The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Contrasting CD25hiCD4+T Cells/FOXP3 Patterns in Chronic Rejection and Operational Drug-Free Tolerance
Abstract
BACKGROUND: Although immunosuppression withdrawal in kidney recipients usually leads to rejection, in some patients it does not, leading to a state of clinical operational tolerance. METHODS: We compared these highly contrasted situations by analyzing blood cell phenotype and transcriptional patterns in drug-free spontaneously tolerant kidney recipients, recipients with chronic rejection, recipients with stable graft function under standard or minimal immunosuppression and healthy individuals RESULTS: The blood cell phenotype of clinically tolerant patients did not differ from that of healthy individuals. In contrast, recipients with chronic rejection had significantly less CD25hiCD4+T cells and lower levels of FOXP3 transcripts compared with clinically tolerant recipients. Patients with chronic rejection also displayed CD25-CD4+T cells expressing NKG2D+CD94+ and CD57+CD27-CD28- cytotoxic-associated markers (P<0.05). CONCLUSION: These data show that whereas clinically tolerant recipients displayed normal levels of CD25hiCD4+T cells and FOXP3 transcripts, chronic rejection is associated with a decrease in CD25hiCD4+T cells and FOXP3 transcripts, suggesting that clinically "operational tolerance" may be due to a maintained phenomenon of natural tolerance that is lacking in patients with chronic rejection.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
CD4+CD25high Regulatory Cells in Human Peripheral Blood
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Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
Viglietta, V., Baecher-Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,856
Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Hariharan, S., Johnson, C. P., Bresnahan, B. A., Taranto, S. E., McIntosh, M. J., & Stablein, D. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003023420901 · Cited by 1,835
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Regulatory T cells in transplantation tolerance
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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells
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Cited by
Multiparameter Immune Profiling of Operational Tolerance in Liver Transplantation
Martínez-Llordella, M., Puig-Pey, I., Orlando, G., Ramoni, M., Tisone, G., Rimola, A., Lerut, J., Latinne, D., Margarit, C., Bilbao, I., et al. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01621.x · Cited by 374
Self-citationBrouard, S., Mansfield, E., Braud, C., Li, L., Giral, M., Hsieh, S.-C., Baeten, D., Zhang, M., Ashton-Chess, J., Braudeau, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705834104 · Cited by 373
Self-citationPons, J. A., Revilla-Nuin, B., Baroja-Mazo, A., Ramírez, P., Martínez-Alarcón, L., Sánchez-Bueno, F., Robles, R., Rios, A., Aparicio, P., & Parrilla, P. (2008) · Transplantation · doi:10.1097/tp.0b013e318188d3e6 · Cited by 179
Akimova, T., Kamath, B. M., Goebel, J. W., Meyers, K. E. C., Rand, E. B., Hawkins, A., Levine, M. H., Bucuvalas, J. C., & Hancock, W. W. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04269.x · Cited by 126
Metadata
- Authors
- Louis, S., Braudeau, C., Giral, M., Dupont, A., Moizant, F., Robillard, N., Moreau, A., Soulillou, J.-P., & Brouard, S.
- Venue
- Transplantation
- Published
- 2006-02
- Volume
- 81
- Issue
- 3
- Pages
- 398-407
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W2063820155
- Cited by
- 277
- References
- 43
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Contrasting CD25hiCD4+T Cells/FOXP3 Patterns in Chronic Rejection and Operational Drug-Free Tolerance. https://app.cochat.ai/papers/10.1097/01.tp.0000203166.44968.86
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- Louis, S., Braudeau, C., Giral, M., Dupont, A., Moizant, F., Robillard, N., Moreau, A., Soulillou, J.-P., & Brouard, S. (2006). Contrasting CD25hiCD4+T Cells/FOXP3 Patterns in Chronic Rejection and Operational Drug-Free Tolerance. Transplantation. https://doi.org/10.1097/01.tp.0000203166.44968.86
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