Human Papillomavirus Type Distribution in Cervical Cancer in Delhi, India
Abstract
This hospital-based study in New Delhi, North India was performed to evaluate the prevalence of human papillomavirus (HPV) in cases of invasive cervical carcinoma (ICC). A total of 10 cases presenting with an obvious cervical growth were included in this study. 108 cases that was shown to be ICC on histology (101 squamous cell carcinomas, 4 adenocarcinomas, and one neuroendocrine carcinoma) were included in the analysis. DNA was extracted from tumor tissue and HPV genotype was determined by a consensus PCR assay using a reverse line blot hybridization assay. Of 106 evaluable cases, 104 (98.1%) were positive for HPV infection. Twelve different high-risk HPV types were found. There were 125 infections, 119 of which were high risk. Six cases had associated low risk infections. HPV 16 was the commonest type, seen in 73.6% cases followed by HPV 18 (14.2%) and 45 (11.3%). A vaccine with 100% efficacy in prevention of HPV 16 and 18 infections would theoretically reduce the total cancer burden in New Delhi by more than 75% (assuming 100% coverage). Increasing the genotype spectrum (e.g. valency) if the existing vaccines would be expected to have only a modest impact on the potential for cervical protection.
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In a similar study from Delhi (north India), HPV 16 and 18 contributed 73.6 and 14.2% of cervical carcinoma cases.
“In a similar study from Delhi (north India) reported that HPV 16 and 18 contributing 73.6 and 14.2% cases of cervical carcinoma [19].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [19]
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- Authors
- Bhatla, N., Dar, L., Patro, A. R. K., Kriplani, A., Gulati, A., Verma, K., Broor, S., Shah, K. V., & Gravitt, P. E.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Johns Hopkins University (US)
- Corresponding author
- Bhatla, Neerja
- ORCID
- Venue
- International Journal of Gynecological Pathology
- Published
- 2006-10
- Volume
- 25
- Issue
- 4
- Pages
- 398-402
- ISSN
- 0277-1691 (ISSN-L)
- OpenAlex
- W2005494342
- Cited by
- 50
- References
- 0
- Citations by year
- 2025: 1 · 2024: 7 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Gynecological Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- human papillomavirus, cervical cancer, HPV genotype distribution, HPV16, HPV 18, HPV45, high-risk HPV, HPV vaccine, cervical squamous cell carcinoma, New Delhi
- MeSH terms
- Adenocarcinoma, Adult, Aged, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, DNA, Viral, Female, Genotype, Humans, India, Middle Aged, Neoplasm Staging, Risk Factors, Polymerase Chain Reaction, Papillomaviridae, Papillomavirus Infections, Human papillomavirus 18, Human papillomavirus 16
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