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Conversion to sirolimus: a successful treatment for posttransplantation Kaposi???s sarcoma12
Abstract
The increased incidence of Kaposi's sarcoma (KS) in organ transplantation has been related to the KS herpesvirus and the permissive effect of immunosuppressive therapy. Calcineurin inhibitors are the cornerstone of immunosuppression in organ transplantation, although they could promote tumor progression. In contrast, sirolimus, a new immunosuppressive agent, exhibits potent antitumor activity. We postulated that conversion from cyclosporine to sirolimus in patients with KS could favor regression of KS lesions without increasing the risk of graft rejection. Two renal transplant recipients with KS underwent conversion from cyclosporine to sirolimus. Both patients showed complete regression of KS lesions and excellent clinical and functional results. Sirolimus offers a new and promising approach to the management of posttransplantation KS and probably to other types of malignancies in organ transplant recipients.
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Cited by
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Sabatini, D. M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1974 · Cited by 1,322
Sirolimus for Kaposi's Sarcoma in Renal-Transplant Recipients
Stallone, G., Schena, A., Infante, B., Di Paolo, S., Loverre, A., Maggio, G., Ranieri, E., Gesualdo, L., Schena, F. P., & Grandaliano, G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042831 · Cited by 990
Immunosuppressive Drugs and the Risk of Cancer after Organ Transplantation
Dantal, J., & Soulillou, J.-P. (2005) · New England Journal of Medicine · doi:10.1056/nejme058018 · Cited by 256
Leidal, A. M., Cyr, D. P., Hill, R. J., Lee, P. W. K., & McCormick, C. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.005 · Cited by 113
Metadata
- Authors
- Campistol, J. M., Gutierrez-Dalmau, A., & Torregrosa, J. V.
- Venue
- Transplantation
- Published
- 2004-03
- Volume
- 77
- Issue
- 5
- Pages
- 760-762
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W1989270320
- Cited by
- 261
- References
- 0
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Campistol, J. M., Gutierrez-Dalmau, A., & Torregrosa, J. V. (2004). Conversion to sirolimus: a successful treatment for posttransplantation Kaposi???s sarcoma12. Transplantation. https://doi.org/10.1097/01.tp.0000115344.18025.0b
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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