The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Hazardous Alcohol Use: A Risk Factor for Non-Adherence and Lack of Suppression in HIV Infection
Open accessAbstract
OBJECTIVE: We examined the independent effect of alcohol and combined effects of drug and alcohol use on antiretroviral (ART) utilization, adherence, and viral suppression in an urban cohort of HIV-infected individuals. METHODS: In an observational clinical cohort, alcohol use, active drug use, and adherence were prospectively assessed at 6-month intervals. We classified hazardous alcohol use as >7 drinks/week or >3 drinks/occasion in women, and >14 drinks/week or >4 drinks/occasion in men and active drug use as any use in the previous 6 months. Our outcomes included ART utilization, 2-week adherence, and viral suppression. We used generalized estimating equations to analyze the association between independent variables and outcomes. Analyses were adjusted for age, sex, race, years on ART, and clinic enrollment time. RESULTS: Between 1998 and 2003, 1711 individuals participated in 5028 interviews. 1433 of these individuals received ART accounting for 3761 interviews. The prevalence of any alcohol use at the first interview was 45%, with 10% classified as hazardous drinkers. One-third of the sample used illicit drugs. In multivariate analyses adjusting for age, sex, race, active drug use, years on ART, and clinic enrollment time, hazardous alcohol use was independently associated with decreased ART utilization (AOR, 0.65; 95% CI: 0.51 to 0.82), 2-week adherence (AOR, 0.46; 95% CI: 0.34 to 0.63), and viral suppression (AOR, 0.76; 95% CI: 0.57 to 0.99) compared to no alcohol use. Concurrent injection drug use (IDU) exacerbated this negative effect on ART use, adherence, and suppression. CONCLUSIONS: Hazardous alcohol use alone and combined with IDU was associated with decreased ART uptake, adherence, and viral suppression. Interventions targeting alcohol use may improve HIV outcomes in individuals with hazardous alcohol use.
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Cites
Longitudinal Data Analysis for Discrete and Continuous Outcomes
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Self-citationBertholet, N. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.9.986 · Cited by 710
A prospective study of predictors of adherence to combination antiretroviral medication
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Arnsten, J. H., Demas, P. A., Grant, R. W., Gourevitch, M. N., Farzadegan, H., Howard, A. A., & Schoenbaum, E. E. (2002) · Journal of General Internal Medicine · doi:10.1007/s11606-002-0044-3 · Cited by 501
Galvan, F. H., Bing, E. G., Fleishman, J. A., London, A. S., Caetano, R., Burnam, M. A., Longshore, D., Morton, S. C., Orlando, M., & Shapiro, M. (2002) · Journal of Studies on Alcohol · doi:10.15288/jsa.2002.63.179 · Cited by 438
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Detrimental Effects of Continued Illicit Drug Use on the Treatment of HIV-1 Infection
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Self-citationLucas, G. M., Gebo, K. A., Chaisson, R. E., & Moore, R. D. (2002) · AIDS · doi:10.1097/00002030-200203290-00012 · Cited by 320
Self-citationSpire, B., Duran, S., Souville, M., Leport, C., Raffi, F., & Moatti, J.-P. (2002) · Social Science & Medicine · doi:10.1016/s0277-9536(01)00125-3 · Cited by 296
Cited by
Azar, M. M., Springer, S. A., Meyer, J. P., & Altice, F. L. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.06.014 · Cited by 394
Williams, E. C., Hahn, J. A., Saitz, R., Bryant, K., Lira, M. C., & Samet, J. H. (2016) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13204 · Cited by 294
Duko, B., Ayalew, M., & Ayano, G. (2019) · Substance Abuse Treatment, Prevention, and Policy · doi:10.1186/s13011-019-0240-3 · Cited by 209
Alcohol and HIV Disease Progression: Weighing the Evidence
Hahn, J. A., & Samet, J. H. (2010) · Current HIV/AIDS Reports · doi:10.1007/s11904-010-0060-6 · Cited by 181
Crane, H. M., McCaul, M. E., Chander, G., Hutton, H., Nance, R. M., Delaney, J. A. C., Merrill, J. O., Lau, B., Mayer, K. H., Mugavero, M. J., et al. (2017) · AIDS and Behavior · doi:10.1007/s10461-017-1740-7 · Cited by 125
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Metadata
- Authors
- Chander, G., Lau, B., & Moore, R. D.
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2006-12-01
- Volume
- 43
- Issue
- 4
- Pages
- 411-417
- ISSN
- 1525-4135 (ISSN-L)
- OpenAlex
- W2040512636
- Cited by
- 320
- References
- 28
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- green
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