The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Adherence to Highly Active Antiretroviral Therapy Assessed by Pharmacy Claims Predicts Survival in HIV-Infected South African Adults
Abstract
It is unclear how adherence to highly active antiretroviral therapy (HAART) may best be monitored in large HIV programs in sub-Saharan Africa where it is being scaled up. We aimed to evaluate the association between HAART adherence, as estimated by pharmacy claims, and survival in HIV-1-infected South African adults enrolled in a private-sector AIDS management program. Of the 6288 patients who began HAART between January 1999 and August 2004, 3805 (61%) were female and 6094 (97%) were black African. HAART adherence was >or=80% for 3298 patients (52%) and 100% for 1916 patients (30%). Women were significantly more likely to have adherence>or=80% than men (54% vs 49%, P<0.001). The median (interquartile range) follow-up time was 1.8 (1.37-2.5) years. As of 1 September 2004, 222 patients had died-a crude mortality rate of 3.5%. In a multivariate Cox regression model, adherence<80% was associated with lower survival (relative hazard 3.23; 95% confidence interval: 2.37-4.39). When medication adherence was divided into 5 strata with a width of 20% each, each stratum had lower survival rates than the adjacent, higher-adherence stratum. Among other variables tested, only baseline CD4+ T-cell count was significantly associated with decreased survival in multivariate analysis (relative hazard 5.13; 95% confidence interval: 3.42-7.72, for CD4+ T-cell count 200 cells/microL). Pharmacy-based records may be a simple and effective population-level tool for monitoring adherence as HAART programs in Africa are scaled up.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., Wagener, M. M., & Singh, N. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-1-200007040-00004 · Cited by 3,289
The assessment of refill compliance using pharmacy records: Methods, validity, and applications
Steiner, J. F., & Prochazka, A. V. (1997) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00268-5 · Cited by 1,193
Bangsberg, D. R., Hecht, F. M., Charlebois, E. D., Zolopa, A. R., Holodniy, M., Sheiner, L., Bamberger, J. D., Chesney, M. A., & Moss, A. (2000) · AIDS · doi:10.1097/00002030-200003100-00008 · Cited by 1,033
Hogg, R. S. (2001) · JAMA · doi:10.1001/jama.286.20.2568 · Cited by 728
Arnsten, J. H., Demas, P. A., Farzadegan, H., Grant, R. W., Gourevitch, M. N., Chang, C., Buono, D., Eckholdt, H., Howard, A. A., & Schoenbaum, E. E. (2001) · Clinical Infectious Diseases · doi:10.1086/323201 · Cited by 637
Curran, J. W., Debas, H. T., Arya, M., Kelley, P., Knobler, S., & Pray, L. A. (2005) · Cited by 534
Correction: Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
(2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-3-200202050-00020 · Cited by 502
Sethi, A. K., Celentano, D. D., Gange, S. J., Moore, R. D., & Gallant, J. E. (2003) · Clinical Infectious Diseases · doi:10.1086/378301 · Cited by 475
Cited by
Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa
Lawn, S. D., Harries, A. D., Anglaret, X., Myer, L., & Wood, R. (2008) · AIDS · doi:10.1097/qad.0b013e32830007cd · Cited by 639
Nonadherence to antiepileptic drugs and increased mortality: Findings from the RANSOM Study
Faught, E., Duh, M. S., Weiner, J. R., Guérin, A., & Cunnington, M. C. (2008) · Neurology · doi:10.1212/01.wnl.0000319693.10338.b9 · Cited by 411
Nachega, J. B., Uthman, O. A., Peltzer, K., Richardson, L. A., Mills, E. J., Amekudzi, K., & Ouédraogo, A. (2015) · Bulletin of the World Health Organization · doi:10.2471/blt.14.138149 · Cited by 125
Self-citationParry, C. D., Morojele, N. K., Myers, B. J., Kekwaletswe, C. T., Manda, S. O., Sorsdahl, K., Ramjee, G., Hahn, J. A., Rehm, J., & Shuper, P. A. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-500 · Cited by 43
Healthcare Costs Associated with Antiretroviral Adherence Among Medicaid Patients
Pruitt, Z., Robst, J., Langland-Orban, B., & Brooks, R. G. (2015) · Applied Health Economics and Health Policy · doi:10.1007/s40258-014-0138-1 · Cited by 11
Metadata
- Authors
- Nachega, J. B., Hislop, M., Dowdy, D. W., Lo, M., Omer, S. B., Regensberg, L., Chaisson, R. E., & Maartens, G.
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2006-09
- Volume
- 43
- Issue
- 1
- Pages
- 78-84
- ISSN
- 1525-4135 (ISSN-L)
- OpenAlex
- W1980520085
- Cited by
- 270
- References
- 27
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Adherence to Highly Active Antiretroviral Therapy Assessed by Pharmacy Claims Predicts Survival in HIV-Infected South African Adults. https://app.cochat.ai/papers/10.1097/01.qai.0000225015.43266.46
- The paper
- Nachega, J. B., Hislop, M., Dowdy, D. W., Lo, M., Omer, S. B., Regensberg, L., Chaisson, R. E., & Maartens, G. (2006). Adherence to Highly Active Antiretroviral Therapy Assessed by Pharmacy Claims Predicts Survival in HIV-Infected South African Adults. JAIDS Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/01.qai.0000225015.43266.46
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
