The DOI matches its Crossref record; 71 of the 72 references it cites were found in a registry or an index.
Does Mobilization of the Upper Cervical Spine Affect Pain Sensitivity and Autonomic Nervous System Function in Patients With Cervico-craniofacial Pain?: A Randomized-controlled Trial
Abstract
Objectives The aims were to investigate the effects of anterior-posterior upper cervical mobilization (APUCM) on pain modulation in craniofacial and cervical regions and its influence on the sympathetic nervous system. Methods Thirty-two patients with cervico-craniofacial pain of myofascial origin were randomly allocated into experimental or placebo groups. Each patient received 3 treatments. Outcome measures included bilateral pressure pain thresholds assessed at craniofacial and cervical points preintervention, after the second intervention and after the final treatment. Pain intensity and sympathetic nervous system variables (skin conductance, breathing rate, heart rate, and skin temperature) were assessed before and immediately after each intervention. Results The pressure pain thresholds in the craniofacial and cervical regions significantly increased (P Discussion This study provided preliminary evidence of a short-term hypoalgesic effect of APUCM on craniofacial and cervical regions of patients with cervico-craniofacial pain of myofascial origin, suggesting that APUCM may cause an immediate nociceptive modulation in the trigeminocervical complex. We also observed a sympathoexcitatory response, which could be related to the hypoalgesic effect induced by the technique, but this aspect should be confirmed in future studies.
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In the citing paper
“Only 6 studies accomplished more than 60% of the items listed in eTable 2. 57,66,67, 76 -78”
From Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis (2016) · cites this paper as [67]
In the citing paper
“A recent RCT conducted by La Touche et al 67 testing a more specific approach directed to the cervical spine to treat patients with cervico-craniofacial pain of myofascial origin was performed.”
From Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis (2016) · cites this paper as [67]
In the citing paper
“Eight of the trials 57,65,67,74,75,77,87,88 reported no adverse events with the treatments.”
From Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis (2016) · cites this paper as [67]
In the citing paper
“Publication bias was difficult to determine visually (figure 3B) and could not be quantified using Egger regression because of the small number of trials.44,45”
In the citing paper
“Compared with sham intervention, MT did not significantly increase PPT of the masseter (MD: 0.45 kg/cm2, 95% CI: -0.21 to 1.11, P=.18; figure 5A)38,44,45 or temporalis muscle (MD: 0.37 kg/cm2, 95% CI: -0.03 to 0.77, P=.07; figure 6A).38,44, 45, 46”
In the citing paper
“Compared with sham intervention, MT did not significantly increase PPT of the masseter (MD: 0.45 kg/cm2, 95% CI: -0.21 to 1.11, P=.18; figure 5A)38,44,45 or temporalis muscle (MD: 0.37 kg/cm2, 95% CI: -0.03 to 0.77, P=.07; figure 6A).38,44, 45, 46”
Citations
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Travell, J. G., & Simons, D. G. (1982) · Medical Entomology and Zoology · Cited by 2,735
Reliability of the Visual Analog Scale for Measurement of Acute Pain
Bijur, P. E., Silver, W. G., & Gallagher, E. J. (2001) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2001.tb01132.x · Cited by 2,091
Clinical Significance of Reported Changes in Pain Severity☆☆☆★
Todd, K. H., Funk, K. G., Funk, J. P., & Bonacci, R. P. (1996) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(96)70238-x · Cited by 1,110
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Chesterton, L. S., Sim, J., Wright, C. C., & Foster, N. E. (2007) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318154b6ae · Cited by 690
Bartsch, T. (2002) · Brain · doi:10.1093/brain/awf166 · Cited by 475
Sterling, M. M., Jull, G. A., & Wright, A. (2001) · Manual Therapy · doi:10.1054/math.2000.0378 · Cited by 431
Pfaller, K., & Arvidsson, J. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902680110 · Cited by 423
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1 of the 72 references couldn’t be matched to a known paper.
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Armijo-Olivo, S., Pitance, L., Singh, V., Neto, F., Thie, N., & Michelotti, A. (2016) · Physical Therapy · doi:10.2522/ptj.20140548 · Cited by 413
Management of pain in patients with temporomandibular disorder (TMD): challenges and solutions
Gil‐Martínez, A., Paris‐Alemany, A., López‐de‐Uralde‐Villanueva, I., & Touche, R. L. (2018) · Journal of Pain Research · doi:10.2147/jpr.s127950 · Cited by 331
Calixtre, L. B., Moreira, R. F. C., Franchini, G. H., Alburquerque‐Sendín, F., & Oliveira, A. B. (2015) · Journal of Oral Rehabilitation · doi:10.1111/joor.12321 · Cited by 195
Mechanism of Action of Spinal Mobilizations
Lascurain‐Aguirrebeña, I., Newham, D. J., & Critchley, D. (2016) · Spine · doi:10.1097/brs.0000000000001151 · Cited by 125
Beltran-Alacreu, H., López-de-Uralde-Villanueva, I., Fernández-Carnero, J., & La Touche, R. (2015) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000293 · Cited by 107
Self-citation
Metadata
- Authors
- La Touche, R., París-Alemany, A., Mannheimer, J. S., Angulo-Díaz-Parreño, S., Bishop, M. D., Lopéz-Valverde-Centeno, A., von Piekartz, H., & Fernández-Carnero, J.
- Affiliations
- Columbia University (US)
- University of Florida Health (US)
- Universidad Europea de Madrid (ES)
- Venue
- The Clinical Journal of Pain
- Published
- 2013-03
- Volume
- 29
- Issue
- 3
- Pages
- 205-215
- ISSN
- 0749-8047 (ISSN-L)
- OpenAlex
- W2156862303
- Cited by
- 112
- References
- 72
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 12 · 2022: 7 · 2021: 6 · 2020: 16 · 2019: 12 · 2018: 13 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 3 · 2013: 2
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Myofascial pain diagnosis and treatment
- Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- myofascial pain, pain modulation, pressure pain threshold, sympathetic nervous system, skin conductance, trigeminocervical complex, hypoalgesia, cervical manipulation
- MeSH terms
- Adult, Autonomic Nervous System, Cervical Vertebrae, Facial Pain, Female, Heart Rate, Humans, Male, Skin Temperature, Spain, Respiratory Mechanics, Treatment Outcome, Musculoskeletal Manipulations, Pain Perception
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