The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Torsade de Pointes Due to Noncardiac Drugs: Most Patients Have Easily Identifiable Risk Factors
Abstract
Numerous medications, including drugs prescribed for noncardiac indications, can lead to QT prolongation and trigger torsade de pointes. Although this complication occurs only rarely, it may have lethal consequences. It is therefore important to know if patients with torsade de pointes associated with noncardiac drugs have risk factors that are easy to identify. We reviewed reports of drug-induced torsade de pointes and analyzed each case of torsade de pointes associated with a noncardiac drug for the presence of risk factors for the long QT syndrome that can be easily identified from the medical history or clinical evaluation (female gender, heart disease, electrolyte disturbances, excessive dosing, drug interactions, and history of familial long QT syndrome). We identified 249 patients with torsade de pointes caused by noncardiac drugs. The most commonly identified risk factor was female gender (71%). Other risk factors were frequently present (18%-41%). Virtually all patients had at least 1 of these risk factors, and 71% of patients had 2 or more risk factors. Our study suggests that almost all patients with torsade de pointes secondary to noncardiac drugs have risk factors that can be easily identified from the medical history before the initiation of therapy with the culprit drug.
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Cites
MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia
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Female Gender as a Risk Factor for Torsades de Pointes Associated With Cardiovascular Drugs
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Self-citationTaking the “Idio” out of “Idiosyncratic”: Predicting Torsades de Pointes
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Torsades de Pointes Occurring in Association With Terfenadine Use
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Mechanism of the Cardiotoxic Actions of Terfenadine
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The Spectrum of Symptoms and QT Intervals in Carriers of the Gene for the Long-QT Syndrome
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Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036
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Metadata
- Authors
- Zeltser, D., Justo, D., Halkin, A., Prokhorov, V., Heller, K., & Viskin, S.
- Venue
- Medicine
- Published
- 2003-07
- Volume
- 82
- Issue
- 4
- Pages
- 282-290
- ISSN
- 0025-7974 (ISSN-L)
- OpenAlex
- W2066538341
- Cited by
- 273
- References
- 101
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Torsade de Pointes Due to Noncardiac Drugs: Most Patients Have Easily Identifiable Risk Factors. https://app.cochat.ai/papers/10.1097/01.md.0000085057.63483.9b
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- Zeltser, D., Justo, D., Halkin, A., Prokhorov, V., Heller, K., & Viskin, S. (2003). Torsade de Pointes Due to Noncardiac Drugs: Most Patients Have Easily Identifiable Risk Factors. Medicine. https://doi.org/10.1097/01.md.0000085057.63483.9b
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
