Incidence of Nonvertebral Fractures in Relation to Time on Treatment and Bone Density in Glucocorticoid-Treated Patients: A Retrospective Approach
Abstract
The effects of duration of treatment and bone mineral density (BMD) on nonvertebral fracture in 560 glucocorticoid users were examined by using baseline and retrospective data from 2 parallel studies assessing the efficacy and safety of alendronate therapy. Baseline spine and hip BMD were significantly (P < 0.01) lower with increased time spent receiving glucocorticoids. Forty-three patients (7.7%) had experienced at least 1 nonvertebral fracture after starting glucocorticoid treatment. The hazard function for nonvertebral fracture occurrence increased significantly (P < 0.01) with time spent receiving glucocorticoids: fracture incidence per 1,000 person-years on glucocorticoids was 18 (< 5 years), 31 (5-10 years), and 35 (> 10 years). Patients with a history of nonvertebral fractures after starting glucocorticoid treatment had significantly lower lumbar spine (P < 0.01) and hip (< 0.01) BMD value than those without fractures. This retrospective analysis suggests that a BMD measurement of spine and hip may identify risk for nonvertebral fractures in a heterogeneous population of glucocorticoid users.
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Glucocorticoid use results in rapid trabecular bone loss and a high incident fracture risk.
“However, GC use results in rapid trabecular bone loss and a high incident fracture risk [1, 2].”
From Prevention of glucocorticoid induced bone changes with beta-ecdysone (2015) · cites this paper as [1]
Cites
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Prevention of glucocorticoid induced bone changes with beta-ecdysone
Dai, W., Jiang, L., Lay, Y.-A. E., Chen, H., Jin, G., Zhang, H., Kot, A., Ritchie, R. O., Lane, N. E., & Yao, W. (2015) · Bone · doi:10.1016/j.bone.2015.01.001 · Cited by 30 · see citing works
Self-citation
- Authors
- Goemaere, S., Liberman, U. A., Adachi, J. D., Hawkins, F., Lane, N., Saag, K. G., Schnitzer, T., Kaufman, J. M., Malice, M. P., Carofano, W., & Daifotis, A.
- Affiliations
- Ghent University Hospital (BE)
- Rabin Medical Center (IL)
- St. Joseph’s Healthcare Hamilton (CA)
- Universidad Complutense de Madrid (ES)
- University of California, San Francisco (US)
- University of Alabama (US)
- Corresponding author
- Goemaere, S.
- Schnitzer, T.
- Kaufman, J. M.
- Venue
- JCR Journal of Clinical Rheumatology
- Published
- 2003-06
- Volume
- 9
- Issue
- 3
- Pages
- 170-175
- ISSN
- 1076-1608 (ISSN-L)
- OpenAlex
- W2008908780
- Cited by
- 7
- References
- 13
- Citations by year
- 2021: 1 · 2020: 1 · 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JCR Journal of Clinical Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- non-vertebral fractures, glucocorticoid-induced osteoporosis, bone mineral density, fracture risk, alendronate, lumbar spine bone mineral density, hip bone density, fracture incidence
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