The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Anxiety and depression in patients with pulmonary hypertension.
Abstract
OBJECTIVE: This is the first study that investigates the prevalence and actual treatment of anxiety, depression, and other mental disorders in patients with pulmonary hypertension (PH). The prevalence of mental disorders in patients with PH was compared with parallel groups of primary care patients and patients with inflammatory rheumatic diseases, and the relationship between functional status and prevalence of mental disorders was determined. METHODS: The patient group with PH (70.1% female; mean age, 47.8 +/- 12.7 years) and the two comparison groups, which were matched by age and sex, consisted of 164 patients each. Patients completed self-administered instruments, including the Patient Health Questionnaire for the diagnosis of mental disorders. New York Heart Association (NYHA) functional class was assessed in all patients with PH. RESULTS: Thirty-five percent of the patients with PH suffered from mental disorders, with the most common being major depressive disorder (15.9%) and panic disorder (10.4%). Both panic disorder and panic attacks were significantly more prevalent in patients with PH than in either patients with inflammatory rheumatic diseases or primary care patients. The prevalence of mental disorders in patients with PH increased significantly with functional impairment, from 17.7% (NYHA class I) to 61.9% (NYHA class IV). Only 24.1% of the patients with PH with mental disorders were receiving psychopharmacological or psychotherapeutic treatment. CONCLUSIONS: Anxiety and depression are frequent in patients with PH and increase as the severity of disease progresses. Given the fact that safe and efficacious treatments of mental disorders are available, greater importance should be attached to the diagnosis and treatment of these conditions in patients with PH.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Yet, there is a lack of easily accessible evidence-based treatments.”
From Metacognitive Short-Term Intervention in Patients With Mental Disorders Following Cardiovascular Events (2022) · cites this paper as [18]
In the citing paper
“In clinical practice, only a fraction of CVD patients with a comorbid mental illness actually receives an adequate psychological treatment (5, 17, 18).”
From Metacognitive Short-Term Intervention in Patients With Mental Disorders Following Cardiovascular Events (2022) · cites this paper as [18]
Citations
Cites
Arnett, F. C., Edworthy, S. M., Bloch, D. A., McShane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A., Kaplan, S. R., Liang, M. H., Luthra, H. S., et al. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310302 · Cited by 19,753
The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519
Spitzer, R. L. (1999) · JAMA · doi:10.1001/jama.282.18.1737 · Cited by 9,802
Survival in Patients with Primary Pulmonary Hypertension
D’Alonzo, G. E., Barst, R. J., Ayres, S. M., Bergofsky, E. H., Brundage, B. H., Detre, K. M., Fishman, A. P., Goldring, R. M., Groves, B. Μ., Kernis, J. T., et al. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-5-343 · Cited by 3,488
Barst, R. J., Rubin, L. J., Long, W. A., McGoon, M. D., Rich, S., Badesch, D. B., Groves, B. Μ., Tapson, V. F., Bourge, R. C., Brundage, B. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340504 · Cited by 2,688
Inhaled Iloprost for Severe Pulmonary Hypertension
Olschewski, H., Simonneau, G., Galiè, N., HIGENBOTTAM, T. W., Naeije, R., Rubin, L. J., Nikkho, S. M., Speich, R., Hoeper, M. M., Behr, J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020204 · Cited by 1,784
Löwe, B., Kroenke, K., Herzog, W., & Gräfe, K. (2004) · Journal of Affective Disorders · doi:10.1016/s0165-0327(03)00198-8 · Cited by 1,558 · cited 1×
“Screening questionnaires like the PHQ (21) or simple diagnostic questions (35) can help identify and monitor mental disorders in medical patients (36,37).”
BackgroundDepression, Disability Days, and Days Lost From Work in a Prospective Epidemiologic Survey
Broadhead, W. E. (1990) · JAMA · doi:10.1001/jama.1990.03450190056028 · Cited by 1,232
False Suffocation Alarms, Spontaneous Panics, and Related Conditions: An Integrative Hypothesis
Klein, D. F. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820160076009 · Cited by 1,130
LOWE, B. (2004) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00237-9 · Cited by 1,060
Cited by
Sorted by citations
Items 201–229 of 229
Moon, J. R., Kang, D. R., Song, J., Huh, J., Kang, I., Chang, S., Park, S. W., & Lee, H. J. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000201
Galiè, N., Humbert, M. J. C., & Barberà, J. A. (2015)
COMPARISON OF ANTIDEPRESSANT ACTIVITY OF LOSARTAN WITH IMIPRAMINE IN ALBINO MICE
Anil, C., Balakrishna, N., Majeed, M. A., Devi, D. N., & Kondaveti, S. (2016) · Journal of Evidence Based Medicine and Healthcare · doi:10.18410/jebmh/2016/492
Cardiac catheterisation and the promotion of positive coping and self-management
Roberts‐Collins, C., Anderson, C., MacCallam, J., Randle‐Phillips, C., & Medley, A. R. (2017) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2017.12.7.342
Rehabilitación pulmonar en hipertensión pulmonar
Gómez, V., & Casas, A. (2017) · Revista Colombiana de Cardiología · doi:10.1016/j.rccar.2017.07.005
Psychiatric Aspects of Non-cardiac Thoracic Surgery
Prince, E. J., Piddoubny, W., Caro, M. A., Gerstenblith, T. A., & Bienvenu, O. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-99774-2_9
A Closer Look at the Preclinical Experience of RP5063 in Pulmonary Arterial Hypertension
Bhat, L., & Salvail, D. (2017) · Journal of Rare Diseases Research & Treatment · doi:10.29245/2572-9411/2017/5.1123
Child and Family Centered Care for Pediatric Patients Diagnosed with Pulmonary Arterial Hypertension
Doran, A. K. (2011) · Advances in Pulmonary Hypertension · doi:10.21693/1933-088x-10.2.94
Gerhardt, F., & Rosenkranz, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-43985-9_26
Caputo, A. (2020) · RICERCHE DI PSICOLOGIA · doi:10.3280/rip2020-003002
Saleemi, S., Alameer, R. M., Alsulaim, T., & ALGhasab, N. S. (2021) · medRxiv · doi:10.1101/2021.04.22.20232645
Church, C., Gin‐Sing, W., Grady, D., Johnson, M., Kiely, D. G., Lordan, J. L., Turner, N., Wort, S. J., & Condliffe, R. A. (2021) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1931129
Андреева, Е. В. (2012) · Izvestia Herzen University Journal of Humanities & Sciences
Kardiopulmonale Ausdauerkapazitätstests
van Gestel, A. J. R., Teschler, H., & Steier, J. S. (2014) · Springer eBooks · doi:10.1007/978-3-662-43678-3_21
Valkenburg, C. V. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-252-6_24
Valkenburg, C. V. (2016) · Springer eBooks · doi:10.1007/978-1-4939-2528-5_24
Kapfhammer, H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65873-4_5
Gerhardt, F., & Rosenkranz, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-13621-4_26
Update to: self-help cognitive behavioural therapy for anxiety in pulmonary hypertension
Rawlings, G. H., Bowmer, G., Armstrong, I. J., & Thompson, A. R. (2025) · ERJ Open Research · doi:10.1183/23120541.00872-2024
Pasquale, C. D., Pistorio, M. L., Veroux, M., Moretta, T., Rodolico, M. S., Monte, I. P., Barbagallo, N., Zanoli, L., Faro, D. C., Giaquinta, A., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1460260
Cardiopulmonary Exercise Testing, Rehabilitation, and Exercise Training in Postpulmonary Embolism
Dharmavaram, N. L., Esmaeeli, A., Jacobson, K. M., Brailovsky, Y., & Raza, F. (2025) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2024.12.004
Yan, Y., Sagor, M. I. H., Chen, L., Lin, H., Gao, G., Lian, G., & Xie, L. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1670519
Scelsi, L., Badagliacca, R., Vicenzi, M., Poi, E. D., Baldi, F., Ameri, P., Airò, E., Bux, F., Lorenzo, D., Giuliani, L., et al. (2026) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2025-003377
Sese, D., & Argula, R. G. (2026) · Therapeutic Advances in Respiratory Disease · doi:10.1177/17534666261438211
Saleemi, S., Alameer, R. M., Alsulaim, T., ALGhasab, N. S., & Almesned, S. (2026) · Cureus · doi:10.7759/cureus.109819
Rawlings, G. H., Armstrong, I. J., Thompson, A. R., & Kiely, D. G. (2026) · Pulmonary Circulation · doi:10.1002/pul2.70356
Naglaa, B. A., Elkorashy, R. I., & Soliman, Y. M. A. (2015) · Egyptian Journal of Chest Diseases and Tuberculosis · doi:10.1016/j.ejcdt.2015.04.005
Metadata
- Authors
- Löwe, B., Gräfe, K., Ufer, C., Kroenke, K., Grünig, E., Herzog, W., & Borst, M. M.
- Affiliations
- Heidelberg University (DE)
- Regenstrief Institute (US)
- Corresponding author
- Löwe, Bernd
- Venue
- Psychosomatic Medicine
- Published
- 2004-11
- Volume
- 66
- Issue
- 6
- Pages
- 831-836
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2059367168
- Cited by
- 230
- References
- 38
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 12 · 2021: 13 · 2020: 12 · 2019: 7 · 2018: 21 · 2017: 12 · 2016: 12 · 2015: 19 · 2014: 17 · 2013: 15 · 2012: 11
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- pulmonary hypertension, anxiety, depression, major depressive disorder, panic disorder, panic attacks, prevalence of mental disorders, NYHA functional class, functional disability, psychopharmacological treatment, psychotherapy, inflammatory rheumatic diseases, primary care patients
- MeSH terms
- Anxiety Disorders, Austria, Mental Disorders, Depressive Disorder, Female, Germany, Health Services Accessibility, Health Status, Humans, Hypertension, Pulmonary, Male, Middle Aged, Psychotherapy, Psychotropic Drugs, Surveys and Questionnaires, Severity of Illness Index, Switzerland, Comorbidity, Prevalence, Panic Disorder
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review