Liposomal Drug Delivery

Allison, S. Dean

doi:10.1097/01.nan.0000264712.26219.67

Cited by 45Nanoparticle-Based Drug DeliveryDrug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems

Liposomal Drug Delivery

Allison, S. Dean·2007·Journal of Infusion Nursing

DOI 10.1097/01.nan.0000264712.26219.67

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Abstract

In Brief Liposomes are composed of phospholipids, the basic components of human cell walls. Liposome encapsulation improves a medication's bioavailability, which can extend treatment effects and reduce drug dosing. The therapeutic advantages of liposomal drug delivery, such as the ability of long-circulating liposomes to accumulate preferentially at disease sites, including tumors and sites of inflammation, are well recognized. In cases in which a single active has more than one liposome product available, formulation changes leading to differences in pharmacokinetics, toxicity, and clinical efficacy are described. Liposomes are composed of phospholipids, the basic components of human cell walls. Liposome encapsulation improves a medication's bioavailability, which can extend treatment effects and reduce drug dosing. The therapeutic advantages of liposomal drug delivery, such as the ability of longcirculating liposomes to accumulate preferentially at disease sites, including tumors and sites of inflammation, are well recognized. In cases in which a single active has more than one liposome product available, formulation changes leading to differences in pharmacokinetics, toxicity, and clinical efficacy are described.

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Liposomes are generally biocompatible, biodegradable, nontoxic, and able to entrap lipophilic and hydrophilic drugs for site-specific drug delivery.
“They are generally biocompatible, biodegradable, nontoxic, and able to entrap lipophilic and hydrophilic drugs for site-specific drug delivery.77,78”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [77]

Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer
O’Brien, M. E. R., Wigler, N., Inbar, M., Rosso, R., Grischke, E., Santoro, A., Catane, R., Kieback, D., Tomczak, P., Ackland, S. P., et al. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh097 · Cited by 1,739 · see citing works
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.
Papahadjopoulos, D., Allen, T. M., Gabizón, A., Mayhew, E. G., Matthay, K. K., Huang, S. K., Lee, K. D., Woodle, M. C., Lasiç, D. D., & Redemann, C. T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11460 · Cited by 1,621 · see citing works
Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.
Gabizón, A., Catane, R., Uziely, B., Kaufman, B., Safra, T., Cohen, R., Martin, F., Huang, A., & Barenholz, Y. (1994) · PubMed · Cited by 1,382 · see citing works
Liposomal Amphotericin B for Empirical Therapy in Patients with Persistent Fever and Neutropenia
Walsh, T. J., Finberg, R. W., Arndt, C., Hiemenz, J., Schwartz, C., Bodensteiner, D., Pappas, P., Seibel, N., Greenberg, R. N., Dummer, S., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903113401004 · Cited by 1,205 · see citing works
Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia
Yatvin, M. B., Weinstein, J. N., Dennis, W. H., & Blumenthal, R. P. (1978) · Science · doi:10.1126/science.364652 · Cited by 959 · see citing works
Advanced strategies in liposomal cancer therapy: Problems and prospects of active and tumor specific drug release
Andresen, T. L., Jensen, S. S., & Jørgensen, K. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2004.12.001 · Cited by 580 · see citing works
Pharmacokinetics of stealth versus conventional liposomes: effect of dose
Allen, T. M., & Hansen, C. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90201-i · Cited by 579 · see citing works
A Randomized, Double-Blind Comparative Trial Evaluating the Safety of Liposomal Amphotericin B versus Amphotericin B Lipid Complex in the Empirical Treatment of Febrile Neutropenia
Wingard, J. R., White, M. H., Anaissie, E. J., Raffalli, J. T., Goodman, J., Arrieta, A. C., & L Amph/ABLC Collaborative Study Group (2000) · Clinical Infectious Diseases · doi:10.1086/317451 · Cited by 524 · see citing works
Liposome‐encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first‐line therapy of metastatic breast carcinoma
Harris, L. N., Batist, G., Belt, R. J., Rovira, D. K., Navari, R. M., Azarnia, N., Welles, L., Winer, E. P., & TLC D‐99 Study Group (2001) · Cancer · doi:10.1002/cncr.10201 · Cited by 511 · see citing works
The Liposomal Formulation of Doxorubicin
Abraham, S. A., Waterhouse, D., Mayer, L. D., Cullis, P. R., Madden, T. D., & Bally, M. B. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)91004-5 · Cited by 426 · see citing works
Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells
Mamot, C., Drummond, D. C., Greiser, U., Hong, K., Kirpotin, D. B., Marks, J. D., & Park, J. W. (2004) · The Women s Oncology Review · doi:10.3109/14733400410001727592 · Cited by 298 · see citing works
A Comparison of Liposomal Formulations of Doxorubicin with Drug Administered in Free Form
Waterhouse, D., Tardi, P. G., Mayer, L. D., & Bally, M. B. (2001) · Drug Safety · doi:10.2165/00002018-200124120-00004 · Cited by 242 · see citing works
Liposomal Doxorubicin
Tardi, P. G., Boman, N. L., & Cullis, P. R. (1996) · Journal of drug targeting · doi:10.3109/10611869609015970 · Cited by 184 · see citing works
Initial clinical (phase I) trial of TLC D-99 (doxorubicin encapsulated in liposomes).
Cowens, J. W., Creaven, P. J., Greco, W. R., Brenner, D. E., Tung, Y., Ostro, M. J., Pilkiewicz, F. G., Ginsberg, R. S., & Petrelli, N. J. (1993) · PubMed · Cited by 136 · see citing works
Inhibition of Liposome-Induced Complement Activation by Incorporated Poly(Ethylene Glycol)-Lipids
Bradley, A. J., Devine, D. V., Ansell, S. M., Janzen, J., & Brooks, D. E. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0798 · Cited by 132 · see citing works
Amphotericin B Lipid Complex (Ablc™): A Molecular Rationale for the Attenuation of Amphotericin B Related Toxicities
Janoff, A. S., Perkins, W. R., Saletan, S., & Swenson, C. E. (1993) · Journal of Liposome Research · doi:10.3109/08982109309150730 · Cited by 122 · see citing works
Pharmacokinetic-pharmacodynamic comparison of amphotericin B (AMB) and two lipid-associated AMB preparations, liposomal AMB and AMB lipid complex, in murine candidiasis models
Andes, D., Safdar, N., Marchillo, K., & Conklin, R. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.2.674-684.2006 · Cited by 116 · see citing works
Low‐dose amphotericin b lipid complex vs. conventional amphotericin B for empirical antifungal therapy of neutropenic fever in patients with hematologic malignancies – a randomized, controlled trial
Subirá, M., Martino, R., Gómez, L., Martí, J. M., Estany, C., & Sierra, J. (2004) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2004.00239.x · Cited by 82 · see citing works
Invitro and invivo studies with adriamycin liposomes
Forssen, E. A., & Tökés, Z. A. (1979) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(79)91207-5 · Cited by 81 · see citing works
Cell-induced leakage of liposome contents
van Renswoude, J., & Hoekstra, D. (1981) · Biochemistry · doi:10.1021/bi00506a015 · Cited by 64 · see citing works
Early events in calcium-induced liposome fusion
Miller, D. C., & Dahl, G. (1982) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(82)90201-2 · Cited by 33 · see citing works
Formation of fatty acid ethyl esters during lipid extraction and storage: an important artifact
Gordon, S. G., Philippon, F., Borgen, K. S., & Kern, F. (1970) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(70)90157-8 · Cited by 24 · see citing works
Lipid-cell interactions
Margolis, L. B., Victorov, A. V., & Bergelson, L. D. (1982) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(82)90049-0 · Cited by 21 · see citing works
Rapid diffusion of the lipid phosphorus of phosphatidylglycerol liposomes through polycarbonate membranes is caused by the oxidation of the unsaturated fatty acids
Chow, C.-Y., & Heath, T. D. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00167-2 · Cited by 11 · see citing works

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Authors: Allison, S. D.
Affiliations: University of South Carolina (US)
Corresponding author: Allison, S. Dean
Venue: Journal of Infusion Nursing
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-03
Volume: 30
Issue: 2
Pages: 89-95
ISSN: 1533-1458 (ISSN-L)
DOI: 10.1097/01.nan.0000264712.26219.67
OpenAlex: W2099137306
Cited by: 45
References: 24
Citations by year: 2026: 1 · 2024: 2 · 2023: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 2
FWCI: 1.69
Type: journal article
Language: en
Open access: closed
Locations: Journal of Infusion Nursing (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: liposomal drug delivery, liposomes, phospholipids, bioavailability, long-circulating liposomes, tumor targeting, inflammation targeting, pharmacokinetics, drug toxicity, clinical efficacy
MeSH terms: Amphotericin B, Doxorubicin, Education, Continuing, Liposomes, Drug Delivery Systems

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Liposomal Drug Delivery

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