acute renal injury or oxidative stress with oral oxalate loads in these experimental conditions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Although dietary oxalate with high bioavailability increases plasma and urine levels, excreted oxalate is minimally dependent on diet in an epidemiological cohort.
“Although dietary oxalate with high bioavailability increases plasma and urine levels (29), excreted oxalate is minimally dependent on diet in an epidemiological cohort (30).”
From Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt (2015) · cites this paper as [29]
Cites
Contribution of dietary oxalate to urinary oxalate excretion
Holmes, R. P., Goodman, H. O., & Assimos, D. G. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00488.x · Cited by 502 · see citing works
Self-citationEstimation of the oxalate content of foods and daily oxalate intake
Holmes, R. P., & Kennedy, M. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00010.x · Cited by 264 · see citing works
Self-citationCalcium oxalate stone disease: role of lipid peroxidation and antioxidants
Selvam, R. (2002) · Urological Research · doi:10.1007/s00240-001-0228-z · Cited by 213 · see citing works
Li, H., Lawson, J. A., Reilly, M. P., Adiyaman, M., Hwang, S., Rokach, J., & FitzGerald, G. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13381 · Cited by 161 · see citing works
Oxalate ions and calcium oxalate crystals stimulate MCP-1 expression by renal epithelial cells
Umekawa, T., Chegini, N., & Khan, S. R. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00106.x · Cited by 135 · see citing works
Aspects on Estimation of the Risk of Calcium Oxalate Crystallization in Urine
Tiselius, H.-G. (2010) · Urologia Internationalis · doi:10.1159/000282232 · Cited by 115 · see citing works
Hesse, A., Schneeberger, W., Engfeld, S., von Unruh, G., & Sauerbruch, T. (1999) · PubMed · Cited by 97 · see citing works
Mechanisms Mediating Oxalate-Induced Alterations in Renal Cell Functions
Jonassen, J. A., Cao, L.-C., Honeyman, T. W., & Scheid, C. R. (2003) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.v13.i1.50 · Cited by 88 · see citing works
The Renal Clearance of Oxalate in Normal Subjects and Patients with Primary Hyperoxaluria
Williams, H. E., Johnson, G. A., & Smith, L. H. (1971) · Clinical Science · doi:10.1042/cs0410213 · Cited by 73 · see citing works
Chai, W., & Liebman, M. (2004) · The Journal of Urology · doi:10.1097/01.ju.0000135918.00761.8a · Cited by 71 · see citing works
Selective Elevation of Urinary Enzyme Levels after Extracorporeal Shock Wave Lithotripsy
Assimos, D. G., Boyce, W. H., Furr, E. G., et al. (1989) · The Journal of Urology · doi:10.1016/s0022-5347(17)38853-5 · Cited by 69 · see citing works
Self-citationRelationship of protein intake to urinary oxalate and glycolate excretion
Holmes, R. P., Goodman, H. O., Hart, L. J., & Assimos, D. G. (1993) · Kidney International · doi:10.1038/ki.1993.253 · Cited by 62 · see citing works
Self-citationRenal Elimination Kinetics and Plasma Half-Life of Oxalate in Man
Oßwald, H., & Hautmann, R. E. (2010) · Urologia Internationalis · doi:10.1159/000280294 · Cited by 54 · see citing works
Plasma and urinary oxalate and glycolate in healthy subjects
Hagen, L. E., Walker, V., & Sutton, R. A. L. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.1.134 · Cited by 51 · see citing works
Erythrocyte transmembrane flux and renal clearance of oxalate in idiopathic calcium nephrolithiasis
Gambaro, G., Petrarulo, M., Nardelotto, A., et al. (1995) · Kidney International · doi:10.1038/ki.1995.445 · Cited by 33 · see citing works
Schwille, P. O., Manoharan, M., Rümenapf, G., et al. (1989) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1989.27.2.87 · Cited by 31 · see citing works
Balcke, P., Zazgornik, J., Sunder–Plassmann, G., et al. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000185238 · Cited by 26 · see citing works
Increase in Calciuria and Oxaluria After a Single Chocolate Bar Load
Nguyen, N. U., Henriet, M. T., Dumoulin, G., et al. (1994) · Hormone and Metabolic Research · doi:10.1055/s-2007-1001712 · Cited by 26 · see citing works
Kasidas, G. P., Nemat, S., & Rose, G. A. (1990) · Clinica Chimica Acta · doi:10.1016/0009-8981(90)90059-2 · Cited by 18 · see citing works
Winter, P. J. V., Ganter, K., Heimbach, D., et al. (1996) · Scandinavian Journal of Urology and Nephrology · doi:10.3109/00365599609182320 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Determinants of 24-hour Urinary Oxalate Excretion
Taylor, E. N., & Curhan, G. C. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01410308 · Cited by 173 · see citing works
Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt
Weljie, A. M., Meerlo, P., Goel, N., Sengupta, A., Kayser, M. S., Abel, T., Birnbaum, M. J., Dinges, D. F., & Sehgal, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417432112 · Cited by 158 · see citing works
- Authors
- HOLMES, R. P., AMBROSIUS, W. T., & ASSIMOS, D. G.
- Affiliations
- Wake Forest University Health Sciences (US)
- Venue
- Journal of Urology
- Published
- 2005-09
- Volume
- 174
- Issue
- 3
- Pages
- 943-947
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W2028294619
- Cited by
- 93
- References
- 20
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK062284)
- National Center for Research Resources (M01RR007122)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Kidney Stones and Urolithiasis Treatments
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Nephrotoxicity and Medicinal Plants
- Keywords
- dietary oxalate, urinary oxalate excretion, plasma oxalate, calcium oxalate stones, renal tubular secretion, renal filtration, kidney injury, oxidative stress, isoprostanes
- MeSH terms
- Adult, Creatinine, Female, Glomerular Filtration Rate, Humans, Kidney Calculi, Kidney Function Tests, Kidney Tubules, Proximal, Male, Oxalates, Reference Values, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
