The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Longitudinal assessment of the effects of drug and alcohol abuse on HIV-1 treatment outcomes in an urban clinic
Abstract
OBJECTIVE: To assess the temporal association of changes in substance abuse with antiretroviral therapy use and adherence, HIV-1 RNA suppression, and CD4 cell count changes in patients attending an urban clinic. DESIGN: Prospective cohort study. METHODS: Six-hundred and ninety-five HIV-1-infected individuals, who completed two or more semi-annual standardized surveys and in whom antiretroviral therapy was indicated, were included in the analysis. Surveys addressed antiretroviral therapy use and adherence, and use of illicit drugs and alcohol. Substance abuse was defined as active heroin, cocaine, or heavy alcohol use in the 6 months preceding survey. The units of analysis were consecutive pairs of surveys (couplets) in individual participants. Couplets in which participants denied substance abuse in both surveys were compared to couplets in which participants switched from non-use to substance abuse, and couplets in which participants reported substance abuse in both surveys were compared to couplets where participants switched from substance abuse to non-use. RESULTS: Switching from non-use to substance abuse was strongly associated with worsening antiretroviral therapy use and adherence, less frequent HIV-1 RNA suppression, and blunted CD4 cell increases, compared to remaining free of substance abuse. Alternatively, switching from substance abuse to non-use was strongly associated with improvements in antiretroviral therapy use and adherence, and HIV-1 treatment outcomes, compared to persisting with substance abuse. CONCLUSIONS: This longitudinal study highlights the dynamic nature of substance abuse and its temporal association with the effectiveness of HIV-1 treatment in patients attending an inner-city clinic.
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Cites
Longitudinal Data Analysis for Discrete and Continuous Outcomes
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Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
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Self-citationHirsch, M. S., Brun-Vézinet, F., D'Aquila, R. T., Hammer, S. M., Johnson, V. A., Kuritzkes, D. R., Loveday, C., Mellors, J. W., Clotet, B., Conway, B., et al. (2000) · JAMA · doi:10.1001/jama.283.18.2417 · Cited by 766
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Self-citationDetrimental Effects of Continued Illicit Drug Use on the Treatment of HIV-1 Infection
Lucas, G. M., Cheever, L. W., Chaisson, R. E., & Moore, R. D. (2001) · Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00042560-200107010-00006 · Cited by 350
Self-citationProblem Drinking and Medication Adherence Among Persons with HIV Infection
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Cited by
Altice, F. L., Kamarulzaman, A., Soriano, V. V., Schechter, M., & Friedland, G. H. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60829-x · Cited by 504
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Self-citationHazardous Alcohol Use: A Risk Factor for Non-Adherence and Lack of Suppression in HIV Infection
Chander, G., Lau, B., & Moore, R. D. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000243121.44659.a4 · Cited by 320
Self-citationCrack-Cocaine Use Accelerates HIV Disease Progression in a Cohort of HIV-Positive Drug Users
Baum, M. K., Rafie, C., Lai, S., Sales, S., Page, B., & Campa, A. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181900129 · Cited by 255
Reynolds, N. R., Testa, M. A., Marc, L. G., Chesney, M. A., Neidig, J. L., Smith, S. R., Vella, S., Robbins, G. K., & Protocol Teams of ACTG 384, A. 7. (2004) · AIDS and Behavior · doi:10.1023/b:aibe.0000030245.52406.bb · Cited by 204
Metadata
- Authors
- Lucas, G. M., Gebo, K. A., Chaisson, R. E., & Moore, R. D.
- Venue
- AIDS
- Published
- 2002-03
- Volume
- 16
- Issue
- 5
- Pages
- 767-774
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2055135903
- Cited by
- 320
- References
- 29
- FWCI
- 11.98
- Type
- journal article
- Language
- en
- Open access
- closed
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