Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications

A metagenome-wide association study of gut microbiota in type 2 diabetes

Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

Cross-talk between <i>Akkermansia muciniphila</i> and intestinal epithelium controls diet-induced obesity

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works

The impact of the gut microbiota on human health: an integrative view

Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710 · see citing works

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

Farquhar, M. G., & Palade, G. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.375 · Cited by 3,637 · see citing works

Genetics and pathogenesis of inflammatory bowel disease

Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,630 · see citing works

Occludin: a novel integral membrane protein localizing at tight junctions.

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580 · see citing works

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works

Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130 · see citing works

<i>Akkermansia muciniphila</i> and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308778 · Cited by 1,931 · see citing works

Intestinal homeostasis and its breakdown in inflammatory bowel disease

Maloy, K., & Powrie, F. (2011) · Nature · doi:10.1038/nature10208 · Cited by 1,865 · see citing works

Intestinal barrier function: molecular regulation and disease pathogenesis

Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775 · see citing works

An increase in the <i>Akkermansia</i> spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

Shin, N.-R., Lee, J.-C., Lee, H.-Y., Kim, M.-S., Whon, T. W., Lee, M.-S., & Bae, J.-W. (2014) · Gut · doi:10.1136/gutjnl-2012-303839 · Cited by 1,550 · see citing works

Claudins and the Modulation of Tight Junction Permeability

Günzel, D., & Yu, A. S. L. (2013) · Physiological Reviews · doi:10.1152/physrev.00019.2012 · Cited by 1,456 · see citing works

Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress

Kim, Y. S., & Ho, S. B. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0131-2 · Cited by 1,437 · see citing works

Regulation of intestinal epithelial permeability by tight junctions

Suzuki, T. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1070-x · Cited by 1,365 · see citing works

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

Zeißig, S., Bürgel, N., Günzel, D., Richter, J. F., Mankertz, J., Wahnschaffe, U., Kroesen, A. J., Zeitz, M., Fromm, M., & Schulzke, J. (2006) · Gut · doi:10.1136/gut.2006.094375 · Cited by 1,218 · see citing works

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

Saitou, M., Furuse, M., Sasaki, H., Schulzke, J.-D., Fromm, M., Takano, H., Noda, T., & Tsukita, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4131 · Cited by 1,195 · see citing works

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1351 · Cited by 1,151 · see citing works

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136 · see citing works

Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities

Hanauer, S. B. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000195385.19268.68 · Cited by 969 · see citing works

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

Balda, M. S., Whitney, J. A., Flores, C., González, S., Cereijido, M., & Matter, K. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.1031 · Cited by 876 · see citing works

Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity

Cani, P. D., Osto, M., Geurts, L., & Everard, A. (2012) · Gut Microbes · doi:10.4161/gmic.19625 · Cited by 864 · see citing works

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

Guinane, C. M., & Cotter, P. D. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13482996 · Cited by 846 · see citing works

New developments in goblet cell mucus secretion and function

Birchenough, G. M. H., Johansson, M., Gustafsson, J. K., Bergström, J. H., & Hansson, G. C. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.32 · Cited by 820 · see citing works

Cytokine regulation of tight junctions

Capaldo, C., & Nusrat, A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.08.027 · Cited by 724 · see citing works

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

Guo, S., Al–Sadi, R., Said, H. M., & Ma, T. Y. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.10.014 · Cited by 722 · see citing works

Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells

Furuse, M., Furuse, K., Sasaki, H., & Tsukita, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.263 · Cited by 712 · see citing works

Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression

Wang, F., Graham, W. V., Wang, Y., Witkowski, E. D., Schwarz, B. T., & Turner, J. R. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62264-x · Cited by 692 · see citing works

Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia

Moreira, A. P. B., Teixeira, T. F. S., Machado, A. B. F., Pelúzio, M. D. C. G., & Alfenas, R. D. C. G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001213 · Cited by 654 · see citing works

Epithelial Barriers in Homeostasis and Disease

Marchiando, A. M., Graham, W. V., & Turner, J. R. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092135 · Cited by 612 · see citing works

Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation

Berkes, J., Viswanathan, V. K., Savkovic, S. D., & Hecht, G. (2003) · Gut · doi:10.1136/gut.52.3.439 · Cited by 594 · see citing works

Occludin and claudins in tight-junction strands: leading or supporting players?

Tsukita, S., & Furuse, M. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01578-0 · Cited by 592 · see citing works

Regulation of tight junctions and loss of barrier function in pathophysiology

Harhaj, N. S., & Antonetti, D. A. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.08.007 · Cited by 543 · see citing works

Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis

Kang, C.-S., Ban, M., Choi, E.-J., Moon, H.-G., Jeon, J.-S., Kim, D.-K., Park, S.-K., Jeon, S. G., Roh, T.-Y., Myung, S.-J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076520 · Cited by 543 · see citing works

JAM-A regulates permeability and inflammation in the intestine in vivo

Laukoetter, M. G., Nava, P., Lee, W. Y., Severson, E. A., Capaldo, C., Babbin, B. A., Williams, I. R., Koval, M. H., Peatman, E., Campbell, J. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071416 · Cited by 512 · see citing works

Occludin: Structure, function and regulation

FELDMAN, G., Mullin, J. M., & RYAN, M. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.01.009 · Cited by 485 · see citing works

Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis

Mennigen, R. B., Nolte, K., Rijcken, E. J. M., Utech, M., Loeffler, B., Senninger, N. J., & Bruewer, M. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90534.2008 · Cited by 484 · see citing works

Welcome to the neighborhood: epithelial cell‐derived cytokines license innate and adaptive immune responses at mucosal sites

Saenz, S. A., Taylor, B. C., & Artis, D. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00713.x · Cited by 484 · see citing works

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

Marchiando, A. M., Shen, L., Graham, W. V., Weber, C. R., Schwarz, B. T., Austin, J. R., Raleigh, D. R., Guan, Y., Watson, A. J. M., Montrose, M. H., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200902153 · Cited by 475 · see citing works

Functional biology of intestinal goblet cells

Specian, R. D., & Oliver, M. G. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.260.2.c183 · Cited by 468 · see citing works

Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure

Shen, L., Black, E. D., Witkowski, E. D., Lencer, W. I., Guerriero, V., Schneeberger, E. E., & Turner, J. R. (2006) · Journal of Cell Science · doi:10.1242/jcs.02915 · Cited by 467 · see citing works

Tyrosine phosphorylation and dissociation of occludin–ZO-1 and E-cadherin–β-catenin complexes from the cytoskeleton by oxidative stress

Rao, R., Basuroy, S., Rao, V. U., KARNAKY, K. J., & Gupta, A. K. (2002) · Biochemical Journal · doi:10.1042/bj20011804 · Cited by 402 · see citing works

Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier.

Ye, D., Ma, I., & Ma, T. (2006) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00318.2005 · Cited by 395 · see citing works

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

Su, L., Nalle, S. C., Shen, L., Turner, E. S., Singh, G., Breskin, L. A., Khramtsova, E. A., Khramtsova, G. F., Tsai, P., Fu, Y., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.011 · Cited by 393 · see citing works

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease

Zolotarevsky, Y., Hecht, G. A., Koutsouris, A., Gonzalez, D. E., Quan, C., Tom, J., Mrsny, R. J., & Turner, J. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.34235 · Cited by 385 · see citing works

CURRENT CONCEPTS OF THE ETIOLOGY AND PATHOGENESIS OF ULCERATIVE COLITIS AND CROHN’S DISEASE

Sartor, R. B. (1995) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(21)00207-7 · Cited by 384 · see citing works

Interferon‐γ induces internalization of epithelial tight junction proteins via a macropinocytosis‐like process

Bruewer, M., Utech, M., Ivanov, A. I., Hopkins, A. M., Parkos, C. A., & Nusrat, A. (2005) · The FASEB Journal · doi:10.1096/fj.04-3260com · Cited by 364 · see citing works

Mechanism of IFN-γ-induced Endocytosis of Tight Junction Proteins: Myosin II-dependent Vacuolarization of the Apical Plasma Membrane

Utech, M., Ivanov, A. I., Samarin, S., Bruewer, M., Turner, J. R., Mrsny, R. J., Parkos, C. A., & Nusrat, A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-03-0193 · Cited by 347 · see citing works

The intestinal epithelial barrier in the control of homeostasis and immunity

Rescigno, M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.003 · Cited by 346 · see citing works

Myosin light chain kinase: pulling the strings of epithelial tight junction function

Cunningham, K. E., & Turner, J. R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06526.x · Cited by 345 · see citing works

Epithelial Cell Shedding and Barrier Function

Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J., & Pritchard, D. M. (2014) · Veterinary Pathology · doi:10.1177/0300985814559404 · Cited by 332 · see citing works

Gastrointestinal stem cells

Brittan, M., & Wright, N. A. (2002) · The Journal of Pathology · doi:10.1002/path.1155 · Cited by 330 · see citing works

Epithelial transport and barrier function in occludin-deficient mice

Schulzke, J., Gitter, A. H., Mankertz, J., Spiegel, S., Seidler, U. E., Amasheh, S., Saitou, M., Tsukita, S., & Fromm, M. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.01.008 · Cited by 320 · see citing works

Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated.

Tsukita, S., Oishi, K., Akiyama, T. H., Yamanashi, Y., Yamamoto, T. S., & Tsukita, S. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.4.867 · Cited by 308 · see citing works

COOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos

Chen, Y., Merzdorf, C., Paul, D. L., & Goodenough, D. A. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.891 · Cited by 302 · see citing works

Phosphorylation of occludin correlates with occludin localization and function at the tight junction

Wong, V. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.6.c1859 · Cited by 288 · see citing works

The epidemiology and the pathogenesis of inflammatory bowel disease

Karlinger, K., Györke, T., Makó, E., Mester, Á. R., & Tarján, Z. (2000) · European Journal of Radiology · doi:10.1016/s0720-048x(00)00238-2 · Cited by 287 · see citing works

Inflammatory Bowel Disease Characteristics Among African Americans, Hispanics, and Non-Hispanic Whites: Characterization of a Large North American Cohort

Nguyen, G. C., Torres, E. A., Regueiro, M. D., Bromfield, G. P., Bitton, A., Stempak, J. M., Dassopoulos, T., Schumm, L. P., Gregory, F. J., Griffiths, A. M., et al. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00504.x · Cited by 285 · see citing works

Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells.

Ozaki, H., Ishii, K., Horiuchi, H., Arai, H., Kawamoto, T., Okawa, K., Iwamatsu, A., & Kita, T. (1999) · PubMed · Cited by 270 · see citing works

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex

Nunbhakdi‐Craig, V., Machleidt, T., Ogris, E., Bellotto, D. J., White, C. L., & Sontag, E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200206114 · Cited by 266 · see citing works

AMP-activated protein kinase regulates the assembly of epithelial tight junctions

Zhang, L., Li, J., Young, L. H., & Caplan, M. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608531103 · Cited by 258 · see citing works

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function

Yu, D., Marchiando, A. M., Weber, C. R., Raleigh, D. R., Wang, Y., Shen, L., & Turner, J. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908869107 · Cited by 256 · see citing works

Recent understanding of IBD pathogenesis: Implications for future therapies

Kucharzik, T. F., Maaser, C., Lügering, A., Kagnoff, M. F., Mayer, L., Targan, S. R., & Domschke, W. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000235827.21778.d5 · Cited by 254 · see citing works

Twenty-first Bowditch lecture. The epithelial junction: bridge, gate, and fence.

Jm, D. (1977) · PubMed · Cited by 252 · see citing works

Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect

Monsuur, A. J., de Bakker, P. I. W., Alizadeh, B. Z., Zhernakova, A., Bevova, M. R., Strengman, E., Franke, L., Slot, R. V. ‘., van Belzen, M. J., Lavrijsen, I. C. M., et al. (2005) · Nature Genetics · doi:10.1038/ng1680 · Cited by 243 · see citing works

Cutting Edge: Combined Treatment of TNF-α and IFN-γ Causes Redistribution of Junctional Adhesion Molecule in Human Endothelial Cells

Ozaki, H., Ishii, K., Horiuchi, H., Arai, H., Kawamoto, T., Okawa, K., Iwamatsu, A., & Kita, T. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.553 · Cited by 235 · see citing works

Intestinal microbiota in health and disease

Kåhrström, C. T., Pariente, N., & Weiss, U. K. (2016) · Nature · doi:10.1038/535047a · Cited by 231 · see citing works

Occludin Phosphorylation in Regulation of Epithelial Tight Junctions

Rao, R. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04054.x · Cited by 230 · see citing works

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells

Zahraoui, A., Joberty, G., Arpin, M., Fontaine, J., Hellio, R., Tavitian, A., & Louvard, D. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.1.101 · Cited by 228 · see citing works

Regulation and roles for claudin‐family tight junction proteins

Findley, M. K., & Koval, M. H. (2009) · IUBMB Life · doi:10.1002/iub.175 · Cited by 224 · see citing works

Intestinal Permeability Test As A Predictor of Clinical Course in Crohn's Disease

Renata D'Incà, Leo, V. D., Corrao, G., Martines, D., D’Odorico, A., Mestriner, C., Venturi, C., Longo, G., & Sturniolo, G. C. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01444.x · Cited by 218 · see citing works

Tight junctions on the move: molecular mechanisms for epithelial barrier regulation

Shen, L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06613.x · Cited by 213 · see citing works

Different intestinal permeability patterns in relatives and spouses of patients with Crohn’s disease: an inherited defect in mucosal defence?

Söderholm, J. D., Olaison, G., Lindberg, E., Hannestad, U., Vindels, A., Tysk, C., Järnerot, G., & Sjödahl, R. I. (1999) · Gut · doi:10.1136/gut.44.1.96 · Cited by 206 · see citing works

Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3

Kale, G., Naren, A. P., Sheth, P., & Rao, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00167-0 · Cited by 196 · see citing works

Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction

Damms-Machado, A., Louis, S., Schnitzer, A., Volynets, V., Rings, A., Basrai, M., & Bischoff, S. C. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.131110 · Cited by 195 · see citing works

Protein Phosphatases 2A and 1 Interact with Occludin and Negatively Regulate the Assembly of Tight Junctions in the CACO-2 Cell Monolayer

Seth, A., Sheth, P., Elias, B. C., & Rao, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610597200 · Cited by 191 · see citing works

Increased Proteasome-Mediated Degradation of Occludin in Irritable Bowel Syndrome

Coëffier, M., Gloro, R., Boukhettala, N., Aziz, M., Lecleire, S., Vandaele, N., Antonietti, M., Savoye, G., Bôle-Feysot, C., Déchelotte, P., et al. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.700 · Cited by 185 · see citing works

Abnormal Intestinal Permeability Predicts Relapse in Inactive Crohn Disease

Arnott, K. K. I. D. R. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200750056637 · Cited by 184 · see citing works

Expression of Kinase-inactive c-Src Delays Oxidative Stress-induced Disassembly and Accelerates Calcium-mediated Reassembly of Tight Junctions in the Caco-2 Cell Monolayer

Basuroy, S., Sheth, P., Kuppuswamy, D., Balasubramanian, S., Ray, R. M., & Rao, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211710200 · Cited by 181 · see citing works

Intestinal Epithelial Barrier Dysfunction in Disease and Possible Therapeutical Interventions

Catalioto, R.-M., Maggi, C. A., & Giuliani, S. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711794839179 · Cited by 169 · see citing works

Redistribution and Phosphorylation of Occludin During Opening and Resealing of Tight Junctions in Cultured Epithelial Cells

Farshori, P. (1999) · The Journal of Membrane Biology · doi:10.1007/s002329900544 · Cited by 167 · see citing works

Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitisAn unusual case of ascites

Wapenaar, M. C., Monsuur, A. J., Bodegraven, A. A. V., Weersma, R., Bevova, M. R., Linskens, R. K., Howdle, P. D., Holmes, G. K. T., Mulder, C. J. J., Dijkstra, G. D. H., et al. (2007) · Gut · doi:10.1136/gut.2007.133132 · Cited by 163 · see citing works

Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis

Ahmad, R., Chaturvedi, R., Olivares–Villagómez, D., Habib, T., Asim, M., Punit, S., Polk, D. B., Wilson, K. T., Washington, M. K., Kaer, L. V., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.21 · Cited by 162 · see citing works

The Life and Death of Epithelia During Inflammation: Lessons Learned from the Gut

Koch, S., & Nusrat, A. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-120905 · Cited by 153 · see citing works

Tumor Necrosis Factor-induced Long Myosin Light Chain Kinase Transcription Is Regulated by Differentiation-dependent Signaling Events

Graham, W. V., Wang, F., Clayburgh, D. R., Cheng, J. X., Yoon, B., Wang, Y., Lin, A., & Turner, J. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602164200 · Cited by 146 · see citing works

Gastrointestinal Stem Cells. II. Intestinal stem cells

Bjerknes, M., & Cheng, H. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00160.2005 · Cited by 139 · see citing works

Increased intestinal permeability as a risk factor for type 2 diabetes

Cox, A. J., Zhang, P., Bowden, D. W., Devereaux, B., Davoren, P. M., Cripps, A. W., & West, N. P. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.09.004 · Cited by 138 · see citing works

Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis

Nighot, P. K., Al–Sadi, R., Rawat, M., Guo, S., Watterson, D. M., & Ma, T. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00256.2015 · Cited by 132 · see citing works

Compromised Intestinal Epithelial Barrier Induces Adaptive Immune Compensation that Protects from Colitis

Khounlotham, M., Kim, W., Peatman, E., Nava, P., Contreras, O. M., Addis, C. R., Koch, S., Fournier, B., Nusrat, A., Denning, T. L., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.017 · Cited by 129 · see citing works

A Key Claudin Extracellular Loop Domain is Critical for Epithelial Barrier Integrity

Mrsny, R. J., Brown, G. T., Gerner-Smidt, K., Buret, A. G., Meddings, J. B., Quan, C. L., Koval, M. H., & Nusrat, A. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070698 · Cited by 124 · see citing works

Alterations of the mucosal immune system in inflammatory bowel disease

MacDermoit, R. P. (1996) · Journal of Gastroenterology · doi:10.1007/bf02358624 · Cited by 123 · see citing works

Genetic Variation in Myosin IXB Is Associated With Ulcerative Colitis

Bodegraven, A. A. V., Curley, C., Hunt, K. A., Monsuur, A. J., Linskens, R. K., Onnie, C. M., Crusius, J. B. A., Annese, V., Latiano, A., Silverberg, M. S., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.09.011 · Cited by 119 · see citing works

AMP-activated Protein Kinase Mediates the Interferon-γ-induced Decrease in Intestinal Epithelial Barrier Function

Scharl, M. M., Paul, G., Barrett, K. E., & McCole, D. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046292 · Cited by 110 · see citing works

The Tight Junction Protein ZO-2 Contains Three PDZ (PSD-95Discs-LargeZO-1) Domains and an Alternatively Spliced Region

Beatch, M. D., Jesaitis, L. A., Gallin, W. J., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.25723 · Cited by 103 · see citing works

Intestinal Epithelial Barrier Dysfunction in Crohn's Disease

Y, T. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-214-44099 · Cited by 100 · see citing works

New Diseases Derived or Associated with the Tight Junction

Cereijido, M., Contreras, R. G., Flores-Benítez, D., Flores-Maldonado, C., Larré, I., Ruiz, A., & Shoshani, L. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.02.003 · Cited by 100 · see citing works

Overcoming barriers in the study of tight junction functions: from occludin to claudin

Tsukita, S., & Furuse, M. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00212.x · Cited by 99 · see citing works

The intestinal epithelium is an integral component of a communications network

Kagnoff, M. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75225 · Cited by 99 · see citing works

Molecular and clinical basis for the regeneration of human gastrointestinal epithelia

Okamoto, R., & Watanabe, M. (2004) · Journal of Gastroenterology · doi:10.1007/s00535-003-1259-8 · Cited by 98 · see citing works

Expression of Zonula Occludens and Adherens Junctional Proteins in Human Venous and Arterial Endothelial Cells: Role of Occludin in Endothelial Solute Barriers

Kevil, C. G., Okayama, N., Trocha, S. D., Kalogeris, T. J., Coe, L. L., Specian, R. D., DAVIS, C. P., & Alexander, J. S. (1998) · Microcirculation · doi:10.1038/sj.mn.7300011 · Cited by 97 · see citing works

Intestinal Epithelial Cell Regulation of Mucosal Inflammation

Yu, Y., Sitaraman, S. V., & Gewirtz, A. T. (2004) · Immunologic Research · doi:10.1385/ir:29:1-3:055 · Cited by 82 · see citing works

Expression of Zonula Occludens and Adherens Junctional Proteins in Human Venous and Arterial Endothelian Cells: Role of Occludin in Endothelial Solute Barriers

Kevil, C. G., Okayama, N., Trocha, S. D., et al. (1998) · Microcirculation · doi:10.1111/j.1549-8719.1998.tb00069.x · Cited by 79 · see citing works

Structure and function of the intestinal epithelial barrier in health and disease.

Madara, J. L., Nash, S. V., Moore, R., & Atisook, K. (1990) · PubMed · Cited by 75 · see citing works

Etiology and pathogenesis of inflammatory bowel disease.

Schmidt, C., & Stallmach, A. (2005) · PubMed · Cited by 55 · see citing works

Somatostatin regulates tight junction proteins expression in colitis mice.

Li, X., Wang, Q., Xu, H. J., Tao, L., Lu, J., Cai, L., & Wang, C. (2014) · PubMed Central · Cited by 48 · see citing works

Regulation of Intestinal Epithelial Cell Apoptosis and the Pathogenesis of Inflammatory Bowel Disorders

Ruemmele, F. M., Seidman, E. G., & Lentze, M. J. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200203000-00005 · Cited by 48 · see citing works

Understanding epithelial homeostasis in the intestine

Mey, J. D., & Freund, J. (2013) · Tissue Barriers · doi:10.4161/tisb.24965 · Cited by 46 · see citing works

Gut permeability, obesity, and metabolic disorders: who is the chicken and who is the egg

Fasano, A. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.148338 · Cited by 45 · see citing works

Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin

Chelakkot, C., Ghim, J., Rajasekaran, N., Choi, J., Kim, J.-H., Jang, M. H., Shin, Y. K., Suh, P., & Ryu, S. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-01797-y · Cited by 43 · see citing works

New Insights into Inflammatory Bowel Disease Pathophysiology: Paving the Way for Novel Therapeutic Targets

Stefanelli, T., Malesci, A., Repici, A., et al. (2008) · Current Drug Targets · doi:10.2174/138945008784221170 · Cited by 42 · see citing works

Messages from the Inside. The Dynamic Environment that Favors Intestinal Homeostasis

Eri, R. D., & Chieppa, M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00323 · Cited by 36 · see citing works

Nedd4–2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia

Raikwar, N. S., Vandewalle, A., & Thomas, C. P. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00674.2009 · Cited by 36 · see citing works

Genetic Aspects of Intestinal Permeability in Inflammatory Bowel Disease

Takeuchi, K., Maiden, L., & Bjarnason, I. (2004) · Novartis Foundation symposium · doi:10.1002/0470090480.ch11 · Cited by 25 · see citing works

Transforming JB6 cells exhibit enhanced integrin-mediated adhesion to osteopontin

Chang, P., & Chambers, A. F. (2000) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(20000701)78:1 · Cited by 19 · see citing works

Is GDF15 a Novel Biomarker to Predict the Development of Prediabetes or Diabetes?

Hur, K. Y. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.6.437 · Cited by 9 · see citing works

Treatment for acute severe ulcerative colitis

Leake, I. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.112 · Cited by 5 · see citing works

Novel therapeutic strategy for Wilson disease

Leake, I. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.115 · Cited by 3 · see citing works

Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Mohammad, S., & Thiemermann, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594150 · Cited by 585 · see citing works

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

The role of lipopolysaccharide-induced cell signalling in chronic inflammation

Page, M. J., Kell, D. B., & Pretorius, E. (2022) · Chronic Stress · doi:10.1177/24705470221076390 · Cited by 315 · see citing works

Exercise sustains the hallmarks of health

Qiu, Y., Fernández-García, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otín, C., & Xiao, J. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.10.003 · Cited by 270 · see citing works

Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway

Li, C., Ai, G., Wang, Y., Lu, Q., Luo, C., Tan, L., Lin, G., Liu, Y., Li, Y., Zeng, H., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104603 · Cited by 262 · see citing works

Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice

Saccon, T. D., Nagpal, R., Yadav, H., Cavalcante, M. B., Nunes, A. D. D. C., Schneider, A., Gesing, A., Hughes, B., Yousefzadeh, M., Tchkonia, T., et al. (2021) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glab002 · Cited by 247 · see citing works

Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)

Benedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242 · see citing works

The intestinal barrier in disorders of the central nervous system

Pellegrini, C., Fornai, M., D'Antongiovanni, V., Antonioli, L., Bernardini, N., & Derkinderen, P. (2023) · The Lancet Gastroenterology &amp; Hepatology · doi:10.1016/s2468-1253(22)00241-2 · Cited by 239 · see citing works

Tryptophan metabolites along the microbiota-Gut-Brain axis: an interkingdom communication system influencing the gut in health and disease

Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920928984 · Cited by 221 · see citing works

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works

You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan

Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200 · see citing works

The role of gut microbiota in bone homeostasis

Behera, J., Ison, J., Tyagi, S. C., & Tyagi, N. (2020) · Bone · doi:10.1016/j.bone.2020.115317 · Cited by 162 · see citing works

Gut Microbiome in Psoriasis: An Updated Review

Sikora, M., Stec, A., Chrabaszcz, M., Knot, A., Waskiel-Burnat, A., Rakowska, A., Olszewska, M., & Rudnicka, L. (2020) · Pathogens · doi:10.3390/pathogens9060463 · Cited by 118 · see citing works

MicroRNA and Gut Microbiota: Tiny but Mighty—Novel Insights into Their Cross-talk in Inflammatory Bowel Disease Pathogenesis and Therapeutics

Casado-Bedmar, M., & Viennois, E. (2022) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjab223 · Cited by 77 · see citing works

Neuroprotective Effects of Bifidobacterium breve CCFM1067 in MPTP-Induced Mouse Models of Parkinson’s Disease

Li, T., Chu, C., Yu, L., Zhai, Q., Wang, S., Zhao, J., Zhang, H., Chen, W., & Tian, F. (2022) · Nutrients · doi:10.3390/nu14214678 · Cited by 76 · see citing works

Treatment of inflammatory bowel disease: Potential effect of NMN on intestinal barrier and gut microbiota

Huang, P., Wang, X., Wang, S., Wu, Z., Zhou, Z., Shao, G., Ren, C., Kuang, M., Zhou, Y., Jiang, A., et al. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.08.011 · Cited by 43 · see citing works

The Many Faces of Microbiota-Gut-Brain Axis in Autism Spectrum Disorder

Gonçalves, C. L., Doifode, T., Rezende, V. L., Costa, M. A., Rhoads, J. M., & Soutullo, C. A. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122357 · Cited by 42 · see citing works

Angelica oil restores the intestinal barrier function by suppressing S100A8/A9 signalling in mice with ulcerative colitis

Liu, C., He, Y.-X., Zhang, J.-N., Yang, F., Wang, S.-Y., Hu, J.-L., & Yu, Y. (2023) · Phytomedicine · doi:10.1016/j.phymed.2022.154490 · Cited by 27 · see citing works

Carotenoids Improve Obesity and Fatty Liver Disease via Gut Microbiota: A Narrative Review

Hashemi, D., Fard, M. V., Mohammadhasani, K., Barati, M., & Nattagh‐Eshtivani, E. (2025) · Food Science &amp; Nutrition · doi:10.1002/fsn3.70092 · Cited by 15 · see citing works

Strain-Specific Anti-Inflammatory Effects of Faecalibacterium prausnitzii Strain KBL1027 in Koreans

Seo, B., Jeon, K., Kim, W.-K., Jang, Y. J., Cha, K. H., & Ko, G. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10213-7 · Cited by 12 · see citing works

Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium

Acharya, P., Beckel, J. M., Ruiz, W. G., Wang, E., Rojas, R., Birder, L. A., & Apodaca, G. L. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00341.2003 · Cited by 252 · see citing works

Tight Junctions Involving Occludin and Claudins

Tsukita, S. (2000) · Cornea · doi:10.1097/00003226-200011003-00002

Tight junction proteins in HCC and metastatic liver tumours

Páska, C., Orbán, E., Kiss, A., et al. (2005) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2005-869745

Perspectives on tight junction research

Schulzke, J., Günzel, D., John, L., & Fromm, M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06485.x · Cited by 54 · see citing works

Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival

Kuo, W., Odenwald, M. A., Turner, J. R., & Zuo, L. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14798 · Cited by 633 · see citing works