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Cited by 186Anesthesia and Pain ManagementCancer, Stress, Anesthesia, and Immune ResponsePain Management and Opioid Use

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Perioperative Intravenous Lidocaine Decreases the Incidence of Persistent Pain After Breast Surgery

Grigoras, Anca, Lee, Peter, Sattar, Faisal, Shorten, George·2012·The Clinical Journal of Pain
DOI 10.1097/ajp.0b013e31823b9cc8
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Abstract

OBJECTIVES: Breast cancer surgery is associated with a high incidence of persistent postsurgical pain (PPSP). The aim of this study was to evaluate the impact of intravenous (IV) lidocaine on acute and PPSP, analgesic requirements, and sensation abnormalities in patients undergoing surgery for breast cancer. METHODS: Thirty-six patients participated in this randomized, double-blinded study. Before induction of general anesthesia, patients received a bolus of intravenous lidocaine 1.5 mg/kg followed by a continuous infusion of lidocaine 1.5 mg/kgh (lidocaine group) or an equal volume of saline (control group). The infusion was stopped 1 hour after the skin closure. Pain scores and analgesic consumption were recorded at 2, 4, 24 hours, and then daily for 1 week postoperatively. Three months later, patients were assessed for PPSP and secondary hyperalgesia. RESULTS: Two (11.8%) patients in the lidocaine group and 9 (47.4%) patients in the control group reported PPSP at 3 months follow-up (P=0.031). McGill Pain Questionnaire revealed greater present pain intensity-visual analog scale in the control group (14.6 ± 22.5 vs. 2.6 ± 7.5; P=0.025). Secondary hyperalgesia (area of hyperalgesia/length of surgical incision) was significantly less in the lidocaine group compared with control group (0.2 ± 0.8 vs. 3.2 ± 4.5 cm; P=0.002). The 2 groups were similar in terms of analgesic consumption during the early postoperative period. DISCUSSION: Intravenous perioperative lidocaine decreases the incidence and severity of PPSP after breast cancer surgery. Prevention of the induction of central hyperalgesia is a potential mechanism.

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Crossref · 10.1097/ajp.0b013e31823b9cc8

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  1. Bennett, 1995, Lidocaine in the management of primary fibromyalgia syndrome., Int J Clin Pharmacol Res, 15, 115

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Metadata

Authors
Grigoras, A., Lee, P., Sattar, F., & Shorten, G.
Affiliations
University College Cork (IE)
ORCID
Venue
The Clinical Journal of Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-09
Volume
28
Issue
7
Pages
567-572
ISSN
0749-8047 (ISSN-L)
DOI
10.1097/ajp.0b013e31823b9cc8
OpenAlex
W2059055540
Cited by
186
References
38
Citations by year
2026: 7 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 11 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 17 · 2017: 20 · 2016: 15 · 2015: 19 · 2014: 16 · 2013: 24 · 2012: 4
FWCI
20.52
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Journal of Pain (publishedVersion)
  • PubMed (publishedVersion)
  • Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
intravenous lidocaine, chronic postoperative pain, breast cancer surgery, perioperative analgesia, secondary hyperalgesia, analgesic use, postoperative pain prevention
MeSH terms
Adult, Aged, Anesthetics, Local, Back Pain, Breast Neoplasms, Chronic Disease, Double-Blind Method, Drug Administration Schedule, Female, Humans, Hyperalgesia, Lidocaine, Middle Aged, Pain, Pain Measurement, Postoperative Complications, Prospective Studies, Time Factors, Incidence, Administration, Intravenous

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