The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Clinical Utility of Bile Acid Sequestrants in the Treatment of Dyslipidemia: A Scientific Review
Abstract
Bile acid sequestrants (BAS) continue to command a position in the treatment of dyslipidemias 25 years after their introduction. Partial diversion of the enterohepatic circulation using BAS depletes the endogenous bile acid pool by approximately 40%, thus stimulating an increase in bile acid synthesis from cholesterol, which lowers low-density lipoprotein cholesterol (LDL-C) by 15 to 26%. Three BAS are currently used for treating hypercholesterolemia in the United States: the conventional sequestrants, cholestyramine and colestipol, and the specifically engineered BAS, colesevelam hydrochloride (HCl). Compared with conventional BAS, colesevelam HCl has enhanced specificity, greater affinity, and higher capacity for binding bile acids, due to its polymer structure engineered for bile acid sequestration. BAS are not absorbed by the intestine and thus have no systemic drug-drug interactions, but may interfere with the absorption of some drugs. Although BAS monotherapy effectively lowers LDL-C, combination therapy, especially with BAS and statins, is becoming increasingly common due to complementary mechanisms of action. Low-dose statin plus BAS combinations lead to greater or similar LDL-C reductions compared with high-dose statin monotherapy and may have a better safety profile. Combinations of BAS with nonstatin lipid-lowering agents, including niacin, fibrates, and cholesterol absorption inhibitors, may be useful in those patients who require intensive lipid-lowering, but are statin intolerant. BAS treatment can significantly reduce coronary artery disease (CAD) progression and the risk of CAD-associated outcomes. It is also becoming clear that BAS and other therapies that manipulate the bile acid synthetic pathway may have clinically useful therapeutic effects on other metabolic disorders including type 2 diabetes.
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Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
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Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
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ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins
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“Small, dense LDL particles are emerging as a risk factor for CAD,(63) and colestipol has been shown to reduce LDL particle size, creating more atherogenic particles.(64) Therefore, the effect of colesevelam HCl on LDL particle size was examined.”
BackgroundWalldius, G., Erikson, U., Olsson, A. G., Bergstrand, L., Hådell, K., Johansson, J., Kaijser, L., Lassvik, C., Mölgaard, J., Nilsson, S., et al. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90579-7 · Cited by 248
(1992) · Archives of Internal Medicine · doi:10.1001/archinte.1992.00400190041009 · Cited by 58
Cited by
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., & Staels, B. (2009) · Physiological Reviews · doi:10.1152/physrev.00010.2008 · Cited by 1,678
Jellinger, P. S., Handelsman, Y., Rosenblit, P. D., Bloomgarden, Z. T., Fonseca, V. A., Garber, A. J., Grunberger, G., Guerin, C. K., Bell, D. S. H., Mechanick, J. I., et al. (2017) · Endocrine Practice · doi:10.4158/ep171764.appgl · Cited by 1,094
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z.-Z., Takahashi, S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76738 · Cited by 693
Narrative review: statin-related myopathy
Joy, T. R., & Hegele, R. A. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-12-200906160-00009 · Cited by 453
Cowpea: an overview on its nutritional facts and health benefits
Jayathilake, C., Visvanathan, R., Deen, A., Bangamuwage, R., Jayawardana, B. C., Nammi, S., & Liyanage, R. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9074 · Cited by 336
Metadata
- Authors
- Insull, W.
- Venue
- Southern Medical Journal
- Publisher
- Southern Medical Association
- Published
- 2006-03
- Volume
- 99
- Issue
- 3
- Pages
- 257-273
- ISSN
- 0038-4348 (ISSN-L)
- OpenAlex
- W1541662874
- Cited by
- 308
- References
- 10
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- closed
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