Evaluation of Efficacy of the Perioperative Administration of Venlafaxine or Gabapentin on Acute and Chronic Postmastectomy Pain
Abstract
Objectives: Postmastectomy pain syndrome is a neuropathic pain syndrome that is known to develop after breast surgery. Preemptive analgesia has been shown to be efficacious in reducing postoperative pain, and may be effective in reducing the incidence of certain types of neuropathic pain. We investigated the analgesic efficacy of Venlafaxine and gabapentin on acute and chronic pain associated with cancer breast surgery. Patients and Methods: The study was carried out on 150 patients scheduled for either partial or radical mastectomy with axillary dissection. They were randomized in a double-blinded manner to receive, extended release Venlafaxine 37.5 mg/d, gabapentin 300 mg/d, or placebo for 10 days starting the night before operation. Pain scores were recorded at rest and movement (visual analog scale) at 4, 12, and 24 hours on the first day postoperatively, daily from the second to tenth day postoperatively and visual analog scale in addition to pain character 6 months later. Analgesic requirements were compared between the 3 groups. Results: Pain after movement was reduced by gabapentin from the second to tenth postoperative day and venlafaxine group in the last 3 days but no difference was found between the groups regarding pain during rest. Gabapentin reduced morphine consumed in the first 24 hours postoperatively. The analgesic requirements from the second to tenth days for codeine and paracetamol were reduced in venlafaxine and gabapentin groups compared to the control group. Six months later, the incidence of chronic pain, its intensity, and need for analgesics were reduced in venlafaxine compared to gabapentin and the placebo group. However, burning pain was more frequent in the control groups than in the gabapentin. Conclusion: Venlafaxine 37.5 mg/d extended release or gabapentin 300 mg/d have equipotent effects (except on the first day in venlafaxine group) in reducing analgesic requirements, although gabapentin is more effective in reducing pain after movement. Venlafaxine significantly reduced the incidence of postmastectomy pain syndromes (chronic pain) 6 months in women having breast cancer surgery. Gabapentin had no effect on chronic pain except decreasing incidence of burning pain.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a study by Amr et al., venlafaxine extended-release (37.5 mg/d) significantly reduced chronic pain at 6 months compared to gabapentin (300 mg/d) in post-mastectomy pain.
“A study by Amr et al. comparing the effects of gabapentin and venlafaxine on post-mastectomy pain found that venlafaxine extended-release (37.5 mg/d) significantly reduced chronic pain at 6 months compared to gabapentin (300 mg/d)”
From Chronic postsurgical pain: current evidence for prevention and management (2018) · cites this paper as [37]
Cites
Woolf, C. J., & Chong, M.-S. (1993) · Anesthesia & Analgesia · doi:10.1213/00000539-199377020-00026 · Cited by 1,691 · see citing works
Chronic Pain as an Outcome of Surgery
Perkins, F. M., & Kehlet, H. (2000) · Anesthesiology · doi:10.1097/00000542-200010000-00038 · Cited by 1,336 · see citing works
Bach, S., Noreng, M. F., & Tjéllden, N. U. (1988) · Pain · doi:10.1016/0304-3959(88)90288-6 · Cited by 564 · see citing works
Neuropathic pain following breast cancer surgery: proposed classification and research update
Jung, B. F., Ahrendt, G. M., Oaklander, A. L., & Dworkin, R. H. (2003) · Pain · doi:10.1016/s0304-3959(03)00241-0 · Cited by 476 · see citing works
Luo, Z. D., Calcutt, N. A., Higuera, E. S., Valder, C. R., Song, Y.-H., Svensson, C. I., & Myers, R. R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041574 · Cited by 381 · see citing works
Dirks, J., Fredensborg, B. B., Christensen, D., Fomsgaard, J. S., Flyger, H., & Dahl, J. B. (2002) · Anesthesiology · doi:10.1097/00000542-200209000-00007 · Cited by 360 · see citing works
Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers
Eckhardt, K., Ammon, S., Hofmann, U., Riebe, A., Gugeler, N., & Mikus, G. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200007000-00035 · Cited by 287 · see citing works
Pandey, C. K., Priye, S., Singh, S. M., Singh, U., Singh, R. B., & Singh, P. K. (2004) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03018240 · Cited by 215 · see citing works
Pandey, C. K., Navkar, D. V., Giri, P. J., Raza, M., Behari, S., Singh, R. B., Singh, U., & Singh, P. K. (2005) · Journal of Neurosurgical Anesthesiology · doi:10.1097/01.ana.0000151407.62650.51 · Cited by 209 · see citing works
Tasmuth, T., Estlanderb, A.-M., & Kalso, E. (1996) · Pain · doi:10.1016/s0304-3959(96)03219-8 · Cited by 203 · see citing works
Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers
Eckhardt, K., Ammon, S., Hofmann, U., et al. (2000) · Anesthesia & Analgesia · doi:10.1213/00000539-200007000-00035 · Cited by 198 · see citing works
Neuropathic pain of peripheral origin
Galer, B. S. (1995) · Neurology · doi:10.1212/wnl.45.12_suppl_9.s17 · Cited by 184 · see citing works
Gabapentin and Venlafaxine for the Treatment of Painful Diabetic Neuropathy
Simpson, D. A. (2001) · Journal of Clinical Neuromuscular Disease · doi:10.1097/00131402-200112000-00002 · Cited by 182 · see citing works
Pandey, C. K., Bose, N., Garg, G., Singh, N., Baronia, A. K., Agarwal, A., Singh, P. K., & Singh, U. (2002) · Anesthesia & Analgesia · doi:10.1097/00000539-200212000-00046 · Cited by 177 · see citing works
Gabapentin use in neuropathic pain syndromes
Nicholson, B. D. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.0006a.x · Cited by 152 · see citing works
Procedures for setting normal values
O’Brien, P. C., & Dyck, P. J. (1995) · Neurology · doi:10.1212/wnl.45.1.17 · Cited by 147 · see citing works
Raja, S. N., & Veloso, K. (1992) · Anesthesiology · doi:10.1097/00000542-199205000-00044 · Cited by 141 · see citing works
Preemptive gabapentin reduces postoperative pain and opioid demand following thyroid surgery
Al-Mujadi, H., A-Refai, A. R., Katzarov, M. G., Dehrab, N. A., Batra, Y. K., & Al-Qattan, A. R. (2006) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03022214 · Cited by 126 · see citing works
Lang, E. J., Hord, H. A., & Denson, D. D. (1996) · Pain · doi:10.1016/s0304-3959(96)03223-x · Cited by 83 · see citing works
Brogly, N., Wattier, J., Andrieu, G., Bota, D. P., Robin, E., Kipnis, É., Arnalsteen, L., Thielemans, B., Carnaille, B. M. L., Pattou, F. N., et al. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318185cf73 · Cited by 82 · see citing works
Is Gabapentin a “Broad-spectrum” Analgesic?
Gilron, I. (2002) · Anesthesiology · doi:10.1097/00000542-200209000-00004 · Cited by 71 · see citing works
Venlafaxine-tramadol similarities
Markowitz, J. S., & Patrick, K. S. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90112-8 · Cited by 69 · see citing works
Al-Mujadi, H., A-Refai, A. R., Katzarov, M. G., Dehrab, N. A., Batra, Y. K., & Al-Qattan, A. R. (2006) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · Cited by 67 · see citing works
Venlafaxine hydrochloride and chronic pain.
Taylor, K., & Rowbotham, M. C. (1996) · PubMed · Cited by 49 · see citing works
Venlafaxine for the treatment of chronic pain
Songer, D. A., & Schulte, H. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.5.737a · Cited by 47 · see citing works
Venlafaxine for the Treatment of Neuropathic Pain
Pernia, A., Micó, J. A., Calderón, E. J., & Torres, L. M. (2000) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00151-2 · Cited by 44 · see citing works
New hope in the treatment of painful symptoms in depression.
Briley, M. (2003) · PubMed · Cited by 42 · see citing works
The optimal preemptive dose of gabapentin following gynecologic surgery
Kang, H. S., Park, H. J., Choi, J., Park, S. J., & Lee, S.-K. (2009) · Korean Journal of Anesthesiology · doi:10.4097/kjae.2009.56.3.309 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771 · see citing works
Poorly controlled postoperative pain: prevalence, consequences, and prevention
Gan, T. J. (2017) · Journal of Pain Research · doi:10.2147/jpr.s144066 · Cited by 1,525 · see citing works
Clarke, H., Bonin, R. P., Orser, B. A., Englesakis, M., Wijeysundera, D. N., & Katz, J. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318249d36e · Cited by 481 · see citing works
Temple‐Oberle, C. F., Shea-Budgell, M. A., Tan, M., Semple, J. L., Schrag, C. H., Barreto, M. P., Blondeel, P. N., Hamming, J., Dayan, J. H., & Ljungqvist, O. H. (2017) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000003242 · Cited by 366 · see citing works
Pharmacotherapy for the prevention of chronic pain after surgery in adults
Chaparro, L. E., Smith, S. A., Moore, A., Wiffen, P. J., & Gilron, I. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008307.pub2 · Cited by 316 · see citing works
Multimodal therapies for postoperative nausea and vomiting, and pain
Chandrakantan, A., & Glass, P. S. A. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer358 · Cited by 308 · see citing works
Jarzyna, D., Jungquist, C. R., Pasero, C., Willens, J. S., Nisbet, A., Oakes, L. L., Dempsey, S. J., Santangelo, D., & Polomano, R. C. (2011) · Pain Management Nursing · doi:10.1016/j.pmn.2011.06.008 · Cited by 253 · see citing works
Katz, J. D., Clarke, H. A., & Seltzer, Z. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31822c9a59 · Cited by 236 · see citing works
Belfer, I., Schreiber, K. L., Shaffer, J. R., Shnol, H., Blaney, K., Morando, A., Englert, D., Greco, C., Brufsky, A., Ahrendt, G., et al. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.05.002 · Cited by 217 · see citing works
Humble, S. R., Dalton, A. J., & Li, L. (2015) · European Journal of Pain · doi:10.1002/ejp.567 · Cited by 220 · see citing works
Schmidt, P. C., Ruchelli, G., Mackey, S. C., & Carroll, I. R. (2013) · Anesthesiology · doi:10.1097/aln.0b013e3182a9a896 · Cited by 193 · see citing works
Chronic postsurgical pain: current evidence for prevention and management
Thapa, P., & Euasobhon, P. (2018) · The Korean Journal of Pain · doi:10.3344/kjp.2018.31.3.155 · Cited by 177 · see citing works
Carley, M. E., Chaparro, L. E., Choinière, M., Kehlet, H., Moore, R. A., Kerkhof, E., & Gilron, I. (2021) · Anesthesiology · doi:10.1097/aln.0000000000003837 · Cited by 164 · see citing works
A systematic review and meta‐regression analysis of prophylactic gabapentin for postoperative pain
Doleman, B., Heinink, T. P., Read, D. J., Faleiro, R. J., Lund, J. N., & Williams, J. P. (2015) · Anaesthesia · doi:10.1111/anae.13179 · Cited by 158 · see citing works
Antidepressants for pain management in adults with chronic pain: a network meta-analysis
Birkinshaw, H., Friedrich, C., Cole, P., Eccleston, C., Serfaty, M. A., Stewart, G. B., White, S. P., Moore, A., Phillippo, D., & Pincus, T. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014682.pub2 · Cited by 153 · see citing works
Research design considerations for chronic pain prevention clinical trials
Gewandter, J. S., Dworkin, R. H., Turk, D. C., Farrar, J. T., Fillingim, R. B., Gilron, I., Markman, J. D., Oaklander, A. L., Polydefkis, M. J., Raja, S. N., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000191 · Cited by 143 · see citing works
Venlafaxine for neuropathic pain in adults
Gallagher, H. C., Gallagher, R. M., Butler, M., Buggy, D. J., & Henman, M. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011091.pub2 · Cited by 136 · see citing works
Persistent postoperative pain: where are we now?
Niraj, G., & Rowbotham, D. J. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer116 · Cited by 133 · see citing works
Deumens, R., Steyaert, A., Forget, P., Schubert, M., Lavand'homme, P. M., Hermans, E., & Kock, M. D. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.01.002 · Cited by 123 · see citing works
Preventing chronic postoperative pain
Reddi, D. (2015) · Anaesthesia · doi:10.1111/anae.13306 · Cited by 120 · see citing works
Evidence-based review of enhancing postoperative recovery after breast surgery
Arsalani‐Zadeh, R., Elfadl, D., Yassin, N., & Macfie, J. M. (2010) · British journal of surgery · doi:10.1002/bjs.7331 · Cited by 117 · see citing works
Vadalouca, A., Raptis, E., Μoka, Ε., Zis, P., Sykioti, P., & Siafaka, I. (2011) · Pain Practice · doi:10.1111/j.1533-2500.2011.00485.x · Cited by 116 · see citing works
Dahl, J. B., & Kehlet, H. (2011) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e328345afd9 · Cited by 116 · see citing works
Treatment of Neuropathic Pain with Venlafaxine: A Systematic Review
Aiyer, R., Barkin, R. L., & Bhatia, A. (2016) · Pain Medicine · doi:10.1093/pm/pnw261 · Cited by 114 · see citing works
Fabritius, M. L., Geisler, A. E., Petersen, P. L., Nikolajsen, L., Hansen, M. S., Kontinen, V., Hamunen, K., Dahl, J. B., Wetterslev, J., & Mathiesen, O. (2016) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12766 · Cited by 111 · see citing works
Ajit, S., Khan, J. S., Dhaliwal, J., Busse, J. W., Choi, S., Devereaux, P. J., & Clarke, H. A. (2017) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2017.05.054 · Cited by 103 · see citing works
Preventive Analgesia and Novel Strategies for the Prevention of Chronic Post-Surgical Pain
Clarke, H., Poon, M., Weinrib, A., Katznelson, R., Wentlandt, K., & Katz, J. (2015) · Drugs · doi:10.1007/s40265-015-0365-2 · Cited by 98 · see citing works
Prevention and Treatment of Chronic Postsurgical Pain: A Narrative Review
Steyaert, A., & Lavand’homme, P. (2018) · Drugs · doi:10.1007/s40265-018-0866-x · Cited by 97 · see citing works
Grosu, I., & Kock, M. D. (2011) · Anesthesiology Clinics · doi:10.1016/j.anclin.2011.04.001 · Cited by 78 · see citing works
Thekdi, S. M., Trinidad, A. C., & Roth, A. J. L. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0529-x · Cited by 77 · see citing works
Douleurs chroniques postchirurgicales
Martinez, V., Baudic, S., & Fletcher, D. (2013) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2013.04.012 · Cited by 75 · see citing works
Pectoral I Block Does Not Improve Postoperative Analgesia After Breast Cancer Surgery
Cros, J., Senges, P., Kaprelian, S., Desroches, J., Gagnon, C., Labrunie, A., Marin, B., Crépin, S., Nathan, N., & Beaulieu, P. (2018) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000779 · Cited by 72 · see citing works
Antidepressant Drugs for Prevention of Acute and Chronic Postsurgical Pain
Wong, K., Phelan, R., Kalso, E. A., Galvin, I. M., Goldstein, D. H., Raja, S. N., & Gilron, I. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000307 · Cited by 70 · see citing works
Abbas, D. N. (2018) · Pain Physician · doi:10.36076/ppj.2018.4.351 · Cited by 67 · see citing works
New Serotonin-Norepinephrine Reuptake Inhibitors and Their Anesthetic and Analgesic Considerations
Fanelli, D., Weller, G. E. R., & Liu, H. (2021) · Neurology International · doi:10.3390/neurolint13040049 · Cited by 62 · see citing works
Neuropathic cancer pain: What we are dealing with? How to manage it?
Yalçın, Ş., & Esin, E. (2014) · OncoTargets and Therapy · doi:10.2147/ott.s60995 · Cited by 62 · see citing works
A Review of Postoperative Analgesia for Breast Cancer Surgery
Cheng, G. S., & Ilfeld, B. M. (2016) · Pain Management · doi:10.2217/pmt-2015-0008 · Cited by 58 · see citing works
The Effects of Anesthetics on Chronic Pain After Breast Cancer Surgery
Cho, A.-R., Kwon, J.-Y., Kim, K.-H., Lee, H. J., Kim, H.-K., Kim, E., Hong, J.-M., & Kim, C. (2013) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31827ee372 · Cited by 57 · see citing works
Perioperative Interventions to Reduce Chronic Postsurgical Pain
Hah, J. M., Mackey, S., Ottestad, E., Kong, J., Lahidji, S., Tawfik, V. L., Younger, J., Curtin, C. M., & Carroll, I. R. (2013) · Journal of Reconstructive Microsurgery · doi:10.1055/s-0032-1329921 · Cited by 56 · see citing works
Oliveira, G. D. D., Chang, R., Khan, S., Hansen, N., Khan, J. H., McCarthy, R. J., & Apkarian, A. (2014) · The Breast Journal · doi:10.1111/tbj.12207 · Cited by 53 · see citing works
Nursing’s Role in Cancer Pain Management
Vallerand, A. H., Musto, S., & Polomano, R. C. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-011-0203-5 · Cited by 53 · see citing works
Yan, P. Z., Butler, P. M., Kurowski, D., & Perloff, M. D. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000014 · Cited by 49 · see citing works
“Post Mastectomy Pain Syndrome: A Systematic Review of Prevention Modalities”
Yuksel, S. S., Chappell, A. G., Jackson, B., Wescott, A., & Ellis, M. F. (2021) · JPRAS Open · doi:10.1016/j.jpra.2021.10.009 · Cited by 50 · see citing works
Cheng, G. S., & Ilfeld, B. M. (2016) · Pain Medicine · doi:10.1093/pm/pnw172 · Cited by 47 · see citing works
Paul, J., Nantha-Aree, M., Buckley, N., Shahzad, U., Cheng, J., Thabane, L., Tidy, A., DeBeer, J., Winemaker, M., Wismer, D., et al. (2015) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-014-0310-y · Cited by 46 · see citing works
Kendall, M. C., McCarthy, R. J., Panaro, S., Goodwin, E. J., Bialek, J. M., Nader, A., & Oliveira, G. S. D. (2017) · Pain Practice · doi:10.1111/papr.12611 · Cited by 44 · see citing works
Brenin, D. R., Dietz, J. R., Baima, J. A., Cheng, G. S., Froman, J. P., Laronga, C., Ma, A., Manahan, M. A., Mariano, E. R., Rojas, K. E., et al. (2020) · Annals of Surgical Oncology · doi:10.1245/s10434-020-08892-x · Cited by 46 · see citing works
Jiang, Y., Li, J., Lin, H., Huang, Q., Wang, T., Zhang, S., Zhang, Q., Rong, Z., & Xiong, J. (2018) · Medicine · doi:10.1097/md.0000000000011581 · Cited by 41 · see citing works
Watson, P. N. C., Gilron, I., Sawynok, J., & Lynch, M. E. (2011) · Pain · doi:10.1016/j.pain.2011.05.032 · Cited by 37 · see citing works
Utilization and effectiveness of multimodal discharge analgesia for postoperative pain management
Desai, K. R., Carroll, I. R., Asch, S. M., Seto, T., McDonald, K. M., Curtin, C. M., & Hernandez‐Boussard, T. (2018) · Journal of Surgical Research · doi:10.1016/j.jss.2018.03.029 · Cited by 36 · see citing works
Ludwig, K. K., Wexelman, B. A., Chen, S., Cheng, G. S., DeSnyder, S. M., Golesorkhi, N., Greenup, R. A., James, T. A., Lee, B. T., Pockaj, B. A., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-11799-4 · Cited by 35 · see citing works
Ebid, A., & El-Sodany, A. M. (2015) · Lasers in Medical Science · doi:10.1007/s10103-015-1780-z · Cited by 38 · see citing works
Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations
Gewandter, J. S., Dworkin, R. H., Turk, D. C., Farrar, J. T., Fillingim, R. B., Gilron, I., Markman, J. D., Oaklander, A. L., Polydefkis, M. J., Raja, S. N., et al. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000895 · Cited by 34 · see citing works
Effects of Gabapentin on Pain and Opioid Consumption after Abdominal Hysterectomy
Frouzanfard, F., Fazel, M. R., Abolhasani, A., Fakharian, E., Mousavi, G., & Moravveji, A. (2013) · Pain Research and Management · doi:10.1155/2013/787401 · Cited by 32 · see citing works
Deconstructing Postmastectomy Syndrome
Wisotzky, E. M., Hanrahan, N. F., Lione, T. P., & Maltser, S. (2016) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2016.09.003 · Cited by 32 · see citing works
Amin, S., & Amr, Y. (2011) · Anesthesia Essays and Researches · doi:10.4103/0259-1162.94758 · Cited by 32 · see citing works
Self-citationFabritius, M. L., Geisler, A. E., Petersen, P. L., Wetterslev, J., Mathiesen, O., & Dahl, J. B. (2017) · BMC Anesthesiology · doi:10.1186/s12871-017-0373-8 · Cited by 31 · see citing works
Wang, L., Tobe, J., Au, E., Tran, C., Jomy, J., Oparin, Y., Couban, R., & Paul, J. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.08.032 · Cited by 28 · see citing works
Diagnosis, Treatment, and Management of Painful Scar: A Narrative Review
Abd-Elsayed, A., Pope, J., Mundey, D. A., Slavin, K. V., Falowski, S. M., Chitneni, A., Popielarski, S. R., John, J., Grodofsky, S., Vanetesse, T., et al. (2022) · Journal of Pain Research · doi:10.2147/jpr.s355096 · Cited by 30 · see citing works
Cancer Treatment-Related Neuropathic Pain Syndromes—Epidemiology and Treatment: An Update
Smith, E. M. L., Bridges, C. M., Kanzawa-Lee, G. A., Knoerl, R., Kelly, J. P., Berezovsky, A., & Woo, C. (2014) · Current Pain and Headache Reports · doi:10.1007/s11916-014-0459-7 · Cited by 29 · see citing works
Post-Breast Surgery Pain Syndrome: Shifting a Surgical Paradigm
Beederman, M. R., & Bank, J. (2021) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000003720 · Cited by 29 · see citing works
Amaya, F., Hosokawa, T., Okamoto, A., Matsuda, M., Yamaguchi, Y., Yamakita, S., Taguchi, T., & Sawa, T. (2015) · BioMed Research International · doi:10.1155/2015/641508 · Cited by 28 · see citing works
Scheinfeld, N. S. (2013) · Dermatology Online Journal · doi:10.5070/d31911020616 · Cited by 28 · see citing works
Psychiatric agents and implications for perioperative analgesia
Catalani, B., Hamilton, C. S., Herron, E. W., Urman, R. D., Fox, C. J., & Kaye, A. D. (2014) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2014.05.001 · Cited by 26 · see citing works
Enhanced Recovery After Surgery Pathways in Breast Reconstruction
Persing, S. M., Manahan, M. A., & Rosson, G. D. (2020) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2019.12.002 · Cited by 26 · see citing works
The efficacy of gabapentin combined with opioids for neuropathic cancer pain: a meta-analysis
Bao, H., Wu, Z., Wang, Q., Wang, J., Zhang, L., Meng, L., & Han, F. (2021) · Translational Cancer Research · doi:10.21037/tcr-20-2692 · Cited by 25 · see citing works
Fabritius, M. L., Wetterslev, J., Mathiesen, O., & Dahl, J. B. (2017) · Journal of Pain Research · doi:10.2147/jpr.s138519 · Cited by 24 · see citing works
Schnabel, A., Weibel, S., Reichl, S. U., Meißner, M., Kranke, P., Zahn, P. K., Pogatzki-Zahn, E. M., & Meyer‐Frießem, C. H. (2021) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2021.110451 · Cited by 25 · see citing works
Alkan, A., Güç, Z. G., Şenler, F. Ç., Yavuzşen, T., Onur, H., Doğan, M., Karcı, E., Yaşar, A., Köksoy, E. B., Tanrıverdi, Ö., et al. (2016) · Supportive Care in Cancer · doi:10.1007/s00520-016-3202-6 · Cited by 24 · see citing works
Salvat, É., Yalçın, İ., Muller, A., & Barrot, M. (2017) · Molecular Pain · doi:10.1177/1744806917749683 · Cited by 23 · see citing works
Chen, V. E., Greenberger, B. A., Shi, Z., Gajjar, S. R., Shi, W., Mourad, W. F., & Yan, W. (2020) · Translational Cancer Research · doi:10.21037/tcr.2019.06.46 · Cited by 23 · see citing works
Diagnosis, Treatment, and Management of Painful Scar: A Narrative Review
Abd-Elsayed, A. A., Pope, J. E., Mundey, D. A., Slavin, K. V., Falowski, S. M., Chitneni, A., Popielarski, S. R., John, J., Grodofsky, S., Vanetesse, T., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 22 · see citing works
Enhanced Recovery After Surgery: Opioid Sparing Strategies After Discharge: A Review
Rajput, K., Shergill, S., Chow, R. M., Vadivelu, N., & Kaye, A. D. (2022) · Current Pain and Headache Reports · doi:10.1007/s11916-022-01009-x · Cited by 21 · see citing works
New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review
Mayoral, V., Charaja, M., Casasola, O. D. L., Montero, A., Tamayo, M. A. N., & Varrassi, G. (2022) · Cureus · doi:10.7759/cureus.23037 · Cited by 22 · see citing works
Postmastectomy Pain Syndrome: A Narrative Review
Salati, S. A., AlSulaim, L. S., Alharbi, M. H., Alharbi, N., Alsenaid, T. M., Alaodah, S. A., Alsuhaibani, A. S., & Albaqami, K. A. (2023) · Cureus · doi:10.7759/cureus.47384 · Cited by 25 · see citing works
Efficacy of perioperative duloxetine on acute and chronic postmastectomy pain
Nasr, D. A. M. (2014) · Ain-Shams Journal of Anaesthesiology · doi:10.4103/1687-7934.133345 · Cited by 21 · see citing works
Arora, V. K., Morado-Urbina, C. E., Aschenbrenner, C. A., Hayashida, K., Wang, F., Martin, T. J., Eisenach, J. C., & Peters, C. M. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.10.009 · Cited by 21 · see citing works
Berger, J. M., Longhitano, Y., Zanza, C., & Sener, S. F. (2020) · Journal of Surgical Oncology · doi:10.1002/jso.26176 · Cited by 21 · see citing works
Ye, Y., Gabriel, R. A., & Mariano, E. R. (2021) · Postgraduate Medicine · doi:10.1080/00325481.2021.1935281 · Cited by 19 · see citing works
Patel, S. Y., Getting, R. E. G., Alford, B., Hussein, K., Schaible, B., Boulware, D. C., Lee, J. K., Gilbert, S. M., Pow‐Sang, J. M., Sexton, W. J., et al. (2018) · World Journal of Surgery · doi:10.1007/s00268-018-4665-z · Cited by 19 · see citing works
Pollak, U., Bronicki, R. A., Achuff, B.-J., & Checchia, P. A. (2019) · Journal of Intensive Care Medicine · doi:10.1177/0885066619871432 · Cited by 18 · see citing works
Effect of perioperative intravenous flurbiprofen axetil on chronic postmastectomy pain.
Sun, M., Liao, Q., Wen, L., Yan, X., Zhang, F., & Ouyang, W. (2013) · PubMed · doi:10.3969/j.issn.1672-7347.2013.07.001 · Cited by 18 · see citing works
Staurengo‐Ferrari, L., Bonet, I. J. M., Araldi, D., Green, P. G., & Levine, J. D. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1691-21.2021 · Cited by 17 · see citing works
Eloy, J. D., Anthony, C., Amin, S., Caparo, M. A., Reilly, M. C., & Shulman, S. M. (2017) · Pain Research and Management · doi:10.1155/2017/2310382 · Cited by 17 · see citing works
Perioperative Pregabalin for Preventive Analgesia in Breast Cancer Surgery
Chang, C.-C., Yen, W.-T., Lin, Y., Wang, L., Hung, K., Wu, Z., & Chen, J. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000883 · Cited by 17 · see citing works
Lepot, A., Elia, N., Tramèr, M. R., & Rehberg, B. (2021) · European Journal of Pain · doi:10.1002/ejp.1648 · Cited by 16 · see citing works
Impact of Perioperative Hypnosedation on Postmastectomy Chronic Pain: Preliminary Results
Lacroix, C., Duhoux, F. P., Bettendorff, J., Watremez, C., Roelants, F., Docquier, M.-A., Potié, A., Coyette, M., Gerday, A., Samartzi, V., et al. (2019) · Integrative Cancer Therapies · doi:10.1177/1534735419869494 · Cited by 16 · see citing works
Avoid Postoperative Pain To Prevent Its Chronification: A Narrative Review
Matamala, A. M., Hanna, M., Perrot, S., & Varrassi, G. (2022) · Cureus · doi:10.7759/cureus.22243 · Cited by 18 · see citing works
Interventions to Alleviate Symptoms Related to Breast Cancer Treatments and Areas of Needed Research
Janelsins, M. C., Mustian, K. M., Peppone, L. J., & Sprod, L. K. (2011) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.s2-001 · Cited by 15 · see citing works
Persistent Pain After Breast Cancer Surgery in a Chinese Population
Li, Y. Y. O., & Kong, S. K. (2011) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31820e12b1 · Cited by 14 · see citing works
Kaur, N., Kumar, A., Saxena, A. K., Gupta, A., & Grover, R. K. (2017) · Indian Journal of Surgery · doi:10.1007/s12262-017-1663-6 · Cited by 16 · see citing works
Motaghinejad, M., Ebrahimzadeh, A., & Shabab, B. (2014) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
Kraft, C. T., O’Brien, A. L., & Skoracki, R. J. (2019) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000002070 · Cited by 14 · see citing works
Bešič, N., Smrekar, J., & Stražišar, B. (2020) · Scientific Reports · doi:10.1038/s41598-020-75961-2 · Cited by 14 · see citing works
Chronic pain following breast surgery
Brummett, C. M. (2011) · Techniques in Regional Anesthesia and Pain Management · doi:10.1053/j.trap.2011.07.001 · Cited by 14 · see citing works
Antidepressant Drugs for Postsurgical Pain: Current Status and Future Directions
Gilron, I. (2016) · Drugs · doi:10.1007/s40265-015-0517-4 · Cited by 13 · see citing works
Nori, P., Kline‐Quiroz, C. M., & Stubblefield, M. D. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2019.10.005 · Cited by 11 · see citing works
A Review of Adjunctive CNS Medications Used for the Treatment of Post-Surgical Pain
Rai, A., Meng, H., Weinrib, A., Englesakis, M. F., Kumbhare, D. A., Grosman‐Rimon, L., Katz, J. D., & Clarke, H. A. (2017) · CNS Drugs · doi:10.1007/s40263-017-0440-1 · Cited by 11 · see citing works
Moulder, J. K., Boone, J. D., Buehler, J. M., & Louie, M. (2018) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000410 · Cited by 11 · see citing works
de Liyis, B. G., Sutedja, J. C., Tjandra, D. C., Putri, N. L. P. S. W., Gunawan, M. F. B., Karuniamaya, C. P., Barus, J., Pinzon, R. T., & Widyadharma, I. P. E. (2024) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2024.108223 · Cited by 10 · see citing works
- Authors
- Amr, Y. M., & Yousef, A. A. A.-M.
- Affiliations
- Tanta University (EG)
- Venue
- The Clinical Journal of Pain
- Published
- 2010-06
- Volume
- 26
- Issue
- 5
- Pages
- 381-385
- ISSN
- 0749-8047 (ISSN-L)
- OpenAlex
- W2015932657
- Cited by
- 173
- References
- 27
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 13 · 2020: 12 · 2019: 6 · 2018: 14 · 2017: 18 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 17 · 2012: 2
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2025-09-01)
- Open access
- closed
- Locations
- Clinical Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- post-mastectomy pain syndrome, venlafaxine, gabapentin, preemptive analgesia, perioperative analgesia, breast cancer surgery, mastectomy, axillary lymph node dissection, neuropathic pain, chronic postoperative pain, burning pain, opioid consumption, analgesic requirement
- MeSH terms
- Venlafaxine Hydrochloride, Gabapentin, Acute Disease, Adult, Amines, Analgesics, Breast Neoplasms, Chronic Disease, Cyclohexanecarboxylic Acids, Cyclohexanols, Female, gamma-Aminobutyric Acid, Humans, Middle Aged, Morphine, Pain Measurement, Postoperative Pain, Mastectomy, Radical, Mastectomy, Segmental, Treatment Outcome, Statistics, Nonparametric, Perioperative Care
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
