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The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

Birk, Alexander V., Liu, Shaoyi, Soong, Yi, Mills, William, Singh, Pradeep, Warren, J. David, Seshan, Surya V., Pardee, Joel D., Szeto, Hazel H.·2013·Journal of the American Society of Nephrology
DOI 10.1681/asn.2012121216
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  • Compounds currently in clinical trials for mitochondrial disease are predominantly antioxidants (such as Idebenone, EPI-743 and RPI-103) and small molecules that stabilize organelle membrane architecture (Elampritide/SS31).

    “Compounds currently in clinical trials are predominantly antioxidants (such as Idebenone, EPI-743 and RPI-103) and small molecules that have the capability of stabilizing the organelle membrane architecture (Elampritide/SS31) [178].”

    From The Mitochondrial Genome in Aging and Disease and the Future of Mitochondrial Therapeutics (2022) · cites this paper as [178]

    The Discussion (page not provided) reports that SS-31 preserved mitochondrial cristae membranes and prevented swelling in rats with renal ischemia, supporting the membrane-stabilization part of the claim. Our copy does not support the broader assertion that clinical-trial compounds are predominantly antioxidants, identify Idebenone, EPI-743 or RPI-103 as trial compounds, or establish trials for mitochondrial disease. (LLM, conf=0.86)

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Research works printed but not linked: 51

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Metadata

Authors
Birk, A. V., Liu, S., Soong, Y., Mills, W., Singh, P., Warren, J. D., Seshan, S. V., Pardee, J. D., & Szeto, H. H.
Venue
Journal of the American Society of Nephrology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-08
Volume
24
Issue
8
Pages
1250-1261
ISSN
1046-6673
DOI
10.1681/asn.2012121216
Cited by
479
References
10
Language
en

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