CoChat
Sign Up
Cited by 144Cardiac Ischemia and ReperfusionMitochondrial Function and PathologyNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.

Potent mitochondria-targeted peptides reduce myocardial infarction in rats

Cho, Janghyun, Won, Kyungheon, Wu, DunLi, Soong, Yi, Liu, Shaoyi, Szeto, Hazel H., Hong, Mun K.·2007·Coronary Artery Disease
DOI 10.1097/01.mca.0000236285.71683.b6
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Previously, we demonstrated that a novel opiate peptide, 2',6'-dimethyl-tyrosine-D-Arg-Phe-Lys-NH2, provided cardioprotection against myocardial stunning in vivo. We subsequently showed that this peptide targeted mitochondria and can scavenge reactive oxygen species. The objective of this study was to determine the role of opioid versus antioxidant activity in cardioprotection. METHODS: We compared two mitochondria-targeted peptide analogs that lacked opioid activity: SS-31 (D-Arg-2',6'-dimethyl-tyrosine-Lys-Phe-NH2) and SS-20 (Phe-D-Arg-Phe-Lys-NH2). They differ in that only SS-31 has scavenging ability. Rats (n=8/group) were randomized to SS-31, SS-20 or placebo. The drugs (3 mg/kg) or saline was administered intraperitoneally 30 min before ligation of the left anterior descending artery for 60 min, and another dose given intraperitoneally 5 min before reperfusion for 60 min. Study endpoints included myocardial infarct size, cardiac arrhythmia and myocardial lipid peroxidation. RESULTS: The area at risk was similar among the groups. The infarct area/area at risk, however, was significantly smaller in the treatment groups (53.9+/-1.1% in SS-31 group, 47.1+/-1.4% in SS-20 group, versus 59.9+/-1% in the controls, P<0.01). Lipid peroxidation was significantly reduced by both SS-31 and SS-20 treatment. Arrhythmia occurred only during the early period of coronary occlusion and was less frequent and less severe in the peptide treatment groups than in the controls (Lambeth score 5 points, 3 points, versus 13 points in the controls, P<0.05). CONCLUSIONS: This study shows that pretreatment with both SS-31 and SS-20 significantly reduced myocardial lipid peroxidation and infarct size in ischemia-reperfusion injury, and suggests that the cardioprotective properties of 2',6'-dimethyl-tyrosine-D-Arg-Phe-Lys-NH2 was primarily mediated by its antioxidant properties. As SS-20 does not scavenge reactive oxygen species, it most likely reduces reactive oxygen species production during ischemia-reperfusion.

Overview

Integrity signals

Registry

Crossref · 10.1097/01.mca.0000236285.71683.b6

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

1 of the 18 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

See all 144

Related

See all

Metadata

Authors
Cho, J., Won, K., Wu, D., Soong, Y., Liu, S., Szeto, H. H., & Hong, M. K.
Affiliations
  • Cornell University (US)
  • Weill Cornell Medicine (US)
  • St. Luke's-Roosevelt Hospital Center (US)
Corresponding author
  • Cho, Janghyun
  • Szeto, Hazel H.
  • Hong, Mun K.
ORCID
Venue
Coronary Artery Disease
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-05
Volume
18
Issue
3
Pages
215-220
ISSN
0954-6928 (ISSN-L)
DOI
10.1097/01.mca.0000236285.71683.b6
OpenAlex
W2003139013
Cited by
144
References
18
Citations by year
2026: 5 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 12 · 2019: 9 · 2018: 7 · 2017: 11 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 15 · 2012: 14
FWCI
3.07
Type
journal article
Language
en
Open access
closed
Locations
  • Coronary Artery Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (P01 DA 08924, P01DA008924)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords
SS-31, mitochondria-targeted peptide, myocardial infarction, cardioprotection, ischemia-reperfusion injury, reactive oxygen species scavenging, lipid peroxidation, cardiac arrhythmias, opioid peptides, myocardial stunning
MeSH terms
Animals, Antioxidants, Male, Mitochondria, Myocardial Infarction, Oligopeptides, Lipid Peroxidation, Myocardial Reperfusion, Rats, Sprague-Dawley, Reactive Oxygen Species, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review