The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Systemic Infusion of FLK1+ Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis in Mice
Abstract
BACKGROUND: Fibrosis is the common end stage of most liver diseases, for which, unfortunately, there is no effective treatment available currently. It has been shown that mesenchymal stem cells (MSCs) from bone marrow (BM) could engraft in the lung after bleomycin exposure and ameliorate its fibrotic effects. This study was designed to evaluate the effect of Flk1 MSCs from murine BM (termed here Flk1 mMSCs) on fibrosis formation induced by carbon tetrachloride (CCl4). METHODS: A CCl(4)-induced hepatic fibrosis model was used. Flk1 mMSCs were systemically infused immediately or 1 week after mice were challenged with CCl(4). Control mice received only saline infusion. Fibrosis index and donor-cell engraftment were assessed 2 or 5 weeks after CCl(4) challenge. RESULTS: We found that Flk1 mMSCs transplantation immediately, but not 1 week after exposure to CCl(4), significantly reduced CCl(4)-induced liver damage and collagen deposition. In addition, levels of hepatic hydroxyproline and serum fibrosis markers in mice receiving immediate Flk1 mMSCs transplantation after CCl(4) challenge were significantly lower compared with those of control mice. More importantly, histologic examination suggested that hepatic damage recovery was much better in these immediately Flk1 mMSCs-treated mice. Immunofluorescence, polymerase chain reaction, and fluorescence in situ hybridization analysis revealed that donor cells engrafted into host liver, had epithelium-like morphology, and expressed albumin, although at low frequency. CONCLUSION: These results suggest that Flk1 mMSCs might initiate endogenous hepatic tissue regeneration, engraft into host liver in response to CCl(4) injury, and ameliorate its fibrogenic effects.
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1 retracted
Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells
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RetractedBone marrow cells regenerate infarcted myocardium
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Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
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Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
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Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow
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Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
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Cell fusion is the principal source of bone-marrow-derived hepatocytes
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Transplanted bone marrow regenerates liver by cell fusion
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Cited by
In Search of the In Vivo Identity of Mesenchymal Stem Cells
da Silva Meirelles, L., Caplan, A. I., & Nardi, N. B. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1122 · Cited by 1,077
Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration
Kode, J. A., Mukherjee, S., Joglekar, M. V., & Hardikar, A. A. (2009) · Cytotherapy · doi:10.1080/14653240903080367 · Cited by 384
Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury
Moodley, Y., Atienza, D., Manuelpillai, U., Samuel, C. S., Tchongue, J., Ilancheran, S., Boyd, R., & Trounson, A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080629 · Cited by 356
Shi, M., Li, J., Liao, L., Chen, B., Li, B., Chen, L., Jia, H., & Zhao, R. C. (2007) · Haematologica · doi:10.3324/haematol.10669 · Cited by 339
Self-citationFunctional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers
Aurich, I., Mueller, L. P., Aurich, H., Luetzkendorf, J., Tisljar, K., Dollinger, M. M., Schormann, W., Walldorf, J., Hengstler, J. G., Fleig, W. E., et al. (2007) · Gut · doi:10.1136/gut.2005.090050 · Cited by 314
Metadata
- Authors
- Fang, B., Shi, M., Liao, L., Yang, S., Liu, Y., & Zhao, R. C.
- Venue
- Transplantation
- Published
- 2004-07-15
- Volume
- 78
- Issue
- 1
- Pages
- 83-88
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W1974445411
- Cited by
- 271
- References
- 27
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Systemic Infusion of FLK1+ Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis in Mice. https://app.cochat.ai/papers/10.1097/01.tp.0000128326.95294.14
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- Fang, B., Shi, M., Liao, L., Yang, S., Liu, Y., & Zhao, R. C. (2004). Systemic Infusion of FLK1+ Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis in Mice. Transplantation. https://doi.org/10.1097/01.tp.0000128326.95294.14
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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