Defining the role of mTOR in cancer

Guertin, David A.; Sabatini, David M.

doi:10.1016/j.ccr.2007.05.008

Cited by 2,833PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerAutophagy in Disease and Therapy

Defining the role of mTOR in cancer

Open access

Guertin, David A., Sabatini, David M.·2007·Cancer Cell

DOI 10.1016/j.ccr.2007.05.008

Open this paper in CoChat — free account Open PDF

Abstract

The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell-signaling pathways commonly deregulated in human cancers. This has led to the prediction that mTOR inhibitors may be useful in oncology, and derivatives of one such molecule, rapamycin (from which mTOR derives its name), are currently in clinical development. In this review, we discuss recent progress in understanding mTOR signaling, paying particular attention to its relevance in cancer. We further discuss the use of rapamycin in oncology and conclude with a discussion on the future of mTOR-targeted therapy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.ccr.2007.05.008

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

mTORC1 is an important regulator of cell proliferation and metabolism.
“This pathway is an important regulator of cell proliferation and metabolism (Hay and Sonenberg, 2004; Guertin and Sabatini, 2007).”
From Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR (2023) · cites this paper as Guertin and Sabatini, 2007

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Part of this paper’s reference list could not be split into single entries.

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216 · see citing works
Self-citation
Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control
Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886 · see citing works
The Tuberous Sclerosis Complex
Crino, P. B., Nathanson, K. L., & Henske, E. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmra055323 · Cited by 1,793 · see citing works
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562 · see citing works
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Sancak, Y., Thoreen, C. C., Peterson, T. R., Lindquist, R. A., Kang, S. A., Spooner, E., Carr, S. A., & Sabatini, D. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.003 · Cited by 1,236 · see citing works
Self-citation
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
Majumder, P. K., Febbo, P. G., Bikoff, R., Berger, R., Xue, Q., McMahon, L. M., Manola, J., Brugarolas, J., McDonnell, T. J., Golub, T. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1052 · Cited by 964 · see citing works
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Samuels, Y., Diaz, L. A., Schmidt-Kittler, O., Cummins, J. M., DeLong, L., Cheong, I., Rago, C., Huso, D. L., Lengauer, C., Kinzler, K. W., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.014 · Cited by 915 · see citing works
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
Thomas, G. V., Tran, C., Mellinghoff, I. K., Welsbie, D. S., Chan, E., Fueger, B., Czernin, J., & Sawyers, C. L. (2006) · Nature Medicine · doi:10.1038/nm1337 · Cited by 604 · see citing works
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
Tavazoie, S. F., Alvarez, V. A., Ridenour, D. A., Kwiatkowski, D. J., & Sabatini, B. L. (2005) · Nature Neuroscience · doi:10.1038/nn1566 · Cited by 497 · see citing works
Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth
Yang, Z.-Z., Tschopp, O., Hemmings-Mieszczak, M., Feng, J., Brodbeck, D., Perentes, E., & Hemmings, B. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302847200 · Cited by 384 · see citing works

Flagged first, then by citations

Research works printed but not linked: 127

[1]1. Ackah, E. ∙ Yu, J. ∙ Zoellner, S. ... Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis J. Clin. Invest. 2005; 115:2119-2127 Crossref Scopus (191) PubMed Google Scholar
[2]2. Alessi, D.R. ∙ Andjelkovic, M. ∙ Caudwell, B. ... Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 1996; 15:6541-6551 Crossref PubMed Google Scholar
[3]3. Ali, S.M. ∙ Sabatini, D.M. Structure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site J. Biol. Chem. 2005; 280:19445-19448 Crossref Scopus (85) PubMed Google Scholar
[4]4. Baba, M. ∙ Hong, S.B. ∙ Sharma, N. ... Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling Proc. Natl. Acad. Sci. USA. 2006; 103:15552-15557 Crossref Scopus (152) PubMed Google Scholar
[5]5. Bachmann, R.A. ∙ Kim, J.H. ∙ Wu, A.L. ... A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1 J. Biol. Chem. 2006; 281:7357-7363 Crossref Scopus (48) PubMed Google Scholar
[6]6. Ballif, B.A. ∙ Roux, P.P. ∙ Gerber, S.A. ... Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors Proc. Natl. Acad. Sci. USA. 2005; 102:667-672 Crossref Scopus (132) Google Scholar
[7]7. Bernardi, R. ∙ Guernah, I. ∙ Jin, D. ... PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR Nature. 2006; 442:779-785 Crossref Scopus (177) PubMed Google Scholar
[8]8. Biondi, R.M. ∙ Kieloch, A. ∙ Currie, R.A. ... The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB EMBO J. 2001; 20:4380-4390 Crossref Scopus (214) PubMed Google Scholar
[9]9. Brognard, J. ∙ Sierecki, E. ∙ Gao, T. ... PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms Mol. Cell. 2007; 25:917-931 Full Text Full Text (PDF) Scopus (198) PubMed Google Scholar
[10]10. Buerger, C. ∙ DeVries, B. ∙ Stambolic, V. Localization of Rheb to the endomembrane is critical for its signaling function Biochem. Biophys. Res. Commun. 2006; 344:869-880 Crossref Scopus (60) PubMed Google Scholar
[11]11. Campistol, J.M. ∙ Gutierrez-Dalmau, A. ∙ Torregrosa, J.V. Conversion to sirolimus: a successful treatment for posttransplantation Kaposi's sarcoma Transplantation. 2004; 77:760-762 Crossref Scopus (166) PubMed Google Scholar
[12]12. Chen, M.L. ∙ Xu, P.Z. ∙ Peng, X.D. ... The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/− mice Genes Dev. 2006; 20:1569-1574 Crossref Scopus (149) PubMed Google Scholar
[13]13. Chiang, G.G. ∙ Abraham, R.T. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase J. Biol. Chem. 2005; 280:25485-25490 Crossref Scopus (183) PubMed Google Scholar
[14]14. Choi, J.H. ∙ Bertram, P.G. ∙ Drenan, R. ... The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase EMBO Rep. 2002; 3:988-994 Crossref Scopus (61) Google Scholar
[15]15. Collins, B.J. ∙ Deak, M. ∙ Arthur, J.S. ... In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation EMBO J. 2003; 22:4202-4211 Crossref Scopus (119) PubMed Google Scholar
[16]16. Corradetti, M.N. ∙ Inoki, K. ∙ Bardeesy, N. ... Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome Genes Dev. 2004; 18:1533-1538 Crossref Scopus (307) PubMed Google Scholar
[18]18. Desai, B.N. ∙ Myers, B.R. ∙ Schreiber, S.L. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction Proc. Natl. Acad. Sci. USA. 2002; 99:4319-4324 Crossref Scopus (137) PubMed Google Scholar
[19]19. Di Cristofano, A. ∙ Pesce, B. ∙ Cordon-Cardo, C. ... Pten is essential for embryonic development and tumour suppression Nat. Genet. 1998; 19:348-355 Crossref Scopus (883) PubMed Google Scholar
[20]20. Dong, J. ∙ Pan, D. Tsc2 is not a critical target of Akt during normal Drosophila development Genes Dev. 2004; 18:2479-2484 Crossref Scopus (72) Google Scholar
[21]21. Dorrello, N.V. ∙ Peschiaroli, A. ∙ Guardavaccaro, D. ... S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth Science. 2006; 314:467-471 Crossref Scopus (260) PubMed Google Scholar
[22]22. Drenan, R.M. ∙ Liu, X. ∙ Bertram, P.G. ... FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus J. Biol. Chem. 2004; 279:772-778 Crossref Scopus (96) PubMed Google Scholar
[23]23. Easton, J.B. ∙ Houghton, P.J. mTOR and cancer therapy Oncogene. 2006; 25:6436-6446 Crossref Scopus (277) PubMed Google Scholar
[24]24. Eng, C. PTEN: one gene, many syndromes Hum. Mutat. 2003; 22:183-198 Crossref Scopus (419) PubMed Google Scholar
[25]25. Faivre, S. ∙ Kroemer, G. ∙ Raymond, E. Current development of mTOR inhibitors as anticancer agents Nat. Rev. Drug Discov. 2006; 5:671-688 Crossref Scopus (461) PubMed Google Scholar
[26]26. Fan, Q.W. ∙ Weiss, W.A. Isoform specific inhibitors of PI3 kinase in glioma Cell Cycle. 2006; 5:2301-2305 Crossref Google Scholar
[27]27. Findlay, G.M. ∙ Yan, L. ∙ Procter, J. ... A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling Biochem. J. 2007; 430:13-20 Google Scholar
[28]28. Franz, D.N. ∙ Leonard, J. ∙ Tudor, C. ... Rapamycin causes regression of astrocytomas in tuberous sclerosis complex Ann. Neurol. 2006; 59:490-498 Crossref Scopus (288) PubMed Google Scholar
[29]29. Frias, M.A. ∙ Thoreen, C.C. ∙ Jaffe, J.D. ... mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s Curr. Biol. 2006; 16:1865-1870 Full Text Full Text (PDF) Scopus (247) PubMed Google Scholar
[30]30. Fumarola, C. ∙ La Monica, S. ∙ Alfieri, R.R. ... Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis Cell Death Differ. 2005; 12:1344-1357 Crossref Scopus (39) Google Scholar
[31]31. Furuyama, T. ∙ Kitayama, K. ∙ Shimoda, Y. ... Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice J. Biol. Chem. 2004; 279:34741-34749 Crossref Scopus (157) PubMed Google Scholar
[32]32. Gangloff, Y.G. ∙ Mueller, M. ∙ Dann, S.G. ... Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development Mol. Cell. Biol. 2004; 24:9508-9516 Crossref Scopus (201) PubMed Google Scholar
[33]33. Gao, T. ∙ Furnari, F. ∙ Newton, A.C. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth Mol. Cell. 2005; 18:13-24 Full Text Full Text (PDF) Scopus (351) PubMed Google Scholar
[34]34. Ghosh, S. ∙ Tergaonkar, V. ∙ Rothlin, C.V. ... Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival Cancer Cell. 2006; 10:215-226 Full Text Full Text (PDF) Scopus (55) PubMed Google Scholar
[35]35. Granville, C.A. ∙ Memmott, R.M. ∙ Gills, J.J. ... Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway Clin. Cancer Res. 2006; 12:679-689 Crossref Scopus (129) PubMed Google Scholar
[36]36. Granville, C.A. ∙ Warfel, N. ∙ Tsurutani, J. ... Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen-Induced Murine Lung Tumors Clin. Cancer Res. 2007; 13:2281-2289 Crossref Scopus (53) PubMed Google Scholar
[37]37. Greer, E.L. ∙ Brunet, A. FOXO transcription factors at the interface between longevity and tumor suppression Oncogene. 2005; 24:7410-7425 Crossref Scopus (515) PubMed Google Scholar
[38]38. Guba, M. ∙ von Breitenbuch, P. ∙ Steinbauer, M. ... Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor Nat. Med. 2002; 8:128-135 Crossref Scopus (1062) PubMed Google Scholar
[39]39. Guertin, D.A. ∙ Guntur, K.V. ∙ Bell, G.W. ... Functional genomics identifies TOR-regulated genes that control growth and division Curr. Biol. 2006; 16:958-970 Full Text Full Text (PDF) Scopus (77) Google Scholar
[40]40. Guertin, D.A. ∙ Sabatini, D.M. An expanding role for mTOR in cancer Trends Mol. Med. 2005; 11:353-361 Full Text Full Text (PDF) Scopus (293) PubMed Google Scholar
[41]41. Guertin, D.A. ∙ Stevens, D.M. ∙ Thoreen, C.C. ... Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCalpha, but Not S6K1 Dev. Cell. 2006; 11:859-871 Full Text Full Text (PDF) Scopus (489) PubMed Google Scholar
[42]42. Haar, E.V. ∙ Lee, S.I. ∙ Bandhakavi, S. ... Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 Nat. Cell Biol. 2007; 9:316-323 Crossref Scopus (413) Google Scholar
[43]43. Hanada, M. ∙ Feng, J. ∙ Hemmings, B.A. Structure, regulation and function of PKB/AKT–a major therapeutic target Biochim. Biophys. Acta. 2004; 1697:3-16 Crossref Scopus (377) PubMed Google Scholar
[44]44. Hara, K. ∙ Maruki, Y. ∙ Long, X. ... Raptor, a binding partner of target of rapamycin (TOR) mediates TOR Action Cell. 2002; 110:177-189 Full Text Full Text (PDF) Scopus (760) PubMed Google Scholar
[45]45. Hartmann, C. ∙ Johnk, L. ∙ Kitange, G. ... Transcript map of the 3.7-Mb D19S112–D19S246 candidate tumor suppressor region on the long arm of chromosome 19 Cancer Res. 2002; 62:4100-4108 PubMed Google Scholar
[46]46. Hietakangas, V. ∙ Cohen, S.M. Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth Genes Dev. 2007; 21:632-637 Crossref Scopus (60) PubMed Google Scholar
[47]47. Hipp, S. ∙ Ringshausen, I. ∙ Oelsner, M. ... Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells Haematologica. 2005; 90:1433-1434 PubMed Google Scholar
[48]48. Holz, M.K. ∙ Ballif, B.A. ∙ Gygi, S.P. ... mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events Cell. 2005; 123:569-580 Full Text Full Text (PDF) Scopus (389) PubMed Google Scholar
[49]49. Holz, M.K. ∙ Blenis, J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase J. Biol. Chem. 2005; 280:26089-26093 Crossref Scopus (166) PubMed Google Scholar
[50]50. Hosaka, T. ∙ Biggs, III, W.H. ∙ Tieu, D. ... Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification Proc. Natl. Acad. Sci. USA. 2004; 101:2975-2980 Crossref Scopus (307) PubMed Google Scholar
[51]51. Hresko, R.C. ∙ Mueckler, M. mTOR/RICTOR is the Ser473 kinase for Akt/PKB in 3T3–L1 adipocytes J. Biol. Chem. 2005; 280:40406-40416 Crossref Scopus (321) PubMed Google Scholar
[52]52. Hsu, Y.C. ∙ Chern, J.J. ∙ Cai, Y. ... Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase Nature. 2007; 445:785-788 Crossref Scopus (142) PubMed Google Scholar
[53]53. Huang, B. ∙ Porter, G. Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis Acta Pharmacol. Sin. 2005; 26:1253-1258 Crossref Scopus (28) Google Scholar
[54]54. Hudson, C.C. ∙ Liu, M. ∙ Chiang, G.G. ... Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin Mol. Cell. Biol. 2002; 22:7004-7014 Crossref Scopus (622) PubMed Google Scholar
[55]55. Huffman, T.A. ∙ Mothe-Satney, I. ∙ Lawrence, Jr., J.C. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin Proc. Natl. Acad. Sci. USA. 2002; 99:1047-1052 Crossref Scopus (120) Google Scholar
[56]56. Inoki, K. ∙ Li, Y. ∙ Zhu, T. ... TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat. Cell Biol. 2002; 12:12 Google Scholar
[57]57. Inoki, K. ∙ Ouyang, H. ∙ Zhu, T. ... TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth Cell. 2006; 126:955-968 Full Text Full Text (PDF) Scopus (385) PubMed Google Scholar
[58]58. Inoki, K. ∙ Zhu, T. ∙ Guan, K.L. TSC2 mediates cellular energy response to control cell growth and survival Cell. 2003; 115:577-590 Full Text Full Text (PDF) Scopus (1316) PubMed Google Scholar
[59]59. Jacinto, E. ∙ Facchinetti, V. ∙ Liu, D. ... SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity Cell. 2006; 127:125-137 Full Text Full Text (PDF) Scopus (528) PubMed Google Scholar
[60]60. Jacinto, E. ∙ Loewith, R. ∙ Schmidt, A. ... Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive Nat. Cell Biol. 2004; 6:1122-1128 Crossref Scopus (754) PubMed Google Scholar
[61]61. Jaeschke, A. ∙ Hartkamp, J. ∙ Saitoh, M. ... Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent J. Cell Biol. 2002; 159:217-224 Crossref Scopus (148) PubMed Google Scholar
[62]62. Johannessen, C.M. ∙ Reczek, E.E. ∙ James, M.F. ... The NF1 tumor suppressor critically regulates TSC2 and mTOR Proc. Natl. Acad. Sci. USA. 2005; 102:8573-8578 Crossref Scopus (238) PubMed Google Scholar
[63]63. Kim, D.-H. ∙ Sarbassov, D.D. ∙ Ali, S.M. ... mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery Cell. 2002; 110:163-175 Full Text Full Text (PDF) Scopus (1160) PubMed Google Scholar
[64]64. Kim, D.-H. ∙ Sarbassov, D.D. ∙ Ali, S.M. ... GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR Mol. Cell. 2003; 11:895-904 Full Text Full Text (PDF) Scopus (387) PubMed Google Scholar
[65]65. Kim, J.E. ∙ Chen, J. Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation Proc. Natl. Acad. Sci. USA. 2000; 97:14340-14345 Crossref Scopus (144) PubMed Google Scholar
[66]66. Kim, W.Y. ∙ Kaelin, W.G. Role of VHL gene mutation in human cancer J. Clin. Oncol. 2004; 22:4991-5004 Crossref Scopus (463) PubMed Google Scholar
[67]67. Kovacina, K.S. ∙ Park, G.Y. ∙ Bae, S.S. ... Identification of a proline-rich Akt substrate as a 14–3-3 binding partner J. Biol. Chem. 2003; 278:10189-10194 Crossref Scopus (157) Google Scholar
[68]68. Kwiatkowski, D.J. ∙ Zhang, H. ∙ Bandura, J.L. ... A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells Hum. Mol. Genet. 2002; 11:525-534 Crossref PubMed Google Scholar
[69]69. Lee, S. ∙ Comer, F.I. ∙ Sasaki, A. ... TOR Complex 2 Integrates Cell Movement during Chemotaxis and Signal Relay in Dictyostelium Mol. Biol. Cell. 2005; 16:4572-4583 Crossref Scopus (103) Google Scholar
[70]70. Lee, S. ∙ Parent, C.A. ∙ Insall, R. ... A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium Mol. Biol. Cell. 1999; 10:2829-2845 Crossref Google Scholar
[71]71. Li, W. ∙ Petrimpol, M. ∙ Molle, K.D. ... Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2 Circ. Res. 2007; 100:79-87 Crossref Scopus (58) PubMed Google Scholar
[72]72. Liang, J. ∙ Shao, S.H. ∙ Xu, Z.X. ... The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis Nat. Cell Biol. 2007; 9:218-224 Crossref Scopus (328) PubMed Google Scholar
[73]73. Liu, X. ∙ Zheng, X.F. Endoplasmic reticulum and Golgi localization sequences for Mammalian target of rapamycin Mol. Biol. Cell. 2007; 18:1073-1082 Crossref Scopus (47) Google Scholar
[75]75. Ma, L. ∙ Chen, Z. ∙ Erdjument-Bromage, H. ... Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis Cell. 2005; 121:179-193 Full Text Full Text (PDF) Scopus (536) PubMed Google Scholar
[76]76. Ma, L. ∙ Teruya-Feldstein, J. ∙ Behrendt, N. ... Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression Genes Dev. 2005; 19:1779-1786 Crossref Scopus (68) PubMed Google Scholar
[78]78. Manning, B.D. Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis J. Cell Biol. 2004; 167:399-403 Crossref Scopus (270) PubMed Google Scholar
[79]79. Manning, B.D. ∙ Logsdon, M.N. ∙ Lipovsky, A.I. ... Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2 Genes Dev. 2005; 19:1773-1778 Crossref Scopus (155) PubMed Google Scholar
[80]80. Manning, B.D. ∙ Tee, A.R. ∙ Logsdon, M.N. ... Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway Mol. Cell. 2002; 10:151-162 Full Text Full Text (PDF) Scopus (771) PubMed Google Scholar
[81]81. McManus, E.J. ∙ Collins, B.J. ∙ Ashby, P.R. ... The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation EMBO J. 2004; 23:2071-2082 Crossref Scopus (82) Google Scholar
[82]82. Murakami, M. ∙ Ichisaka, T. ∙ Maeda, M. ... mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells Mol. Cell. Biol. 2004; 24:6710-6718 Crossref Scopus (241) PubMed Google Scholar
[83]83. Neshat, M.S. ∙ Mellinghoff, I.K. ∙ Tran, C. ... Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR Proc. Natl. Acad. Sci. USA. 2001; 98:10314-10319 Crossref Scopus (735) PubMed Google Scholar
[84]84. Nobukuni, T. ∙ Joaquin, M. ∙ Roccio, M. ... Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase Proc. Natl. Acad. Sci. USA. 2005; 102:14238-14243 Crossref Scopus (416) PubMed Google Scholar
[85]85. Paik, J.H. ∙ Kollipara, R. ∙ Chu, G. ... FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis Cell. 2007; 128:309-323 Full Text Full Text (PDF) Scopus (417) PubMed Google Scholar
[86]86. Pearce, L.R. ∙ Huang, X. ∙ Boudeau, J. ... Identification of Protor as a novel Rictor-binding component of mTOR-complex-2 Biochem. J. 2007; In press. Published online April 27, 2007 Crossref Scopus (154) Google Scholar
[87]87. Phung, T.L. ∙ Ziv, K. ∙ Dabydeen, D. ... Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin Cancer Cell. 2006; 10:159-170 Full Text Full Text (PDF) Scopus (181) PubMed Google Scholar
[88]88. Podsypanina, K. ∙ Ellenson, L.H. ∙ Nemes, A. ... Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems Proc. Natl. Acad. Sci. USA. 1999; 96:1563-1568 Crossref Scopus (600) PubMed Google Scholar
[89]89. Podsypanina, K. ∙ Lee, R.T. ∙ Politis, C. ... An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice Proc. Natl. Acad. Sci. USA. 2001; 98:10320-10325 Crossref Scopus (471) PubMed Google Scholar
[90]90. Potente, M. ∙ Urbich, C. ∙ Sasaki, K. ... Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization J. Clin. Invest. 2005; 115:2382-2392 Crossref Scopus (191) PubMed Google Scholar
[91]91. Recher, C. ∙ Dos Santos, C. ∙ Demur, C. ... mTOR, a new therapeutic target in acute myeloid leukemia Cell Cycle. 2005; 4:1540-1549 Crossref PubMed Google Scholar
[92]92. Reiling, J.H. ∙ Sabatini, D.M. Stress and mTORture signaling Oncogene. 2006; 25:6373-6383 Crossref Scopus (171) PubMed Google Scholar
[93]93. Roux, P.P. ∙ Ballif, B.A. ∙ Anjum, R. ... Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase Proc. Natl. Acad. Sci. USA. 2004; 101:13489-13494 Crossref Scopus (341) PubMed Google Scholar
[94]94. Rudelius, M. ∙ Pittaluga, S. ∙ Nishizuka, S. ... Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma Blood. 2006; 108:1668-1676 Crossref Scopus (118) PubMed Google Scholar
[95]95. Sabatini, D.M. ∙ Barrow, R.K. ∙ Blackshaw, S. ... Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling Science. 1999; 284:1161-1164 Crossref Scopus (118) PubMed Google Scholar
[98]98. Sarbassov, D. ∙ Ali, S.M. ∙ Sabatini, D.M. Growing roles for the mTOR pathway Curr. Opin. Cell Biol. 2005; 17:596-603 Crossref Scopus (748) PubMed Google Scholar
[99]99. Sarbassov, D. ∙ Ali, S.M. ∙ Sengupta, S. ... Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB Mol. Cell. 2006; 22:159-168 Full Text Full Text (PDF) Scopus (1019) PubMed Google Scholar
[100]100. Sarbassov, D. ∙ Sabatini, D.M. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex J. Biol. Chem. 2005; 280:39505-39509 Crossref Scopus (86) PubMed Google Scholar
[101]101. Sarbassov, D.D. ∙ Ali, S.M. ∙ Kim, D.H. ... Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton Curr. Biol. 2004; 14:1296-1302 Full Text Full Text (PDF) Scopus (973) PubMed Google Scholar
[103]103. Schalm, S.S. ∙ Fingar, D.C. ∙ Sabatini, D.M. ... TOS Motif-Mediated Raptor Binding Regulates 4E–BP1 Multisite Phosphorylation and Function Curr. Biol. 2003; 13:797-806 Full Text Full Text (PDF) Scopus (213) Google Scholar
[104]104. Schroder, W. ∙ Cloonan, N. ∙ Bushell, G. ... Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene Gene. 2004; 339:17-23 Crossref Scopus (18) Google Scholar
[105]105. Schroder, W.A. ∙ Buck, M. ∙ Cloonan, N. ... Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signallling Cell. Signal. 2007; in press Google Scholar
[106]106. Sekulic, A. ∙ Hudson, C.C. ∙ Homme, J.L. ... A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells Cancer Res. 2000; 60:3504-3513 PubMed Google Scholar
[107]107. Shaw, R.J. ∙ Bardeesy, N. ∙ Manning, B.D. ... The LKB1 tumor suppressor negatively regulates mTOR signaling Cancer Cell. 2004; 6:91-99 Full Text Full Text (PDF) Scopus (508) PubMed Google Scholar
[108]108. Shiota, C. ∙ Woo, J.T. ∙ Lindner, J. ... Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability Dev. Cell. 2006; 11:583-589 Full Text Full Text (PDF) Scopus (183) PubMed Google Scholar
[109]109. Skeen, J.E. ∙ Bhaskar, P.T. ∙ Chen, C.C. ... Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner Cancer Cell. 2006; 10:269-280 Full Text Full Text (PDF) Scopus (106) Google Scholar
[110]110. Smith, E.M. ∙ Finn, S.G. ∙ Tee, A.R. ... The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses J. Biol. Chem. 2005; 280:18717-18727 Crossref Scopus (191) PubMed Google Scholar
[111]111. Sodhi, A. ∙ Chaisuparat, R. ∙ Hu, J. ... The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor Cancer Cell. 2006; 10:133-143 Full Text Full Text (PDF) Scopus (89) PubMed Google Scholar
[112]112. Sodhi, A. ∙ Montaner, S. ∙ Patel, V. ... Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor Proc. Natl. Acad. Sci. USA. 2004; 101:4821-4826 Crossref Scopus (85) PubMed Google Scholar
[113]113. Stallone, G. ∙ Schena, A. ∙ Infante, B. ... Sirolimus for Kaposi's sarcoma in renal-transplant recipients N. Engl. J. Med. 2005; 352:1317-1323 Crossref Scopus (501) PubMed Google Scholar
[114]114. Staveley, B.E. ∙ Ruel, L. ∙ Jin, J. ... Genetic analysis of protein kinase B (AKT) in Drosophila Curr. Biol. 1998; 8:599-602 Full Text Full Text (PDF) PubMed Google Scholar
[115]115. Suzuki, A. ∙ de la Pompa, J.L. ∙ Stambolic, V. ... High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice Curr. Biol. 1998; 8:1169-1178 Full Text Full Text (PDF) PubMed Google Scholar
[118]118. Tirado, O.M. ∙ Mateo-Lozano, S. ∙ Sanders, S. ... The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation Cancer Res. 2003; 63:6290-6298 PubMed Google Scholar
[120]120. Um, S.H. ∙ Frigerio, F. ∙ Watanabe, M. ... Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity Nature. 2004; 431:200-205 Crossref Scopus (757) PubMed Google Scholar
[121]121. Urano, J. ∙ Comiso, M.J. ∙ Guo, L. ... Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast Mol. Microbiol. 2005; 58:1074-1086 Crossref Scopus (54) Google Scholar
[122]122. Uritani, M. ∙ Hidaka, H. ∙ Hotta, Y. ... Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase Genes Cells. 2006; 11:1367-1379 Crossref Scopus (49) Google Scholar
[123]123. Wan, X. ∙ Harkavy, B. ∙ Shen, N. ... Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism Oncogene. 2007; 26:1932-1940 Published online September 25, 2006 Crossref Scopus (322) Google Scholar
[124]124. Wang, H. ∙ Kubica, N. ∙ Ellisen, L.W. ... Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1 J. Biol. Chem. 2006; 281:39128-39134 Crossref Scopus (90) PubMed Google Scholar
[125]125. Williams, M.E. ∙ Densmore, J.J. Biology and therapy of mantle cell lymphoma Curr. Opin. Oncol. 2005; 17:425-431 Crossref Scopus (31) Google Scholar
[126]126. Withers, D.J. ∙ Ouwens, D.M. ∙ Nave, B.T. ... Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells Biochem. Biophys. Res. Commun. 1997; 241:704-709 Crossref Scopus (58) Google Scholar
[127]127. Witzig, T.E. ∙ Geyer, S.M. ∙ Ghobrial, I. ... Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma J. Clin. Oncol. 2005; 23:5347-5356 Crossref Scopus (331) PubMed Google Scholar
[128]128. Witzig, T.E. ∙ Kaufmann, S.H. Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies Curr. Treat. Options Oncol. 2006; 7:285-294 Crossref Scopus (68) Google Scholar
[129]129. Wullschleger, S. ∙ Loewith, R. ∙ Hall, M.N. TOR signaling in growth and metabolism Cell. 2006; 124:471-484 Full Text Full Text (PDF) Scopus (2271) PubMed Google Scholar
[130]130. Yang, Q. ∙ Inoki, K. ∙ Ikenoue, T. ... Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity Genes Dev. 2006; 20:2820-2832 Crossref Scopus (215) PubMed Google Scholar
[131]131. Yang, Z.Z. ∙ Tschopp, O. ∙ Di-Poi, N. ... Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice Mol. Cell. Biol. 2005; 25:10407-10418 Crossref Scopus (101) PubMed Google Scholar
[133]133. Yilmaz, O.H. ∙ Valdez, R. ∙ Theisen, B.K. ... Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells Nature. 2006; 441:475-482 Crossref Scopus (668) PubMed Google Scholar
[134]134. Yokogami, K. ∙ Wakisaka, S. ∙ Avruch, J. ... Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR Curr. Biol. 2000; 10:47-50 Full Text Full Text (PDF) Scopus (218) PubMed Google Scholar
[135]135. Zeng, Z. ∙ Sarbassov, D.D. ∙ Samudio, I.J. ... Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML Blood. 2007; 109:3509-3512 Published online December 19, 2006 Crossref Scopus (193) Google Scholar
[136]136. Zhang, H. ∙ Bajraszewski, N. ∙ Wu, E. ... PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR J. Clin. Invest. 2007; 117:730-738 Crossref Scopus (146) PubMed Google Scholar
[137]137. Zhang, H.H. ∙ Lipovsky, A.I. ∙ Dibble, C.C. ... S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt Mol. Cell. 2006; 24:185-197 Full Text Full Text (PDF) Scopus (112) Google Scholar

Sorted by citations

Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744 · see citing works
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941 · see citing works
Self-citation
Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558 · see citing works
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · see citing works
Self-citation
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076 · see citing works
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002 · see citing works
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2676 · Cited by 1,943 · see citing works
The functions and regulation of the PTEN tumour suppressor
Song, M. S., Salmena, L., & Pandolfi, P. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3330 · Cited by 1,926 · see citing works
Role of autophagy in cancer
Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798 · see citing works
Principles of cancer therapy: oncogene and non-oncogene addiction
Luo, J., Solimini, N. L., & Elledge, S. J. (2009) · Cell · doi:10.1016/j.cell.2009.02.024 · Cited by 1,765 · see citing works
Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
Park, E. J., Lee, J. H., Yu, G.-Y., He, G., Ali, S. R., Holzer, R. G., Österreicher, C. H., Takahashi, H., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2009.12.052 · Cited by 1,764 · see citing works
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686 · see citing works
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
Samuel, V. T., & Shulman, G. I. (2016) · Journal of Clinical Investigation · doi:10.1172/jci77812 · Cited by 1,484 · see citing works
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
Huang, J., & Manning, B. D. (2008) · Biochemical Journal · doi:10.1042/bj20080281 · Cited by 1,237 · see citing works
The role of the Atg1/ULK1 complex in autophagy regulation
Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062 · see citing works
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881 · see citing works
Hypoxia signalling through mTOR and the unfolded protein response in cancer
Wouters, B. G., & Koritzinsky, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2501 · Cited by 894 · see citing works
Targeting the translation machinery in cancer
Bhat, M., Robichaud, N., Hulea, L., Sonenberg, N., Pelletier, J., & Topisirovic, I. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4505 · Cited by 799 · see citing works
The mTOR Signalling Pathway in Human Cancer
Pópulo, H., Lopes, J. M., & Soares, P. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13021886 · Cited by 830 · see citing works
Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases
Samuel, V. T., & Shulman, G. I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.002 · Cited by 745 · see citing works
“and mechanistic target of rapamycin complex 2 (mTORC2) (Guertin and Sabatini, 2007), which converge on Akt phosphorylation (Alessi et al.”
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
Polivka, J., & Janku, F. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.004 · Cited by 765 · see citing works
Hypoxia regulates TSC1/2–mTOR signaling and tumor suppression through REDD1-mediated 14–3–3 shuttling
DeYoung, M. P., Horak, P., Sofer, A., Sgroi, D., & Ellisen, L. W. (2008) · Genes & Development · doi:10.1101/gad.1617608 · Cited by 710 · see citing works
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644 · see citing works
The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
Tsun, Z.-Y., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E., & Sabatini, D. M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.016 · Cited by 565 · see citing works
Self-citation
Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders
Gao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516 · see citing works
“The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that responds to environmental signals by controlling cell growth and proliferation [263, 264], synaptogenesis [213], and dendrite [265, 266] and axon growth [213, 267] in neurons via regulation of protein translation and hence plays an important ro…”
Background
Cellular and molecular biology of aging endothelial cells
Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538 · see citing works
Melanoma: from mutations to medicine
Tsao, H., Chin, L., Garraway, L. A., & Fisher, D. E. (2012) · Genes & Development · doi:10.1101/gad.191999.112 · Cited by 496 · see citing works
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
Polak, P., Cybulski, N., Feige, J. N., Auwerx, J., Rüegg, M. A., & Hall, M. N. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.003 · Cited by 480 · see citing works
Neuronal Intrinsic Mechanisms of Axon Regeneration
Liu, K., Tedeschi, A., Park, K. K., & He, Z. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113723 · Cited by 458 · see citing works
mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
Rodrik-Outmezguine, V. S., Chandarlapaty, S., Pagano, N. C., Poulikakos, P. I., Scaltriti, M., Moskatel, E., Baselga, J., Guichard, S., & Rosen, N. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0085 · Cited by 442 · see citing works
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., Mcburnie, W., Fleming, S., & Alessi, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20080557 · Cited by 396 · see citing works
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
Wellen, K. E., Lu, C., Mancuso, A., Lemons, J. M. S., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., & Thompson, C. B. (2010) · Genes & Development · doi:10.1101/gad.1985910 · Cited by 377 · see citing works
MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors
Turke, A. B., Song, Y., Costa, C., Cook, R., Arteaga, C. L., Asara, J. M., & Engelman, J. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3747 · Cited by 368 · see citing works
Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development
Pelletier, J., Graff, J., Ruggero, D., & Sonenberg, N. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2789 · Cited by 367 · see citing works
Post-Transplant Diabetes Mellitus: Causes, Treatment, and Impact on Outcomes
Shivaswamy, V., Boerner, B., & Larsen, J. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1084 · Cited by 328 · see citing works
Regulation of Ketone Body Metabolism and the Role of PPARα
Grabacka, M., Pierzchalska, M., Dean, M., & Reiss, K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122093 · Cited by 305 · see citing works
mTORC2 controls actin polymerization required for consolidation of long-term memory
Huang, W., Zhu, P. J., Zhang, S., Zhou, H., Stoica, L., Galiano, M., Krnjević, K., Roman, G., & Costa-Mattioli, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3351 · Cited by 307 · see citing works
Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications
Ostrovidov, S., Hosseini, V., Ahadian, S., Fujie, T., Parthiban, S. P., Ramalingam, M., Bae, H., Kaji, H., & Khademhosseini, A. (2014) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2013.0534 · Cited by 302 · see citing works
mTORC1 promotes survival through translational control of Mcl-1
Mills, J. R., Hippo, Y., Robert, F., Chen, S. M. H., Malina, A., Lin, C.-J., Trojahn, U., Wendel, H.-G., Charest, A., Bronson, R. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804821105 · Cited by 285 · see citing works
Poly(ADP-ribose) signaling in cell death
Virág, L., Robaszkiewicz, A., Rodriguez-Vargas, J. M., & Oliver, F. J. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.01.007 · Cited by 273 · see citing works
Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship
Jhanwar-Uniyal, M., Wainwright, J. V., Mohan, A. L., Tobias, M. E., Murali, R., Gandhi, C. D., & Schmidt, M. H. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2019.03.003 · Cited by 268 · see citing works
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
Jung, J., Genau, H. M., & Behrends, C. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00125-15 · Cited by 266 · see citing works
mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α
Cam, H., Easton, J. B., High, A., & Houghton, P. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.030 · Cited by 266 · see citing works
Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1<i>H</i>)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer
Liu, Q., Chang, J. W., Wang, J., Kang, S. A., Thoreen, C. C., Markhard, A., Hur, W., Zhang, J., Sim, T., Sabatini, D. M., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm101144f · Cited by 257 · see citing works
Self-citation
Asbestos-induced lung diseases: an update
Kamp, D. W. (2009) · Translational Research · doi:10.1016/j.trsl.2009.01.004 · Cited by 251 · see citing works
Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
Stoica, L., Zhu, P. J., Huang, W., Zhou, H., Kozma, S. C., & Costa-Mattioli, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014715108 · Cited by 232 · see citing works
Targeting lysosomes in human disease: from basic research to clinical applications
Cao, M., Luo, X., Wu, K., & He, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00778-y · Cited by 225 · see citing works
Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors
Doghman, M., Wakil, A. E., Cardinaud, B., Thomas, E., Wang, J., Zhao, W., Peralta-Del Valle, M. H. C., Figueiredo, B. C., Zambetti, G. P., & Lalli, E. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3970 · Cited by 221 · see citing works
Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
Zakikhani, M., Blouin, M.-J., Piura, E., & Pollak, M. N. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0763-9 · Cited by 213 · see citing works
Stressin’ Sestrins take an aging fight
Budanov, A. V., Lee, J. H., & Karin, M. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000097 · Cited by 208 · see citing works
The coordination of nuclear and mitochondrial communication during aging and calorie restriction
Finley, L. W. S., & Haigis, M. C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.03.003 · Cited by 207 · see citing works
Accelerated wound healing by mTOR activation in genetically defined mouse models
Squarize, C. H., Castilho, R. M., Bugge, T. H., & Gutkind, J. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010643 · Cited by 203 · see citing works
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
Green, A. S., Chapuis, N., Trovati Maciel, T., Willems, L., Lambert, M., Arnoult, C., Boyer, O., Bardet, V., Park, S., Foretz, M., et al. (2010) · Blood · doi:10.1182/blood-2010-02-269837 · Cited by 199 · see citing works
EGFR-mutated lung cancer: a paradigm of molecular oncology
Zhang, Z., Stiegler, A. L., Boggon, T. J., Kobayashi, S., & Halmos, B. (2010) · Oncotarget · doi:10.18632/oncotarget.186 · Cited by 197 · see citing works
Role of Mutagenicity in Asbestos Fiber-Induced Carcinogenicity and Other Diseases
Huang, S. X. L., Jaurand, M.-C., Kamp, D. W., Whysner, J., & Hei, T. K. (2011) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2011.556051 · Cited by 163 · see citing works
Lysosomal recruitment of TSC2 is a universal response to cellular stress
Demetriades, C., Plescher, M., & Teleman, A. A. (2016) · Nature Communications · doi:10.1038/ncomms10662 · Cited by 160 · see citing works
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2
Kovalski, J. R., Bhaduri, A., Zehnder, A. M., Neela, P. H., Che, Y., Wozniak, G. G., & Khavari, P. A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.12.001 · Cited by 154 · see citing works
Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners
Sarfstein, R., Friedman, Y., Attias-Geva, Z., Fishman, A., Bruchim, I., & Werner, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061537 · Cited by 150 · see citing works
What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway
Klempner, S. J., Myers, A. P., & Cantley, L. C. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0063 · Cited by 148 · see citing works
Glutaminolysis and autophagy in cancer
Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V. (2015) · Autophagy · doi:10.1080/15548627.2015.1053680 · Cited by 143 · see citing works
Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model
Czerninski, R., Amornphimoltham, P., Patel, V., Molinolo, A. A., & Gutkind, J. S. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0147 · Cited by 140 · see citing works
Protein, amino acids and obesity treatment
Simonson, M., Boirie, Y., & Guillet, C. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09574-5 · Cited by 128 · see citing works
The role of Pdcd4 in tumour suppression and protein translation
Wang, Q., & Yang, H. (2018) · Biology of the Cell · doi:10.1111/boc.201800014 · Cited by 113 · see citing works
Adult Stem Cells and Diseases of Aging
Boyette, L., & Tuan, R. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3010088 · Cited by 108 · see citing works
Reactive Oxygen Species a Double-Edged Sword for Mesothelioma
Benedetti, S., Nuvoli, B., Catalani, S., & Galati, R. (2015) · Oncotarget · doi:10.18632/oncotarget.4253 · Cited by 97 · see citing works
Crystal structure of the Gtr1p–Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
Gong, R., Li, L., Liu, Y., Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K.-L., & Xu, Y. (2011) · Genes & Development · doi:10.1101/gad.16968011 · Cited by 98 · see citing works
mTOR-Dependent Cell Proliferation in the Brain
Ryskalin, L., Lazzeri, G., Flaibani, M., Biagioni, F., Gambardella, S., Frati, A., & Fornai, F. (2017) · BioMed Research International · doi:10.1155/2017/7082696 · Cited by 86 · see citing works
Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels
Fallica, B., Maffei, J. S., Villa, S., Makin, G., & Zaman, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048024 · Cited by 84 · see citing works
Prolyl hydroxylases as regulators of cell metabolism
Boulahbel, H., Durán, R. V., & Gottlieb, E. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370291 · Cited by 82 · see citing works
Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition
Shi, X., Miller, J. S., Harper, L. J., Poole, R. L., Gould, T. J., & Unterwald, E. M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3491-8 · Cited by 79 · see citing works
Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration
Kaur, G., Tan, L. X., Rathnasamy, G., La Cunza, N., Germer, C. J., Toops, K. A., Fernandes, M., Blenkinsop, T. A., & Lakkaraju, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805039115 · Cited by 79 · see citing works
CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation
Murooka, T. T., Rahbar, R., & Fish, E. N. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.035 · Cited by 78 · see citing works
Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF-mutant melanoma
Wang, B., Zhang, W., Zhang, G., Kwong, L., Lu, H., Tan, J., Sadek, N., Xiao, M., Zhang, J., Labrie, M., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01911-5 · Cited by 66 · see citing works
FIP200, a key signaling node to coordinately regulate various cellular processes
Gan, B., & Guan, J.-L. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.021 · Cited by 67 · see citing works
The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth, and chemosensitivity under hypoxic conditions
Matthew, E. M., Hart, L. S., Astrinidis, A., Navaraj, A., Dolloff, N. G., Dicker, D. T., Henske, E. P., & El-Deiry, W. S. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10800 · Cited by 67 · see citing works
Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma
Wang, Q., Zhu, J., Wang, Y.-W., Dai, Y., Wang, Y.-L., Wang, C., Liu, J., Baker, A., Colburn, N. H., & Yang, H.-S. (2017) · Oncogene · doi:10.1038/onc.2017.228 · Cited by 67 · see citing works
Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions
Amornphimoltham, P., Leelahavanichkul, K., Molinolo, A., Patel, V., & Gutkind, J. S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0703 · Cited by 63 · see citing works
mTOR mediates a mechanism of resistance to chemotherapy and defines a rational combination strategy to treat KRAS-mutant lung cancer
Liang, S.-Q., Bührer, E. D., Berezowska, S., Marti, T. M., Xu, D., Froment, L., Yang, H., Hall, S. R. R., Vassella, E., Yang, Z., et al. (2019) · Oncogene · doi:10.1038/s41388-018-0479-6 · Cited by 55 · see citing works
A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer
Auslander, N., Yizhak, K., Weinstock, A., Budhu, A., Tang, W., Wang, X. W., Ambs, S., & Ruppin, E. (2016) · Scientific Reports · doi:10.1038/srep29662 · Cited by 50 · see citing works
Metabolic reprogramming: a bridge between aging and tumorigenesis
Drapela, S., Ilter, D., & Gomes, A. P. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13261 · Cited by 41 · see citing works
Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling
Xia, J., Wang, R., Zhang, T., & Ding, J. (2016) · Cell Discovery · doi:10.1038/celldisc.2016.35 · Cited by 38 · see citing works
20‐<i>O</i>‐β‐d‐Glucopyranosyl‐20(S)‐Protopanaxadiol Suppresses UV‐Induced MMP‐1 Expression Through AMPK‐Mediated mTOR Inhibition as a Downstream of the PKA‐LKB1 Pathway
Shin, D. J., Kim, J., Lim, T., Jeong, E. H., Park, G., Kang, N. J., Park, J., Yeom, M., Oh, D. K., Bode, A. M., et al. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24833 · Cited by 37 · see citing works
New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft‐versus‐host disease
Lutz, M., & Mielke, S. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13022 · Cited by 32 · see citing works
Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas
Bi, C., Zhang, X., Lu, T., Zhang, X., Wang, X., Meng, B., Zhang, H., Wang, P., Vose, J. M., Chan, W. C., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.159160 · Cited by 32 · see citing works
RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death
Fettweis, G., Di Valentin, E., L'homme, L., Lassence, C., Dequiedt, F., Fillet, M., Coupienne, I., & Piette, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.10.014 · Cited by 26 · see citing works
Analysis of TSC1 truncations defines regions involved in TSC1 stability, aggregation and interaction
Hoogeveen-Westerveld, M., Exalto, C., Maat-Kievit, A., van den Ouweland, A., Halley, D., & Nellist, M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.06.004 · Cited by 25 · see citing works
The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits
Hoogeveen-Westerveld, M., van Unen, L., van den Ouweland, A., Halley, D., Hoogeveen, A., & Nellist, M. (2012) · BMC Biochemistry · doi:10.1186/1471-2091-13-18 · Cited by 24 · see citing works
Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR
Skoufou-Papoutsaki, N., Adler, S., D'Santos, P., Mannion, L., Mehmed, S., Kemp, R., Smith, A., Perrone, F., Nayak, K., Russell, A., et al. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050279 · Cited by 22 · see citing works
“This pathway is an important regulator of cell proliferation and metabolism (Hay and Sonenberg, 2004; Guertin and Sabatini, 2007). mTORC1 is also known to be important for controlling cell size, with activated mTORC1 leading to larger cells (Fingar et al., 2002).”
PTEN in Regulating Hematopoiesis and Leukemogenesis
Wu, Y., Zhu, H., & Wu, H. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036244 · Cited by 22 · see citing works
Genes related to heat tolerance in cattle—a review
Zeng, L., Qu, K., Zhang, J., Huang, B., & Lei, C. (2023) · Animal Biotechnology · doi:10.1080/10495398.2022.2047995 · Cited by 13 · see citing works

Authors: Guertin, D. A., & Sabatini, D. M.
Affiliations: Broad Institute (US)
Corresponding author: Sabatini, David M.
ORCID: Guertin, David A.
Sabatini, David M.
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2007-07
Volume: 12
Issue: 1
Pages: 9-22
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/j.ccr.2007.05.008
OpenAlex: W2080100938
Cited by: 2,833
References: 10
Citations by year: 2026: 25 · 2025: 64 · 2024: 58 · 2023: 101 · 2022: 103 · 2021: 110 · 2020: 127 · 2019: 128 · 2018: 153 · 2017: 141 · 2016: 180 · 2015: 223 · 2014: 213 · 2013: 210 · 2012: 203
FWCI: 14.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2208 d)
Locations: Cancer Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: mTOR, mammalian target of rapamycin, rapamycin, mTOR inhibitors, signal transduction, cancer, mTOR signaling, targeted cancer therapy, rapamycin derivatives
MeSH terms: Antineoplastic Agents, Humans, Neoplasms, Protein Kinases, Signal Transduction, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Defining the role of mTOR in cancer

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Record

About these checks