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Cited by 532Inflammatory Bowel DiseaseTryptophan and brain disordersOcular Diseases and Behçet’s Syndrome

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Impact of Depressive Mood on Relapse in Patients With Inflammatory Bowel Disease: A Prospective 18-Month Follow-Up Study

Mittermaier, Christian, Dejaco, Clemens, Waldhoer, Thomas, Oefferlbauer-Ernst, Anna, Miehsler, Wolfgang, Beier, Markus, Tillinger, Wolfgang, Gangl, Alfred, Moser, Gabriele·2004·Psychosomatic Medicine
DOI 10.1097/01.psy.0000106907.24881.f2
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Abstract

OBJECTIVE: There is evidence of an interaction between psychological factors and activity of inflammatory bowel disease (IBD). We examined the influence of depressive mood and associated anxiety on the course of IBD over a period of 18 months in a cohort of patients after an episode of active disease. METHODS: In this prospective, longitudinal, observational study, 60 patients (37 women and 23 men) with clinically inactive IBD (Crohn disease, n = 47, 78%; ulcerative colitis, n = 13, 22%) were enrolled after a flare of disease. Psychological status, health-related quality of life (HRQOL), and disease activity were evaluated at baseline and then every 3 months for a period of 18 months by means of clinical and biological parameters, the Beck Depression Inventory (BDI), the Spielberger State-Trait Anxiety Inventory, the Inflammatory Bowel Disease Questionnaire, the Perceived Stress Questionnaire, and the Rating Form of Inflammatory Bowel Disease Patients Concerns. RESULTS: At baseline, depression (BDI > or = 13 points) was found in 17 of 60 (28%) patients. Thirty-two patients (59%) experienced at least one relapse during the 18 months of follow-up. Regression analysis showed a significant correlation between BDI scores at baseline and the total number of relapses after 12 (p <.01) and 18 months (p <.01) of follow-up. Furthermore, depression scores at baseline correlated with the time until the first recurrence of the disease (p <.05). Anxiety and low HRQOL were also related with more frequent relapses during follow-up (p <.05 and p <.01, respectively). CONCLUSIONS: Psychological factors such as a depressive mood associated with anxiety and impaired HRQOL may exert a negative influence on the course of IBD. Therefore, assessment and management of psychological distress should be included in clinical treatment of patients with IBD.

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Crossref · 10.1097/01.psy.0000106907.24881.f2

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Research works printed but not linked: 7

  1. Kordy, 1992, Psychother Psychosom Med Psychol, 42, 141
  2. Levenstein, 1994, Am J Gastroenterol, 89, 1219
  3. Moser, 1993, Psychosom Med, 55, A131
  4. McFarlane, 1988, J Rheumatol, 15, 926
  5. Stange, 1997, Z Gastroenterol, 35, 541
  6. Cleeland, 1999, Proc Am Soc Clin Oncol, 18, A2215
  7. Stein, 1989, J Clin Psychiatry, 50, 35

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Metadata

Authors
Mittermaier, C., Dejaco, C., Waldhoer, T., Oefferlbauer-Ernst, A., Miehsler, W., Beier, M., Tillinger, W., Gangl, A., & Moser, G.
Affiliations
University of Vienna (AT)
Corresponding author
Dejaco, Clemens
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-01
Volume
66
Issue
1
Pages
79-84
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/01.psy.0000106907.24881.f2
OpenAlex
W2047170682
Cited by
532
References
44
Citations by year
2026: 4 · 2025: 11 · 2024: 19 · 2023: 15 · 2022: 28 · 2021: 30 · 2020: 18 · 2019: 27 · 2018: 38 · 2017: 34 · 2016: 35 · 2015: 36 · 2014: 26 · 2013: 28 · 2012: 31
FWCI
10.50
Type
journal article
Language
en
Open access
closed
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
inflammatory bowel disease, depressive mood, depression, anxiety, relapse, Crohn's disease, ulcerative colitis, health-related quality of life, psychological distress, disease activity
MeSH terms
Adult, Affect, Colitis, Ulcerative, Crohn Disease, Depression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Psychological Tests, Quality of Life, Recurrence, Severity of Illness Index, Inflammatory Bowel Diseases, Disease Progression

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