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Insulin Independence Following Isolated Islet Transplantation and Single Islet Infusions
Open accessAbstract
Objective To restore islet function in patients whose labile diabetes subjected them to frequent dangerous episodes of hypoglycemic unawareness, and to determine whether multiple transplants are always required to achieve insulin independence. Summary background data The recent report by the Edmonton group documenting restoration of insulin independence by islet transplantation in seven consecutive patients with type 1 diabetes differed from previous worldwide experience of only sporadic success. In the Edmonton patients, the transplanted islet mass critical for success was approximately more than 9,000 IEq/kg of recipient body weight and required two or three separate transplants of islets isolated from two to four cadaveric donors. Whether the success of the Edmonton group can be recapitulated by others, and whether repeated transplants using multiple donors will be a universal requirement for success have not been reported. Methods The authors report their treatment with islet transplantation of nine patients whose labile type 1 diabetes was characterized by frequent episodes of dangerous hypoglycemia. Results In each of the seven patients who have completed the treatment protocol (i.e., one or if necessary a second islet transplant), insulin independence has been achieved. In five of the seven patients only a single infusion of islets was required. To date, only one recipient has subsequently lost graft function, after an initially successful transplant. This patient suff…
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“Assuming a similar dose as with human islets from deceased donors,175,176 on the order of 109 cells will be required per patient.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [175]
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Cited by
Sorted by citations
Five-Year Follow-Up After Clinical Islet Transplantation
Ryan, E. A., Paty, B. W., Senior, P. A., Bigam, D., Alfadhli, E., Kneteman, N. M., Lakey, J. R. T., & Shapiro, A. M. J. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2060 · Cited by 1,641
Single-Donor, Marginal-Dose Islet Transplantation in Patients With Type 1 Diabetes
Hering, B. J. (2005) · JAMA · doi:10.1001/jama.293.7.830 · Cited by 595
Islet Transplantation as a Treatment for Diabetes — A Work in Progress
Robertson, R. P. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032425 · Cited by 434
Froud, T., Ricordi, C., Baidal, D. A., Hafiz, M. M., Ponte, G., Cure, P., Pileggi, A., Poggioli, R., Ichii, H., Khan, A., et al. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00957.x · Cited by 386
Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects
Deng, S., Vatamaniuk, M. Z., Huang, X., Doliba, N. M., Lian, M.-M., Frank, A. M., Velidedeoğlu, E., Desai, N. M., Koeberlein, B., Wolf, B. A., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.3.624 · Cited by 346
“The recent success of islet transplantation relies on the delivery of a large number of islets and usually requires all of the islets that can be obtained by processing two to four pancreata (28,32).”
BackgroundSelf-citationBarshes, N., Wyllie, S., & Goss, J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1104649 · Cited by 331
“with pancreatic islets from a single donor [7].”
Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions
Rickels, M. R., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00154 · Cited by 329
Ichii, H., Inverardi, L., Pileggi, A., Molano, R., Cabrera, O., Caicedo, A., Messinger, S., Kuroda, Y., Berggren, P., & Ricordi, C. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00913.x · Cited by 223
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210
Keymeulen, B., Gillard, P., Mathieu, C., Movahedi, B., Maleux, G. A., Delvaux, G., Ysebaert, D., Roep, B. O., Vandemeulebroucke, E., Marichal, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608141103 · Cited by 174
Ricordi, C., Goldstein, J., Balamurugan, A. N., Szot, G. L., Kin, T., Liu, C., Czarniecki, C. W., Barbaro, B., Bridges, N. D., Cano, J., et al. (2016) · Diabetes · doi:10.2337/db16-0234 · Cited by 200
“Postpurification islet recovery (total IEQ) was 582,370 (267,931) IEQ, representing 5,471 (2,709) IEQ/g trimmed pancreas.”
BackgroundInfluentialSelf-citationHuman Islet Oxygen Consumption Rate and DNA Measurements Predict Diabetes Reversal in Nude Mice
Papas, K., Colton, C., Nelson, R., Rozak, P. R., Avgoustiniatos, E., Scott, W., Wildey, G. M., Pisania, A., Weir, G., & Hering, B. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01655.x · Cited by 157
“In this study we examined the ability of 2 parameters characterizing human islet quality: (1) OCR, a measure of viable volume and (2) OCR/DNA, a measure of FV, to predict DR in nude mice.”
BackgroundMethodInfluentialState of the Art of Clinical Islet Transplantation and Novel Protocols of Immunosuppression
Shapiro, A. M. J. (2011) · Current Diabetes Reports · doi:10.1007/s11892-011-0217-8 · Cited by 153
Ryan, E. A., Paty, B. W., Senior, P. A., Lakey, J. R. T., Bigam, D. L., & Shapiro, A. M. J. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.343 · Cited by 168
Risk factors for islet loss during culture prior to transplantation
Kin, T., Senior, P. A., O’Gorman, D., Richer, B., Salam, A., & Shapiro, A. M. J. (2008) · Transplant International · doi:10.1111/j.1432-2277.2008.00719.x · Cited by 151
The Portal Immunosuppressive Storm: Relevance to Islet Transplantation?
Shapiro, A. M. J., Gallant, H. L., Hao, E., Lakey, J., Mccready, T., Rajotte, R., Yatscoff, R. W., & Kneteman, N. (2005) · Therapeutic Drug Monitoring · doi:10.1097/00007691-200502000-00008 · Cited by 144
Contreras, J., Eckstein, C., Smyth, C. A., Bilbao, G., Vilatoba, M., Ringland, S., Young, C., Thompson, J., Fernández, J. A., Griffin, J., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2804 · Cited by 138
Risks and side effects of islet transplantation
Ryan, E. A., Paty, B. W., Senior, P. A., & Shapiro, A. M. J. (2004) · Current Diabetes Reports · doi:10.1007/s11892-004-0083-8 · Cited by 137
Modular tissue engineering for the vascularization of subcutaneously transplanted pancreatic islets
Vlahos, A. E., Cober, N., & Sefton, M. V. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619216114 · Cited by 132
“P islet transplantation is a promising treatment for those living with type 1 diabetes (1, 2), but this therapy has limitations (3, 4).”
BackgroundShapiro, A. M. J. (2012) · The Review of Diabetic Studies · doi:10.1900/rds.2012.9.385 · Cited by 134
“[254]”
Magnetic Resonance-Defined Periportal Steatosis Following Intraportal Islet Transplantation
Markmann, J. F., Rosen, M. A., Siegelman, E. S., Soulen, M. C., Deng, S., Barker, C. F., & Naji, A. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1591 · Cited by 129
Self-citationBussiere, C. T., Lakey, J. R. T., Shapiro, A. M. J., & Korbutt, G. S. (2006) · Diabetologia · doi:10.1007/s00125-006-0374-5 · Cited by 116
“Similar decreases in insulin response to glucose have been reported in an allograft porcine model of islet transplantation and in the clinical setting of patients who receive islet transplantation [27, 38].”
BackgroundRescue Purification Maximizes the Use of Human Islet Preparations for Transplantation
Ichii, H., Pileggi, A., Molano, R., Baidal, D., Khan, A., Kuroda, Y., Inverardi, L., Goss, J. A., Alejandro, R., & Ricordi, C. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00698.x · Cited by 116
Shipment of Human Islets for Transplantation
Ichii, H., Sakuma, Y., Pileggi, A., Fraker, C. A., Álvarez, A., Montelongo, J., Szust, J., Khan, A., Inverardi, L., Naziruddin, B., et al. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01687.x · Cited by 113
β-Cell Function Following Human Islet Transplantation for Type 1 Diabetes
Rickels, M. R., Schutta, M. H., Markmann, J. F., Barker, C. F., Naji, A., & Teff, K. L. (2005) · Diabetes · doi:10.2337/diabetes.54.1.100 · Cited by 129
“tation at HUP has previously been reported (3).”
BackgroundSelf-citationRapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo
Tanemura, M., Ohmura, Y., Deguchi, T., MACHIDA, T., Tsukamoto, R., Wada, H., Kobayashi, S., Marubashi, S., Eguchi, H., Ito, T., et al. (2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03771.x · Cited by 111
“Rapamycin has deleterious effects on islet b cell based on the blockade of VEGF-mediated survival pathways and inhibition of b-cell proliferation and by induction of apoptosis (20,34,42).”
BackgroundHafiz, M. M., Faradji, R., Froud, T., Pileggi, A., Baidal, D., Cure, P., Ponte, G., Poggioli, R., Cornejo, A., Messinger, S., et al. (2005) · Transplantation · doi:10.1097/01.tp.0000187881.97068.77 · Cited by 111
Transplantation for Type I Diabetes
Frank, A. M., Deng, S., Huang, X., Velidedeoğlu, E., Bae, Y.-S., Liu, C., Abt, P. L., Stephenson, R., Mohiuddin, M. M., Thambi-Pillai, T., et al. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000140754.26575.2a · Cited by 106
“Since this landmark study, a number of other centers have confirmed the Edmonton results in small series of patients, including at least 2 that reported success with islets from single donors.(12,13) In the largest concerted effort to replicate the results of Edmonton, the National Institutes of Health–supported “Immu…”
ResultSelf-citationNew insights into the architecture of the islet of Langerhans: a focused cross-species assessment
Drigo, R. A. E., Ali, Y., Díez, J., Srinivasan, D. K., Berggren, P., & Boehm, B. O. (2015) · Diabetologia · doi:10.1007/s00125-015-3699-0 · Cited by 120
“dependency on exogenous insulin application as quickly as 20 days after islet transplantation [61], well before complete islet innervation is established.”
BackgroundRickels, M. R., Liu, C., Shlansky-Goldberg, R. D., Soleimanpour, S. A., Vivek, K., Kamoun, M., Min, Z., Markmann, E., Palangian, M., Dalton-Bakes, C., et al. (2013) · Diabetes · doi:10.2337/db12-1802 · Cited by 103
“Islets were isolated using a modified Ricordi method (13) with Liberase enzyme (Roche, Indianapolis, IN) (14) as previously described (15).”
MethodSelf-citationHilbrands, R., Huurman, V. A. L., Gillard, P., Velthuis, J. H. L., Waele, M. D., Mathieu, C., Kaufman, L., Pipeleers-Marichal, M. A., Ling, Z., Movahedi, B., et al. (2009) · Diabetes · doi:10.2337/db09-0160 · Cited by 102
“CD3+ count (cell/mm3) 24 (15-43) 36 (9-83) 0.”
BackgroundInfluentialPonte, G., Pileggi, A., Messinger, S., Alejandro, A., Ichii, H., Baidal, D. A., Khan, A., Ricordi, C., Goss, J. A., & Alejandro, R. (2007) · Cell Transplantation · doi:10.3727/000000007783465082 · Cited by 100
Chronic Pancreatitis: Recent Advances and Ongoing Challenges
Ahmad, S. A., Wray, C. J., Rilo, H., Choe, K. A., Gelrud, A., Howington, J. A., Lowry, A. M., & Matthews, J. B. (2006) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2005.12.005 · Cited by 89
Grattoni, A., Korbutt, G., Tomei, A. A., García, A. J., Pepper, A. R., Stabler, C., Brehm, M., Papas, K., Citro, A., Shirwan, H., et al. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01029-0 · Cited by 92
Cure, P., Pileggi, A., Froud, T., Messinger, S., Faradji, R. N., Baidal, D. A., Cardani, R., Curry, A., Poggioli, R., Pugliese, A., et al. (2008) · Transplantation · doi:10.1097/tp.0b013e318166a27b · Cited by 86
Islet Cell Hormonal Responses to Hypoglycemia After Human Islet Transplantation for Type 1 Diabetes
Rickels, M. R., Schutta, M. H., Mueller, R., Markmann, J. F., Barker, C. F., Naji, A., & Teff, K. L. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3205 · Cited by 92
“The procedure for islet transplantation at HUP has been previously reported (18).”
MethodSelf-citationSong, S., & Roy, S. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25895 · Cited by 103
“Islet transplantation requires infusion of high-quality islets isolated from a total of two to four donors to treat one recipient (Markmann et al., 2003).”
BackgroundIn Vivo Bioluminescence Imaging of Transplanted Islets and Early Detection of Graft Rejection
Chen, X., Zhang, X.-M., Larson, C., Baker, M., & Kaufman, D. (2006) · Transplantation · doi:10.1097/01.tp.0000206109.71181.bf · Cited by 85
Akashi, S., Sho, M., Kashizuka, H., Hamada, K., Ikeda, N., Kuzumoto, Y., Tsurui, Y., Nomi, T., Mizuno, T., Kanehiro, H., et al. (2005) · Transplantation · doi:10.1097/01.tp.0000166338.99933.e1 · Cited by 87
“Furthermore, recent advances in clinical islet cell transplantation have demonstrated an excellent outcome, improving the quality of life of patients (24,25).”
BackgroundTransduction of Human Islets with Pseudotyped Lentiviral Vectors
Kobinger, G., Deng, S., Louboutin, J., Vatamaniuk, M., Matschinsky, F., Markmann, J., Raper, S., & Wilson, J. M. (2004) · Human Gene Therapy · doi:10.1089/104303404772680010 · Cited by 84
Self-citationThe Effect of Pancreatic Islet Transplantation on Progression of Diabetic Retinopathy and Neuropathy
Lee, T. C., Barshes, N. R., O'Mahony, C. A., Nguyen, L. H., Brunicardi, F. C., Ricordi, C., Alejandro, R., Schock, A. P., Mote, A., & Goss, J. A. (2005) · Transplantation Proceedings · doi:10.1016/j.transproceed.2005.03.011 · Cited by 84
Expectations and Strategies Regarding Islet Transplantation: Metabolic Data From the GRAGIL 2 Trial
Badet, L., Benhamou, P., Wojtusciszyn, A., Baertschiger, R. M., Guittard, L., Kessler, L., Penfornis, A., Thivolet, C. H., Renard, É., Bosco, D., et al. (2007) · Transplantation · doi:10.1097/01.tp.0000268511.64428.d8 · Cited by 80
“Other groups have reported insulin independence with single donor transplantation (17, 18).”
BackgroundToso, C., Baertschiger, R. M., Morel, P., Bosco, D., Armanet, M., Wojtusciszyn, A., Badet, L., Philippé, J., Becker, C. D., Hadaya, K., et al. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01303.x · Cited by 80
“Both AUC and AIR remained stable afterwards, in accordance with other reports (3,8).”
ResultImproved Human Islet Isolation Using Nicotinamide
Ichii, H., Wang, X., Messinger, S., Alvarez, A., Fraker, C., Khan, A., Kuroda, Y., Inverardi, L., Goss, J. A., Alejandro, R., et al. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01452.x · Cited by 77
Contreras, J., Xie, D., Mays, J., Smyth, C. A., Eckstein, C., Rahemtulla, F., Young, C., Thompson, J., Bilbao, G., Curiel, D., et al. (2004) · Surgery · doi:10.1016/j.surg.2004.05.031 · Cited by 76
Allosensitization of Islet Allograft Recipients
Cardani, R., Pileggi, A., Ricordi, C., Gomez, C. I., Baidal, D. A., Ponte, G., Mineo, D., Faradji, R. N., Froud, T., Ciancio, G., et al. (2007) · Transplantation · doi:10.1097/01.tp.0000290388.70019.6e · Cited by 77
“By contrast, only 9.5% (4/42) of patients after 2000 displayed PRA by CDC while on immunosuppression (subjects 27, 29, 57, and 60; Table 2); only 7/42 subjects were IAK, with the majority being ITA (n 27) and I-BMT (n 8).”
BackgroundInfluentialAugsornworawat, P., Hogrebe, N. J., Ishahak, M., Schmidt, M. D., Marquez, E., Maestas, M. M., Veronese-Paniagua, D., Gale, S. E., Miller, J. R., Velazco-Cruz, L., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01150-8 · Cited by 91
A Significant Role for Histocompatibility in Human Islet Transplantation
Mohanakumar, T., Narayanan, K., Desai, N., Ramachandran, S., Shenoy, S., Jendrisak, M., Susskind, B., Olack, B., Benshoff, N., Phelan, D., et al. (2006) · Transplantation · doi:10.1097/01.tp.0000226161.82581.b2 · Cited by 70
“The general requirement for multiple islet infusions also remains a significant issue despite the recent reports of successful reversal of diabetes following single donor transplant (4, 9).”
BackgroundResultSelf-citationUnraveling the Secrets of Single Donor Success in Islet Transplantation
Shapiro, A. M. J., & Ricordi, C. (2004) · American Journal of Transplantation · doi:10.1046/j.1600-6143.2003.00375.x · Cited by 63
“Notable progress includes the introduction of the perfluorodecalin (PFC) ‘two-layer’ method for pancreas protection during transportation and rescue of marginal donors (21– 25), successful single-donor islet transplants from obese, nonheart-beating donors (26,27), and the routine use of islet culture rather than immed…”
BackgroundHogan, A. R. (2007) · Frontiers in bioscience · doi:10.2741/2755 · Cited by 68
“1194 transplantation (35, 36, 46), but generally requires sequential or pooled islet preparations obtained from two to three donor pancreata (28, 30, 35, 36, 47, 48).”
BackgroundReversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets.
Kin, T., Korbutt, G., Kobayashi, T., Dufour, J., & Rajotte, R. (2005) · Diabetes · doi:10.2337/diabetes.54.4.1032 · Cited by 65
Islet Isolation for Clinical Transplantation
Kin, T. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_30 · Cited by 74
“This protocol has set the standard worldwide for islet transplantation and now many other groups have attained similar success [3–5].”
BackgroundPancreatic islet transplantation: current advances and challenges
Wang, Q., Huang, Y., Liu, L., Zhao, X., Sun, Y., Mao, X., & Li, S.-W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1391504 · Cited by 63
“When islet transplant recipients reach the milestone of 5 years after their last islet cell infusion, approximately 95% of patients who meet these 4 common factors experience no SHEs and greatly bene fi t from improved glycemic control (13).”
BackgroundWeaver, J. D., Headen, D., Coronel, M. M., Hunckler, M. D., Shirwan, H., & García, A. J. (2018) · American Journal of Transplantation · doi:10.1111/ajt.15168 · Cited by 62
Pig islet xenograft rejection in a mouse model with an established human immune system
Tonomura, N., Shimizu, A., Wang, S.-M., Yamada, K., Tchipashvili, V., Weir, G., & Yang, Y. (2008) · Xenotransplantation · doi:10.1111/j.1399-3089.2008.00450.x · Cited by 62
Lee, D.-Y., Park, S. J., Lee, S., Nam, J., & Byun, Y. (2007) · Tissue engineering · doi:10.1089/ten.2006.0009 · Cited by 61
Song, S., Faleo, G., Yeung, R., Kant, R., Posselt, A. M., Desai, T. A., Tang, Q., & Roy, S. (2016) · Scientific Reports · doi:10.1038/srep23679 · Cited by 59
Paty, B. W., Senior, P. A., Lakey, J. R. T., Shapiro, A. M. J., & Ryan, E. A. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.165 · Cited by 58
Rickels, M. R., Schutta, M. H., Mueller, R., Kapoor, S. C., Markmann, J. F., Naji, A., & Teff, K. L. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2426 · Cited by 59
Self-citationBeta-Cell Replacement for Type I Diabetes
Stock, P. G., & Bluestone, J. A. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.103539 · Cited by 48
“Transplant groups from the University of Minnesota (34, 48) and University of Pennsylvania (49) have demonstrated consistent ability to achieve insulin independence from a single donor.”
BackgroundInfluentialIslet Transplantation: Progress and Challenge
Gaglia, J. L., Shapiro, A. M. J., & Weir, G. C. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.03.014 · Cited by 49
Linning, K. D., Tai, M.-H., Madhukar, B. V., Chang, C., Reed, D. N., Ferber, S., Trosko, J. E., & Olson, L. K. (2004) · Pancreas · doi:10.1097/00006676-200410000-00015 · Cited by 47
Cross, S. E., Richards, S. K., Clark, A., Benest, A. V., Bates, D. O., Mathieson, P. W., Johnson, P., Harper, S. J., & Smith, R. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0670-8 · Cited by 55
“Successful pancreatic islet transplantation achieves significantly better glycaemic control than is achieved with bolus insulin injections, with almost complete resolution of hypoglycaemia even with partial graft function [1–4].”
BackgroundIslet Size Index as a Predictor of Outcomes in Clinical Islet Autotransplantation
Suszynski, T. M., Wilhelm, J. J., Radosevich, D. M., Balamurugan, A. N., Sutherland, D. E. R., Beilman, G. J., Dunn, T. B., Chinnakotla, S., Pruett, T. L., Vickers, S. M., et al. (2014) · Transplantation · doi:10.1097/01.tp.0000441873.35383.1e · Cited by 54
Current status of islet cell transplantation
Ichii, H., & Ricordi, C. (2008) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-008-0021-2 · Cited by 102
“While selected centers have reported high rates of success [4, 6, 32, 33, 48, 56, 57, 78, 83], islet graft failures in the very early post-transplant period have been reported.”
InfluentialAllogeneic islet transplantation
Marzorati, S., Pileggi, A., & Ricordi, C. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.7.11.1627 · Cited by 46
“Expert opinion The success rate of allogeneic islet transplantation for the treatment of patients with T1DM has steadily improved over the years.”
BackgroundMethodInfluentialHilling, D., Bouwman, E., Terpstra, O., & de Mheen, P. J. M.-V. (2014) · Cell Transplantation · doi:10.3727/096368913x666412 · Cited by 46
“However, successful islet isolations from DCD donors have also been reported previously (43,46,50,83).”
BackgroundRickels, M. R., Naji, A., & Teff, K. L. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2519 · Cited by 45
Self-citationMita, A., Ricordi, C., Messinger, S., Miki, A., Misawa, R., Barker, S., Molano, R. D., Haertter, R., Khan, A., Miyagawa, S., et al. (2010) · Cell Transplantation · doi:10.3727/096368910x516600 · Cited by 47
“Further study will be needed to deusing islets generally obtained from multiple donors (16,29,45,46).”
BackgroundRickels, M. R., Kamoun, M., Kearns, J. D., Markmann, J. F., & Naji, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0172 · Cited by 39
Self-citationConsiderations and challenges of islet transplantation and future therapies on the horizon
Walker, S. L. M., Appari, M., & Forbes, S. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00310.2021 · Cited by 47
“0001), 90 minute C-peptide concentrations following a mixed meal tolerance test at 1 114 year post first transplant, were not significantly different [80].”
BackgroundOvercoming the Challenges Now Limiting Islet Transplantation
Pileggi, A., Cobianchi, L., Inverardi, L., & Ricordi, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1375.059 · Cited by 58
Health-Related Quality of Life after Pancreatic Islet Transplantation: A Longitudinal Study
Barshes, N. R., Vanatta, J. M., Mote, A., Lee, T. C., Schock, A. P., Balkrishnan, R., Brunicardi, F. C., & Goss, J. A. (2005) · Transplantation · doi:10.1097/01.tp.0000160816.21799.f5 · Cited by 41
Effect of Micro- and Macroencapsulation on Oxygen Consumption by Pancreatic Islets
Cornolti, R., Figliuzzi, M., & Remuzzi, A. (2009) · Cell Transplantation · doi:10.3727/096368909788341252 · Cited by 40
Characterization of pancreatic ductal cells in human islet preparations
Ichii, H., Miki, A., Yamamoto, T., Molano, R. D., Barker, S., Mita, A., Rodriguez‐Diaz, R., Klein, D., Pastori, R. L., Alejandro, R., et al. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.87 · Cited by 38
Jimenez‐Vera, E., Davies, S., Phillips, P. M., O’Connell, P. J., & Hawthorne, W. J. (2015) · Xenotransplantation · doi:10.1111/xen.12151 · Cited by 40
Immobilization of soluble complement receptor 1 on islets.
Nguyen, L. M., Teramura, Y., & Iwata, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.017 · Cited by 39
Bosco, M. D., Mohanasundaram, D., Drogemuller, C., Lang, C. J., Zalewski, P. D., & Coates, P. T. (2010) · The Review of Diabetic Studies · doi:10.1900/rds.2010.7.263 · Cited by 34
“In this therapy, cadaveric human donor pancreata are enzymatically digested to create islets for infusion into the T1D recipient’s liver under immunosuppressive drug regimen [1-3].”
MethodRickels, M. R., Naji, A., & Teff, K. L. (2007) · Transplantation · doi:10.1097/01.tp.0000287595.16442.a7 · Cited by 40
Self-citationEckhoff, D., Eckstein, C., Smyth, C. A., Vilatoba, M., Bilbao, G., Rahemtulla, F., Young, C., Thompson, J. A., Chaudry, I., & Contreras, J. (2004) · Surgery · doi:10.1016/j.surg.2004.05.009 · Cited by 37
Oxygenation of the Intraportally Transplanted Pancreatic Islet
Suszynski, T. M., Avgoustiniatos, E. S., & Papas, K. K. (2016) · Journal of Diabetes Research · doi:10.1155/2016/7625947 · Cited by 40
Overcoming barriers in clinical islet transplantation: Current limitations and future prospects
Chhabra, P., Sutherland, D. E. R., & Brayman, K. L. (2013) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2013.10.002 · Cited by 40
Self-citationGillard, P., Ling, Z., Mathieu, C., Crenier, L., Lannoo, M., Maes, B., Roep, B. O., Gorus, F., PIPELEERS, D. G., & Keymeulen, B. (2008) · Transplantation · doi:10.1097/tp.0b013e31815e8926 · Cited by 39
Small intestinal submucosa improves islet survival and function in vitro culture.
Xiaohui, T., Xue, W.-J., Xiaoming, D., Xinlu, P., Yan, T., Pux-un, T., & Xinshun, F. (2006) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.02.134 · Cited by 32
Omental Roll-Up: A Technique for Islet Engraftment in a Large Animal Model
Hefty, T. R., Kuhr, C. S., Chong, K. T., Guinee, D. G., Wang, W., Reems, J. A., & Greenbaum, C. J. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.11.842 · Cited by 29
Islet Alone Versus Islet After Kidney Transplantation: Metabolic Outcomes and Islet Graft Survival
Deng, S., Markmann, J. F., Rickels, M. R., Yeh, H., Kim, J. I., Lian, M., Gu, Y., Markmann, E., Palanjian, M., Barker, C. F., et al. (2009) · Transplantation · doi:10.1097/tp.0b013e3181b4bdbb · Cited by 28
Self-citationEvgenov, N. V., Pratt, J., Pantazopoulos, P., & Moore, A. V. (2008) · Transplantation · doi:10.1097/tp.0b013e31816b183e · Cited by 29
“Overall, the low impact of contaminating tissue on the in vivo MR imaging of islet transplantation is evident from (1) the low level of iron uptake by low-purity islet preparation, (2) longer T2 relaxation times of labeled nonendocrine tissue and/or of labeled low-purity islets in vitro, (3) the high rate of cell deat…”
ResultChoong, F. J., Freeman, C. G., Parish, C. R., & Simeonovic, C. J. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13366 · Cited by 31
One Hundred Human Pancreatic Islet Isolations at Baylor Research Institute
Takita, M., Matsumoto, S., Noguchi, H., Shimoda, M., Chujo, D., Sugimoto, K., Itoh, T., Lamont, J. P., Lara, L. F., Onaca, N. N., et al. (2010) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2010.11928648 · Cited by 28
“Markmann et al indicated that approximately 100 human islet isolations were necessary before initiating clinical islet transplantation (32).”
BackgroundDetection of Microbial Contamination during Human Islet Isolation
Kin, T., Rosichuk, S., Shapiro, A. M. J., & Lakey, J. (2007) · Cell Transplantation · doi:10.3727/000000007783464498 · Cited by 26
Small intestinal submucosa improves islet survival and function during in vitro culture.
Tian, X.-H., Xue, W., Ding, X.-M., Pang, X.-L., Teng, Y., Tian, P., & Feng, X.-S. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i46.7378 · Cited by 26
The effect of hypoxia on free and encapsulated adult porcine islets-an in vitro study
Muthyala, S., Safley, S., Gordan, K., Barber, G., Weber, C., & Sambanis, A. (2016) · Xenotransplantation · doi:10.1111/xen.12275 · Cited by 25
“Islet transplantation has proven to be a viable option for the treatment of people with Type 1 diabetes (1, 2) but the shortage of human cadaveric pancreata and deleterious consequences of long-term immunosuppression limit the of number of patients that can be treated to a small fraction of the…”
Effect of nicotinamide on early graft failure following intraportal islet transplantation
Jung, D., Park, J., Joo, S., Joh, J., Kwon, C., Kwon, G., & Kim, S.-J. (2009) · Experimental and Molecular Medicine · doi:10.3858/emm.2009.41.11.084 · Cited by 25
Anti-Proinflammatory Effects of Sirolimus on Human Islet Preparations
Mita, A., Ricordi, C., Miki, A., Barker, S., Haertter, R., Hashikura, Y., Miyagawa, S.-I., Burke, G. W., Inverardi, L., & Ichii, H. (2008) · Transplantation · doi:10.1097/tp.0b013e31817c79c0 · Cited by 22
Sutherland, D., Gruessner, R., Kandswamy, R., Humar, A., Hering, B., & Gruessner, A. (2004) · Transplantation Proceedings · doi:10.1016/s0889-8529(03)00099-9 · Cited by 23
“The unprecedented findings in recent islet transplant trials, first reported by Shapiro et al [39] and subsequently confirmed at additional institutions [44–46], marked a turning point in the history of islet transplantation, yet most patients required islets prepared from two or more donor pancreases.”
ResultNeonatal Sepsis in the Very Low Birth Weight Preterm Infants: Part 1: Review of Patho-physiology
Haque, K. N. (2010) · doi:10.2174/1996327001003010001 · Cited by 13
The Spleen Is an Ideal Site for Inducing Transplanted Islet Graft Expansion in Mice
Itoh, T., Nishinakamura, H., Kumano, K., Takahashi, H., & Kodama, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170899 · Cited by 22
Resolution of Severe Atopic Dermatitis after Tacrolimus Withdrawal
Ponte, G., Baidal, D. A., Romanelli, P., Faradji, R. N., Poggioli, R., Cure, P., Froud, T., Selvaggi, G., Pileggi, A., Ricordi, C., et al. (2007) · Cell Transplantation · doi:10.3727/000000007783464524 · Cited by 23
Islet transplantation: steady progress and current challenges
Pileggi, A., Alejandro, R., & Ricordi, C. (2006) · Current Opinion in Organ Transplantation · doi:10.1097/01.mot.0000203878.00901.26 · Cited by 20
Comparison of Whole Organ Pancreas and Isolated Islet Transplantation for Type 1 Diabetes
Frank, A. M., Barker, C. F., & Markmann, J. F. (2005) · Advances in Surgery · doi:10.1016/j.yasu.2005.04.010 · Cited by 23
Self-citation
Metadata
- Authors
- Markmann, J. F., Deng, S., Huang, X., Desai, N. M., Velidedeoglu, E. H., Lui, C., Frank, A., Markmann, E., Palanjian, M., Brayman, K., Wolf, B., Bell, E., Vitamaniuk, M., Doliba, N., Matschinsky, F., Barker, C. F., & Naji, A.
- Affiliations
- Hospital of the University of Pennsylvania (US)
- University of Pennsylvania (US)
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania Health System (US)
- Corresponding author
- Markmann, James F.
- Deng, Shaoping
- Huang, Xiaolun
- Desai, Niraj M.
- Lui, Chengyang
- Frank, Adam
- Markmann, Eileen
- Palanjian, Maral
- Brayman, Kenneth
- Barker, Clyde F.
- Naji, Ali
- ORCID
- Venue
- Annals of Surgery
- Published
- 2003-06
- Volume
- 237
- Issue
- 6
- Pages
- 741-750
- ISSN
- 0003-4932 (ISSN-L)
- PMC
- PMC1514687
- OpenAlex
- W2324941813
- Cited by
- 175
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 7 · 2012: 5
- FWCI
- 19.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Surgery (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pennsylvania
- National Center for Research Resources (M01-RR-00040, 1U42 RR 16600, M01RR000040, U42RR016600)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- islet transplantation, insulin independence, type 1 diabetes, hypoglycemia, hypoglycemia unawareness, graft function, islet mass
- MeSH terms
- Adult, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 1, Humans, Immunosuppressive Agents, Islets of Langerhans Transplantation, Recovery of Function
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