The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Insulin Independence Following Isolated Islet Transplantation and Single Islet Infusions
Open accessAbstract
Objective To restore islet function in patients whose labile diabetes subjected them to frequent dangerous episodes of hypoglycemic unawareness, and to determine whether multiple transplants are always required to achieve insulin independence. Summary background data The recent report by the Edmonton group documenting restoration of insulin independence by islet transplantation in seven consecutive patients with type 1 diabetes differed from previous worldwide experience of only sporadic success. In the Edmonton patients, the transplanted islet mass critical for success was approximately more than 9,000 IEq/kg of recipient body weight and required two or three separate transplants of islets isolated from two to four cadaveric donors. Whether the success of the Edmonton group can be recapitulated by others, and whether repeated transplants using multiple donors will be a universal requirement for success have not been reported. Methods The authors report their treatment with islet transplantation of nine patients whose labile type 1 diabetes was characterized by frequent episodes of dangerous hypoglycemia. Results In each of the seven patients who have completed the treatment protocol (i.e., one or if necessary a second islet transplant), insulin independence has been achieved. In five of the seven patients only a single infusion of islets was required. To date, only one recipient has subsequently lost graft function, after an initially successful transplant. This patient suff…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Assuming a similar dose as with human islets from deceased donors,175,176 on the order of 109 cells will be required per patient.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [175]
Citations
Cites
Successful Islet Transplantation
Ryan, E. A., Lakey, J. R. T., Paty, B. W., Imes, S., Korbutt, G. S., Kneteman, N. M., Bigam, D., Rajotte, R. V., & Shapiro, A. M. J. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2148 · Cited by 719
Research works printed but not linked: 23
- Kelly, 1967, Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy, Surgery, 61, 827
- Gruessner, 2000, Pancreas transplant outcome for United State (US) cases reported to the United Network for Organ Sharing (UNOS) and non-US cases reported to the International Pancreas Transplant Registry (IPTR) as of October 2000, Clin Transplant, 4, 45
- Kendall, 1996, Pancreas and islet transplantation in humans, Diabetes Metab Rev, 22, 157
- Solders, 1995, Improvement in nerve conduction 8 years after combined pancreatic and renal transplantation, Transplant Proc, 27, 3091
- Sutherland, 1992, Effects of pancreas transplants on secondary complications of diabetes: Review of observations at a single institution, Transplant Proc, 24, 859
- Ramsay, 1988, Progression of diabetic retinopathy after pancreas transplantation for insulin-dependent diabetes mellitus, N Engl J Med, 318, 208, 10.1056/NEJM198801283180403 · DOI
- Bilous, 1989, The effects of pancreas transplantation on the glomerular structure of renal allografts in patients with insulin-dependent diabetes, N Engl J Med, 321, 80, 10.1056/NEJM198907133210204 · DOI
- Smet, 1999, Effects of simultaneous pancreas kidney transplantation on mortality of patients with type I diabetes mellitus and end-stage renal failure, Lancet, 353, 1915, 10.1016/S0140-6736(98)07513-8 · DOI
- Tyden, 1999, Improved survival in patients with insulin-dependent diabetes mellitus and end-stage diabetic nephropathy 10 years after combined pancreas and kidney transplantation, Transplantation, 67, 645, 10.1097/00007890-199903150-00001 · DOI
- Rayhill, 2000, Simultaneous pancreas-kidney transplantation and living related donor renal transplantation in patients with diabetes: Is there a difference in survival?, Ann Surg, 231, 417, 10.1097/00000658-200003000-00015 · DOI
- Fioretto, 1998, Reversal of lesions of diabetic nephropathy after pancreas transplantation, N Engl J Med, 339, 69, 10.1056/NEJM199807093390202 · DOI
- Humar, 2000, Decreased surgical risks of pancreas transplantation in the modern era, Ann Surg, 231, 269, 10.1097/00000658-200002000-00017 · DOI
- Ballinger, 1972, Transplantation of intact pancreatic islets in rats, Surgery, 72, 175
- Hering, 1999, Islet transplantation for patients with type 1 diabetes, Graft Review, 2, 12
- Shapiro, 2000, Islet transplantation in seven patients with type I diabetes mellitus using a glucocorticoid-free immunosuppressive regimen, N Engl J Med, 343, 230, 10.1056/NEJM200007273430401 · DOI · Paper page
- Ryan, 2001, Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol, Diabetes, 50, 710, 10.2337/diabetes.50.4.710 · DOI
- Ricordi, 1989, Automated islet isolation from human pancreas, Diabetes, 38, 140, 10.2337/diab.38.1.S140 · DOI
- Linetsky, 1997, Improved human islet isolation using a new enzyme blend, Liberase, Diabetes, 46, 1120, 10.2337/diab.46.7.1120 · DOI
- Kaufman, 2002, Sequential kidney/islet transplantation using prednisone-free immunosuppression, Am J Transplant, 2, 674, 10.1034/j.1600-6143.2002.20715.x · DOI
- Casey, 2002, Portal venous pressure changes sequential clinical islet transplantation, Transplantation, 74, 913, 10.1097/00007890-200210150-00002 · DOI
- Davalli, 1995, A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice, Transplantation, 59, 817, 10.1097/00007890-199503000-00003 · DOI
- Centreras, 2001, Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement, Surgery, 130, 167
- Pileggi, 2001, Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation, Diabetes, 50, 1983, 10.2337/diabetes.50.9.1983 · DOI
Cited by
Sorted by citations
Items 101–168 of 168
Chen, X.-B., Li, Y.-X., Jiao, Y., Dong, W., Li, G., Chen, J., & Tan, J.-M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i7.1053 · Cited by 21
Froud, T., Baidal, D. A., Ponte, G., Ferreira, J. V., Ricordi, C., & Alejandro, R. (2006) · Cell Transplantation · doi:10.3727/000000006783981639 · Cited by 34
Update on Regulatory Issues in Pancreatic Islet Transplantation
Wonnacott, K. (2005) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000178765.60234.39 · Cited by 21
Lobo, P. I., Spencer, C. E., Simmons, W., Hagspiel, K. D., Angle, J. F., Deng, S. L., Markmann, J. F., Naji, A., Kirk, S. E., Pruett, T. L., et al. (2005) · Transplantation Proceedings · doi:10.1016/j.transproceed.2005.09.065 · Cited by 21
Self-citationGillard, P., Ling, Z., Lannoo, M., Maes, B., Maleux, G., Pipeleers, D., Keymeulen, B., & Mathieu, C. (2004) · Diabetes Care · doi:10.2337/diacare.27.9.2243 · Cited by 19
Nonhuman Primate Models in Type 1 Diabetes Research
Contreras, J. L., Smyth, C. A., Curiel, D. T., & Eckhoff, D. E. (2004) · ILAR Journal · doi:10.1093/ilar.45.3.334 · Cited by 17
“The only way at present to restore sustained normoglycemia without the risk associated with hypoglycemia (as seen with intensive insulin therapy), and without procedural complications (as seen in pancreas transplantation), is to perform an isolated pancreatic islet transplant (PIT) (Bertuzzi et al. 1999; Bretzel et al…”
BackgroundPharmacologically regulated regeneration of functional human pancreatic islets.
Kobinger, G., Deng, S., Louboutin, J., Vatamaniuk, M., Rivera, V., Lian, M.-M., Markmann, J., Clackson, T., Raper, S., Matschinsky, F., et al. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2004.09.010 · Cited by 17
“Pancreatic islets were isolated using a modification of the automated Ricordi method [24].”
MethodSelf-citationBarker, C., & Kaiser, L. (2004) · doi:10.1016/j.jamcollsurg.2003.08.021 · Cited by 17
Self-citationShenkman, R., Godoy-Silva, R., Papas, K., & Chalmers, J. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22241 · Cited by 16
“It has been suggested that treatments that reverse hyperglycemia may retard or even reverse these diabetic complications (Markmann et al., 2003).”
The spleen--a potential source of new islets for transplantation?
Robertson, S. A., Rowan-Hull, A., & Johnson, P. R. V. (2008) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2007.10.013 · Cited by 16
Single-donor islet transplantation in type 1 diabetes: patient selection and special considerations
Tatum, J. A., Meneveau, M. O., & Brayman, K. L. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s105692 · Cited by 17
“The volume of infused islets correlates to the duration of insulin independence post-transplant.(20) Therefore, a barrier to islet transplantation has been the need for recurrent islet infusions due to decreasing graft function over time.”
BackgroundSelf-citationArchibald, P., & Williams, D. (2015) · Regenerative Medicine · doi:10.2217/rme.15.59 · Cited by 15
Pancreatic islet transplantation
Noguchi, H. (2009) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v1.i1.16 · Cited by 32
Islet transplantation: Current status and future directions
Hatipoğlu, B., Benedetti, E., & Oberholzer, J. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0029-9 · Cited by 13
In Vivo Imaging of Pancreatic Islet Grafts in Diabetes Treatment
Arifin, D., & Bulte, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.640117 · Cited by 12
“At present, clinical trials rely on blood glucose levels and metabolic tests before and after transplantation to gauge the therapeutic performance (8, 9).”
Cellular Immunoisolation for Islet Transplantation by a Novel Dual Porosity Electrospun Membrane
Krishnan, L., Clayton, L. R., Boland, E. D., Reed, R. M., Hoying, J. B., & Williams, S. K. (2011) · Transplantation Proceedings · doi:10.1016/j.transproceed.2011.10.031 · Cited by 14
Scharp, D. W., Arulmoli, J., Morgan, K. N., Sunshine, H., & Hao, E. (2019) · OBM Transplantation · doi:10.21926/obm.transplant.1901052 · Cited by 15
Marathe, C., Drogemuller, C., Marathe, J., Loudavaris, T., Hawthorne, W. J., O'Connell, P., Radford, T., Kay, T., Horowitz, M., Coates, P. T., et al. (2014) · Hormone and Metabolic Research · doi:10.1055/s-0034-1389941 · Cited by 10
Autologous and Allogenous Antibodies in Lung and Islet Cell Transplantation
Nayak, D. K., Saravanan, P. B., Bansal, S., Naziruddin, B., & Mohanakumar, T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00650 · Cited by 10
“Despite significant advances in the islet isolation protocol, islets isolated from more than one donor pancreas are often required to achieve insulin-independent status (86), and a majority of islet transplant recipients return to some form of exogenous insulin usage within a few years of transplantation due to chroni…”
BackgroundCulture and Transportation of Human Islets Between Centers
Ichii, H., Pileggi, A., Khan, A., Fraker, C. A., & Ricordi, C. (2007) · CRC Press eBooks · doi:10.3109/9781420016512-15 · Cited by 9
Carter, J. T., Karmiol, S., Nagy, M. S., McElreath, R., Calloway, C. W., Motley, A., Neill, A. C., Jang, H. J., Posselt, A. M., & Stock, P. G. (2005) · Transplantation Proceedings · doi:10.1016/j.transproceed.2005.09.073 · Cited by 8
Insulin independence following islet transplantation improves long‐term metabolic outcomes
Stanley, A. K., Duncan, K., Anderson, D., Irvine, L., Sutherland, A., Forbes, S., & Casey, J. (2023) · Diabetic Medicine · doi:10.1111/dme.15257 · Cited by 8
“27,28 It would be useful to investigate the impact of infused islet mass, number of transplants and time between transplants on post-transplant insulin requirement further, in order to shed light on this.”
BackgroundSong, S., Yeung, R., Park, J., Posselt, A., Desai, T., Tang, Q., & Roy, S. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00814 · Cited by 8
Availability of Suitable Islet Donors in the United States
Porrett, P., Yeh, H., Frank, A., Deng, S., Kim, J. I., Barker, C., & Markmann, J. (2007) · Transplantation · doi:10.1097/01.tp.0000269612.84906.4a · Cited by 8
Self-citationYang, L., Liu, Y.-F., Wu, G., Zhang, J., Wang, F.-S., Fu, D.-Z., Zhao, G.-H., & Li, T.-M. (2007) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.10.193 · Cited by 8
Exenatide use in islet transplantation: words of caution.
Rickels, M., & Naji, A. (2009) · Transplantation · doi:10.1097/tp.0b013e318191eb48 · Cited by 7
“Because single donor insulin independence has also been reported in the absence of exenatide (8, 9), randomizedcontrolled trials remain necessary to determine whether exenatide use may be associated with long-term beneficial effects on islet graft function or survival.”
BackgroundSelf-citationEffect of Islet Transplantation on Metabolic Glucose Control in Rats with Diabetes
Cornolti, R., Cattaneo, I., Trudu, M., Figliuzzi, M., & Remuzzi, A. (2009) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2009.0068 · Cited by 6
What's new in general surgery: transplantation.
Schulak, J. (2005) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2004.11.008 · Cited by 6
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy
So, W. Y., Liao, Y., Liu, W. N., Rutter, G. A., & Han, W. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202317928 · Cited by 6
“Generally, multiple islet donors are required in a single transplantation to achieve insulin independence (Shapiro et al , 2000; Markmann et al , 2003), primarily because a substantial portion of the transplanted islets undergo apoptosis due to the exposure to a toxic environment of hyperglycemia,…”
BackgroundPancreas and islet cell transplantation.
Larson-Wadd, K., & Belani, K. (2004) · Anesthesiology Clinics of North America · doi:10.1016/j.atc.2004.06.010 · Cited by 5
“However with advances in immunosuppression and isolation techniques, favorable outcomes have been reported [10,40–44].”
BackgroundMethodInfluentialRizzari, M., Suszynski, T. M., Kidder, L., Stein, S., O'Brien, T., Sajja, V. S., Scott, W., Kirchner, V., Weegman, B., Avgoustiniatos, E., et al. (2010) · Transplantation Proceedings · doi:10.1016/j.transproceed.2010.09.138 · Cited by 4
“Currently, few institutions are able to treat T1D with islets from a single donor pancreas (1,2).”
BackgroundNaqvi, R., & Naqvi, A. (2023) · bioRxiv · doi:10.1101/2023.01.24.525444 · Cited by 3
Defining the chromatin and transcriptional landscape of stem cell-derived islets
Augsornworawat, P., Hogrebe, N., Ishahak, M., Marquez, E., Maestas, M. M., Schmidt, M. D., Veronese-Paniagua, D. A., Gale, S., Miller, J. R., Velazco-Cruz, L., et al. (2022) · bioRxiv · doi:10.1101/2022.02.26.482126 · Cited by 3
Successful Islet Outcomes Using Australia-Wide Donors: A National Centre Experience
Hawthorne, W. J., Davies, S., Mun, H., Chew, Y. V., Williams, L. J., Anderson, P., Rogers, N. M., & O’Connell, P. J. (2021) · Metabolites · doi:10.3390/metabo11060360 · Cited by 3
“CIT has been shown to have an adverse outcome on islet isolation in both single-centre and registry studies [1,9].”
BackgroundControversies in Treating Diabetes
LeRoith, D., & Vinik, A. I. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-572-5 · Cited by 11
Ghorbani, R., Jalili, C., Salahshoor, M., & Shiasi, M. (2015) · Advanced Biomedical Research · doi:10.4103/2277-9175.156657 · Cited by 3
“[8] In recent years, separation of islets has been one of the most applicable cases of pancreas cell separation for the purpose of transplantation to treat human diabetes type 1.[9] After separating the islets, it is possible to change the immunogenicity of cells, to increase their immune functions and to isolate immu…”
Long‐term Outcomes after Islet Transplantation
Shapiro, A. M. J., & Ricordi, C. (2014) · Wiley eBooks · doi:10.1002/9781118873434.ch108 · Cited by 3
Optimal device and method for transportation of isolated porcine islet.
Kim, T.-S., Lee, H.-S., Oh, S.-H., Moon, H., Lee, S., Song, S., Shin, M., Park, J., Kim, S.-J., Joh, J., et al. (2013) · Transplantation Proceedings · doi:10.1016/j.transproceed.2013.08.083 · Cited by 3
Islet Cell Therapy and Pancreatic Stem Cells
Domínguez‐Bendala, J., Pileggi, A., & Ricordi, C. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381422-7.10023-9 · Cited by 4
Presence of Hyperemic Islets in Human Donor-Pancreata Results in Reduced Islet Isolation Yield
Hilling, D., Töns, H. A., de Mheen, P. M. D., Baranski, A., van den Akker, E. K., Terpstra, O., & Bouwman, E. (2011) · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · doi:10.1055/s-0030-1270451 · Cited by 3
Current status of clinical islet transplantation: advances and obstacles
Wiseman, A. C., & Gill, R. G. (2004) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000129642.42263.66 · Cited by 3
[Pancreatic islets transplantation in the treatment of diabetes mellitus: present and future].
Casanova, D. (2009) · Cirugia Española · doi:10.1016/j.ciresp.2008.07.006 · Cited by 2
Maestas, M. M., Bradley, K., Shunkarova, M., Mukherjee, N., Ishahak, M., Lu, J., & Millman, J. R. (2026) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szag012 · Cited by 2
Domínguez-Bendala, J. (2009) · doi:10.1007/978-1-60761-132-5 · Cited by 2
The Surgical Aspects of Pancreas Procurement for Pancreatic Islet Transplantation
Barshes, N., Lee, T. C., Udell, I., O'Mahony, C., Brunicardi, F., & Goss, J. (2007) · CRC Press eBooks · doi:10.3109/9781420016512-5 · Cited by 2
The continuing progress and challenges of clinical islet transplantation
Wiseman, A., & Gill, R. (2005) · doi:10.1097/01.med.0000170499.89309.cb · Cited by 2
Beta cell replacement for Type I diabetes: islet versus solid organ pancreas
Stock, P. G. (2005) · Current Opinion in Organ Transplantation · doi:10.1097/01.mot.0000164190.94216.f9 · Cited by 4
Advances in Clinical Islet Isolation
Pepper, A. R., Gala-López, B., & Kin, T. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_20 · Cited by 2
Liu, E. H., & Harlan, D. M. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-572-5_2 · Cited by 3
Cell Replacement Therapy in Type 1 Diabetes
Linetsky, E., Inverardi, L., & Ricordi, C. (2013) · InTech eBooks · doi:10.5772/54943 · Cited by 1
“In the last decade or so sophisticated immunosuppressive regiments have been developed to protect allogeneic islet grafts obtained from deceased donors [46-50] long term, following transplantation.”
BackgroundImmune and cell therapy in type 1 diabetes: too little too late?
Gillard, P., & Mathieu, C. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.560568 · Cited by 1
“1 Clinical studies The potential of b-cell transplantation has been extensively demonstrated in numerous clinical trials, although including small numbers of patients [52-64].”
BackgroundBalamurugan, A. N., Loganathan, G., Tweed, B., Tucker, W. W., Venugopal, S., Mokshagundam, S. P., Hughes, M. G., & Williams, S. K. (2019) · Organ and tissue transplantation · doi:10.1007/978-3-319-05257-1_2009
Sugianto, A. S., rin, M., & Ierino, F. L. (2016) · International Journal of Diabetes & Metabolic Disorders · doi:10.33140/ijdmd/00017 · Cited by 1
“Table 10: Outcome measures of islet cell transplantation in case series study [25].”
BackgroundIslet Cell Therapy and Pancreatic Stem Cells
Domínguez‐Bendala, J., Pileggi, A., & Ricordi, C. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385942-6.00070-6 · Cited by 5
Chapter 101 – Whole-organ pancreas and pancreatic islet transplantation
Desai, N., & Markmann, J. (2012) · doi:10.1016/b978-1-4377-1454-8.00101-6 · Cited by 1
Self-citationAshkar, K., Camacho, M., Jith, D., & Bayar, Y. (2024) · Proceedings of London International Conferences · doi:10.31039/plic.2024.11.255
Chapter 88 – Leukocyte Chimerism—Meaning and Consequences
Starzl, T., Murase, N., Eghtesad, B., Abu-Elmagd, K., Demetris, A., & Fung, J. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-0268-8.00088-9
Medawar Prize acceptance speech.
Barker, C. (2010) · Transplantation · doi:10.1097/tp.0b013e3181fdda2e
Self-citationPancreas and Islet Transplantation
Harland, R. C., & Garfinkel, M. R. (2008) · Springer eBooks · doi:10.1007/978-0-387-68113-9_85 · Cited by 8
Part II of Debate: Laparoscopic Roux-en-Y Gastric Bypass
DeMaria, E. (2005) · CRC Press eBooks · doi:10.3109/9780203025758-16
Tolerance induction to pancreatic islet allografts
Coulombe, M., & Gill, R. G. (2004) · Current Opinion in Organ Transplantation · doi:10.1097/01.mot.0000137838.95174.4f
Impact of Islet Cell Transplantation on Diabetic Retinopathy in Type 1 Diabetes
Begg, I. S., Warnock, G. L., & Thompson, D. M. (2011) · Springer eBooks · doi:10.1007/978-1-60761-150-9_20 · Cited by 1
Reversal of Diabetes: Islet Cell Transplantation
Pileggi, A., Alejandro, R., & Ricordi, C. (2012) · doi:10.1007/978-1-4614-1028-7_16
Pancreas and Islet Cell Transplantation
Sutherland, D. E. R., Gruessner, A. C., Hering, B. J., & Gruessner, R. W. G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-323-07255-7.00047-7 · Cited by 1
The role of islet amyloid and CHOP in islet graft dysfunction and failure
Potter, K. (2011) · doi:10.14288/1.0072016
“Patients receiving fewer islets are less likely to become insulin-independent and allograft recipients with single donor islet infusions have poorer long-term outcomes (319).”
BackgroundRemaining Challenges and Clinical Perspectives
Domínguez‐Bendala, J. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-132-5_8
Chapter 25 Islet Transplantation for the Treatment of Type I Diabetes
Toso, C., & Shapiro, A. M. J. (2008) · Technical report · doi:10.1016/s1571-5078(07)00225-5
Pancreas and Islet Cell Transplantation
Sutherland, D. E. R., Gruessner, A. C., Hering, B. J., & Gruessner, R. W. G. (2006) · Elsevier eBooks · doi:10.1016/b978-0-323-02842-4.50047-4 · Cited by 1
Metadata
- Authors
- Markmann, J. F., Deng, S., Huang, X., Desai, N. M., Velidedeoglu, E. H., Lui, C., Frank, A., Markmann, E., Palanjian, M., Brayman, K., Wolf, B., Bell, E., Vitamaniuk, M., Doliba, N., Matschinsky, F., Barker, C. F., & Naji, A.
- Affiliations
- Hospital of the University of Pennsylvania (US)
- University of Pennsylvania (US)
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania Health System (US)
- Corresponding author
- Markmann, James F.
- Deng, Shaoping
- Huang, Xiaolun
- Desai, Niraj M.
- Lui, Chengyang
- Frank, Adam
- Markmann, Eileen
- Palanjian, Maral
- Brayman, Kenneth
- Barker, Clyde F.
- Naji, Ali
- ORCID
- Venue
- Annals of Surgery
- Published
- 2003-06
- Volume
- 237
- Issue
- 6
- Pages
- 741-750
- ISSN
- 0003-4932 (ISSN-L)
- PMC
- PMC1514687
- OpenAlex
- W2324941813
- Cited by
- 175
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 7 · 2012: 5
- FWCI
- 19.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Surgery (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pennsylvania
- National Center for Research Resources (M01-RR-00040, 1U42 RR 16600, M01RR000040, U42RR016600)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- islet transplantation, insulin independence, type 1 diabetes, hypoglycemia, hypoglycemia unawareness, graft function, islet mass
- MeSH terms
- Adult, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 1, Humans, Immunosuppressive Agents, Islets of Langerhans Transplantation, Recovery of Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
