The DOI matches its Crossref record, with a small difference in title or year; 47 of the 47 references it cites were found in a registry or an index.
Opioid Abuse and Dependence during Pregnancy: Temporal Trends and Obstetrical Outcomes
Open accessAbstract
Background: The authors investigated nationwide trends in opioid abuse or dependence during pregnancy and assessed the impact on maternal and obstetrical outcomes in the United States. Methods: Hospitalizations for delivery were extracted from the Nationwide Inpatient Sample from 1998 to 2011. Temporal trends were assessed and logistic regression was used to examine the associations between maternal opioid abuse or dependence and obstetrical outcomes adjusting for relevant confounders. Results: The prevalence of opioid abuse or dependence during pregnancy increased from 0.17% (1998) to 0.39% (2011) for an increase of 127%. Deliveries associated with maternal opioid abuse or dependence compared with those without opioid abuse or dependence were associated with an increased odds of maternal death during hospitalization (adjusted odds ratio [aOR], 4.6; 95% CI, 1.8 to 12.1, crude incidence 0.03 vs. 0.006%), cardiac arrest (aOR, 3.6; 95% CI, 1.4 to 9.1; 0.04 vs. 0.01%), intrauterine growth restriction (aOR, 2.7; 95% CI, 2.4 to 2.9; 6.8 vs. 2.1%), placental abruption (aOR, 2.4; 95% CI, 2.1 to 2.6; 3.8 vs. 1.1%), length of stay more than 7 days (aOR, 2.2; 95% CI, 2.0 to 2.5; 3.0 vs. 1.2%), preterm labor (aOR, 2.1; 95% CI, 2.0 to 2.3; 17.3 vs. 7.4%), oligohydramnios (aOR, 1.7; 95% CI, 1.6 to 1.9; 4.5 vs. 2.8%), transfusion (aOR, 1.7; 95% CI, 1.5 to 1.9; 2.0 vs. 1.0%), stillbirth (aOR, 1.5; 95% CI, 1.3 to 1.8; 1.2 vs. 0.6%), premature rupture of membranes (aOR, 1.4; 95% CI, 1.3 to 1.6; 5.7 vs. 3.8%), and cesarean delivery (aOR, 1.2; 95% CI, 1.1 to 1.3; 36.3 vs. 33.1%). Conclusions: Opioid abuse or dependence during pregnancy is associated with considerable obstetrical morbidity and mortality, and its prevalence is dramatically increasing in the United States. Identifying preventive strategies and therapeutic interventions in pregnant women who abuse drugs are important priorities for clinicians and scientists.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“with a particular increase observed for opiate use during pregnancy (127% increase from 1998 to 2011) [10]”
From Written exposure therapy for treatment of perinatal PTSD among women with comorbid PTSD and SUD: A pilot study examining feasibility, acceptability, and preliminary effectiveness (2023) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Substance use during pregnancy is increasing [10]”
From Written exposure therapy for treatment of perinatal PTSD among women with comorbid PTSD and SUD: A pilot study examining feasibility, acceptability, and preliminary effectiveness (2023) · cites this paper as [10]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Vital signs: overdoses of prescription opioid pain relievers---United States, 1999--2008.
Paulozzi, L. J., Jones, C. M., Mack, K. A., & Rudd, R. A. (2011) · PubMed · Cited by 1,350
Neonatal Abstinence Syndrome and Associated Health Care Expenditures: United States, 2000-2009
Patrick, S. W., Schumacher, R. E., Benneyworth, B. D., Krans, E. E., McAllister, J. M., & Davis, M. M. (2012) · JAMA · doi:10.1001/jama.2012.3951 · Cited by 907
Major increases in opioid analgesic abuse in the United States: Concerns and strategies
Compton, W. M., & Volkow, N. D. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.05.009 · Cited by 824
Opioids and the control of respiration
Pattinson, K. T. S. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen094 · Cited by 794
Indications Contributing to the Increasing Cesarean Delivery Rate
Barber, E. L., Lundsberg, L. S., Belanger, K. D., Pettker, C. M., Funai, E. F., & Illuzzi, J. L. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31821e5f65 · Cited by 694
Contemporary cesarean delivery practice in the united states
Zhang, J., Troendle, J., Reddy, U. M., Laughon, S. K., Branch, D. W., Burkman, R., Landy, H. J., Hibbard, J. U., Haberman, S., Ramirez, M. M., et al. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.06.058 · Cited by 576
Kuklina, E. V., Whiteman, M. K., Hillis, S. D., Jamieson, D. J., Meikle, S., Posner, S. F., & Marchbanks, P. A. (2007) · Maternal and Child Health Journal · doi:10.1007/s10995-007-0256-6 · Cited by 479
Cesarean Birth in the United States: Epidemiology, Trends, and Outcomes
MacDorman, M. F., Menacker, F., & Declercq, E. R. (2008) · Clinics in Perinatology · doi:10.1016/j.clp.2008.03.007 · Cited by 468
Neonatal Abstinence Syndrome and Associated Health Care Expenditures
Patrick, S. W., Schumacher, R. E., Benneyworth, B. D., Krans, E. E., McAllister, J. M., & Davis, M. M. (2013) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000429117.48176.cc · Cited by 454
Flagged first, then by citations
Research works printed but not linked: 1
- 2006, Major increases in opioid analgesic abuse in the United States: Concerns and strategies., Drug Alcohol Depend, 81, 103, 10.1016/j.drugalcdep.2005.05.009 · DOI
Cited by
Sorted by citations
Fatal and nonfatal overdose among pregnant and postpartum women in Massachusetts
Schiff, D. M., Nielsen, T., Terplan, M., Hood, M., Bernson, D., Diop, H., Bharel, M., Wilens, T. E., LaRochelle, M., Walley, A. Y., et al. (2018) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000002734 · Cited by 327
Nillni, Y. I., Baul, T. D., Paul, E., Godfrey, L. B., Sloan, D. M., & Valentine, S. E. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.04.013 · Cited by 28
Corsi, D. J., & Murphy, M. S. Q. (2021) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13577 · Cited by 17
Metadata
- Authors
- Maeda, A., Bateman, B. T., Clancy, C. R., Creanga, A. A., & Leffert, L. R.
- Affiliations
- Massachusetts General Hospital (US)
- Brigham and Women's Hospital (US)
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Leffert, Lisa R.
- Venue
- Anesthesiology
- Published
- 2014-12
- Volume
- 121
- Issue
- 6
- Pages
- 1158-1165
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2009000630
- Cited by
- 317
- References
- 47
- Citations by year
- 2026: 12 · 2025: 26 · 2024: 27 · 2023: 27 · 2022: 30 · 2021: 46 · 2020: 45 · 2019: 38 · 2018: 27 · 2017: 21 · 2016: 5 · 2015: 11 · 2014: 2
- FWCI
- 12.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- opioid use during pregnancy, maternal opioid dependence, maternal mortality, pregnancy complications, preterm labor, fetal growth restriction, placental abruption, stillbirth, neonatal abstinence syndrome, neonatal intensive care, neonatal mortality, temporal trends, hospitalization outcomes, United States, National Inpatient Sample, opioid epidemic, maternal health policy, prenatal care access, substance use disorders
- MeSH terms
- Adolescent, Adult, Female, Humans, Insurance, Health, Obstetric Labor Complications, Maternal Mortality, Opioid-Related Disorders, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Socioeconomic Factors, United States, Prevalence, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
