The DOI matches its Crossref record; 201 of the 201 references it cites were found in a registry or an index.
Recent understanding of IBD pathogenesis: Implications for future therapies
Abstract
The inflammatory bowel diseases (IBD) are comprised of two major phenotypes, Crohn's disease (CD) and ulcerative colitis (UC). Research over the last couple of years has led to great advances in understanding the inflammatory bowel diseases and their underlying pathophysiologic mechanisms. From the current understanding, it is likely that chronic inflammation in IBD is due to aggressive cellular immune responses to a subset of luminal bacteria. Susceptibility to disease is thereby determined by genes encoding immune responses which are triggered by environmental stimuli. Based on extensive research over the last decade, there are several new and novel pathways and specific targets on which to focus new therapeutics. The following review summarizes the current view on the four basic tenets of the pathophysiological basis of IBD and its implications for therapies of IBD: genetics, immune dysregulation, barrier dysfunction and the role of the microbial flora.
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Citations
Cites
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Cited by
Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications
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Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management
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Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation
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Unstable Composition of the Fecal Microbiota in Ulcerative Colitis During Clinical Remission
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Metadata
- Authors
- Kucharzik, T., Maaser, C., Lügering, A., Kagnoff, M., Mayer, L., Targan, S., & Domschke, W.
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11
- Volume
- 12
- Issue
- 11
- Pages
- 1068-1083
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2075035567
- Cited by
- 254
- References
- 201
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kucharzik, T., Maaser, C., Lügering, A., Kagnoff, M., Mayer, L., Targan, S., & Domschke, W. (2006). Recent understanding of IBD pathogenesis: Implications for future therapies. Inflammatory Bowel Diseases. https://doi.org/10.1097/01.mib.0000235827.21778.d5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
