Cited by 496Anesthesia and Neurotoxicity ResearchAnesthesia and Sedative AgentsMemory and Neural Mechanisms

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Neonatal Exposure to Sevoflurane Induces Abnormal Social Behaviors and Deficits in Fear Conditioning in Mice

Open access

Satomoto, Maiko, Satoh, Yasushi, Terui, Katsuo, Miyao, Hideki, Takishima, Kunio, Ito, Masataka, Imaki, Junko·2009·Anesthesiology

DOI 10.1097/aln.0b013e3181974fa2

Open this paper in CoChat — free account Open PDF

Abstract

Background: Neonatal exposure to anesthetics that block N-methyl-D-aspartate receptors and/or hyperactivate gamma-aminobutyric acid type A receptor has been shown to cause neuronal degeneration in the developing brain, leading to functional deficits later in adulthood. The authors investigated whether exposure of neonatal mice to inhaled sevoflurane causes deficits in social behavior as well as learning disabilities. Methods: Six-day-old C57BL/6 mice were exposed to 3% sevoflurane for 6 h. Activated cleaved caspase-3 immunohistochemical staining was used for detection of apoptosis. Cognitive functions were tested by pavlovian conditioned fear test. Social behavior was tested by social recognition and interaction tests. Results: Neonatal exposure to sevoflurane significantly increased the number of apoptotic cells in the brain immediately after anesthesia. It caused persistent learning deficits later in adulthood as evidenced by decreased freezing response in both contextual and cued fear conditioning. The social recognition test demonstrated that mice with neonatal exposure to sevoflurane did not develop social memory. Furthermore, these mice showed decreased interactions with a social target compared with controls in the social interaction test, indicating a social interaction deficit. The authors did not attribute these abnormalities in social behavior to impairments of general interest in novelty or olfactory sensation, because they did not detect significant differences in the test for novel inanimate object interaction or for olfaction. Conclusions: This study shows that exposure of neonatal mice to inhaled sevoflurane could cause not only learning deficits but also abnormal social behaviors resembling autism spectrum disorder.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1097/aln.0b013e3181974fa2

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Rice, D., & Barone, S. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3511 · Cited by 2,944
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., & Earnshaw, W. C. (1994) · Nature · doi:10.1038/371346a0 · Cited by 2,563
Comparative aspects of the brain growth spurt
Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Neural synchrony in brain disorders: Relevance for cognitive dysfunctions and pathophysiology
Uhlhaas, P. J., & Singer, W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.020 · Cited by 2,194
Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits
Jevtovic-Todorovic, V., Hartman, R. E., Izumi, Y., Benshoff, N. D., Dikranian, K., Zorumski, C. F., Olney, J. W., & Wozniak, D. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00876.2003 · Cited by 1,983
Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome
Ikonomidou, C., Bittigau, P., Ishimaru, M. J., Wozniak, D. F., Koch, C. A., Genz, K., Price, M. T., Stefovska, V. G., Hörster, F., Tenkova, T., et al. (2000) · Science · doi:10.1126/science.287.5455.1056 · Cited by 1,382

Show all 31 references

Sorted by citations

Items 401–494 of 494

Protective effects of TRPV1 inhibition against sevoflurane-induced cell death
Liu, Y., Yang, H., Sun, C., Wang, Z., & Liu, Z. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.05.024 · Cited by 4
Kapβ2 Inhibits Perioperative Neurocognitive Disorders in Rats with Mild Cognitive Impairment by Reversing the Nuclear-Cytoplasmic Mislocalization of hnRNPA2/B1
Zhang, M., Jia, F., Wang, Q., Yang, C., Wang, X., Liu, T., Tang, Q., Yang, Z. R., & Wang, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03789-8 · Cited by 4
Effects of sevoflurane and clonidine on acid base status and long-term emotional and cognitive outcomes in spontaneously breathing rat pups
Almenräder, N., Colucci, P., Castro, V. D., Valeri, D., Palmery, M., Trezza, V., & Campolongo, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173969 · Cited by 4
Sevoflurane induces endoplasmic reticulum stress mediated apoptosis inmouse hippocampal neuronal HT22 cells via modulating miR-15b-5p/Rab1A signaling pathway.
Li, Y., Xia, H., Chen, L., & Zhang, X. (2017) · PubMed Central · Cited by 4
Interval-dependent neurotoxicity after multiple ketamine injections in late postnatal mice
Lee, Y., Youn, A. M., Ju, X., Cui, J., Hong, B., Yun, S., Ko, Y., Kim, Y. H., Heo, J. Y., & Chung, W. (2020) · Journal of Anesthesia · doi:10.1007/s00540-020-02876-7 · Cited by 4
Sevoflurane Impairs Growth Cone Motility in Dissociated Murine Neurons
Ryu, Y. K., Mathena, R. P., Lim, S., Kwak, M., Xu, M., & Mintz, C. D. (2016) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0000000000000360 · Cited by 4
EXPERIMENTAL SIMULATION OF POST-OPERATIVE COGNITIVE DISORDERS IN RATS
Владимировна, Б. И., Драволина, О. А., Krivov, V. O., Tur, M. А., & Polushin, Y. S. (2016) · Messenger of Anesthesiology and Resuscitation · doi:10.21292/2078-5658-2016-13-5-37-49 · Cited by 4
Anesthetic Exposure in Staged Versus Single-Stage Cleft Lip and Palate Repair: Can We Reduce Risk of Anesthesia-Induced Developmental Neurotoxicity?
Davila, A. A., Holzmer, S. W., Kubiak, J., & Martin, M. C. (2020) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000007156 · Cited by 4
Comprehensive characterization of chronic midazolam exposure on neonates and long-term neurodevelopment
Nguyen, N. M., Athota, P., Flores, A., Trease, A. J., Meyer, D., Singu, V. K., Krishnamoorthy, C., Schaal, V. L., Bhakat, R., Sualy, K., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03104-y · Cited by 3
Anesthetic Exposure During Early Childhood and Neurodevelopmental Outcomes: Our Current Understanding
Singh, T., Pitts, A., Miles, C. H., & Ing, C. H. (2023) · Current anesthesiology reports · doi:10.1007/s40140-023-00592-y · Cited by 3
Neuroprotective effects of pterostilbene against isoflurane-induced apoptosis through regulating the JNK and PI3K/Akt pathway in neonatal rats
Liu, T.-D., Yang, K., & Li, F.-K. (2015) · Bangladesh Journal of Pharmacology · doi:10.3329/bjp.v10i1.21642 · Cited by 3
Propofol and Sevoflurane Anesthesia in Early Childhood Do Not Influence Seizure Threshold in Adult Rats
Piwowarczyk, P., Rypulak, E., Sysiak-Sławecka, J., Nieoczym, D., Socała, K., Właź, A., Właź, P., Turski, W. A., Czuczwar, M., & Borys, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182312367 · Cited by 3
Anesthesia in Pediatric Otolaryngology
Swanson, V. C., Taneja, P. A., Gries, H., & Koh, J. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-35671-8.00003-7 · Cited by 3
Repeated Sevoflurane Exposures in Neonatal Rats Increased the Brain Vulnerability to Future Stress Exposure and Resulted in Fear Extinction Deficit
Chen, B.-Z., Jiang, L., Ling, T., Zhou, W.-Q., Shang, Y.-C., Li, F., & Liu, B. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00529-z · Cited by 3
Transplantation of NEP1-40 and NT-3 Gene-Co-Transduced Neural Stem Cells Improves Function and Neurogenesis after Spinal Cord Injury in a Rat Model
Chen, F., Zhang, Z., Wang, L., Yang, X., Zhou, C., Zhu, C., Wang, L., Liu, L., & Song, Y. (2022) · Neurology India · doi:10.4103/0028-3886.360942 · Cited by 3
Post-Exposure Exercise Fails to Ameliorate Memory Impairment Induced by Propofol and Ketamine in Developing Rats
Jin, L., Song, Y., Shen, Y., Ji, W., & Zhang, M. (2016) · Medical Science Monitor · doi:10.12659/msm.895443 · Cited by 3
Chloride Homeodynamics Underlying Pathogenic Modal Shifts of GABA Actions
Fukuda, A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397266-8.00010-7 · Cited by 3
General anesthetics and neurotoxicity in the developing brain: A review of current literature
Szmuk, P., Olomuk, P., Pop, R. B., & Farrow-Gillespie, A. C. (2010) · Cited by 3
Molecular Imaging: A New Frontier in Neurotoxicology
Zhang, X., & Paule, M. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65837-3 · Cited by 3
Reaching Parents Through an Online Community
Boat, A. C., Monteleone, M., Lee, J., & Sun, L. S. (2018) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0000000000000539 · Cited by 3
Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient
Xu, J., Xu, M., Wang, Y., Mathena, R. P., Wen, J., Zhang, P., Furmanski, O., & Mintz, C. D. (2019) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2019.106812 · Cited by 3
Microglia-mediated Perineuronal nets loss contributes to social memory deficit in male mice after repeated neonatal sevoflurane exposure
Shi, Z., Qin, J., Gao, L., Fa, H., Wei, W., Zhao, T., Song, X., & Guo, X. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106148 · Cited by 2
Childhood anaesthesia and autism risk: population and murine study
Sun, M., Fu, N., Li, T., Miao, M., Chen, W., Wu, S., & Zhang, J. (2024) · Brain Communications · doi:10.1093/braincomms/fcae325 · Cited by 2
The Relationship between Early Exposure to General Anesthesia and Neurobehavioral Deficits
Xu, J., Wang, F., Gao, Y., Qi, C., Chen, T., & Yan, J. J. (2024) · Developmental Neuroscience · doi:10.1159/000542005 · Cited by 2
Pretreatment with tetramethylpyrazine alleviated the impairment of learning and memory induced by sevoflurane exposure in neonatal rats
Wang, K., Wei, H., Yang, L., Zhang, S., Cheng, Y., Chen, L., Jia, P., Zhang, Y., Zhang, Y., Fan, P., et al. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.013 · Cited by 2
Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models
Wang, C., Latham, L. E., Liu, S., Talpos, J. C., Patterson, T. A., Hanig, J. P., & Liu, F. (2025) · Experimental Biology and Medicine · doi:10.3389/ebm.2025.10606 · Cited by 2
Impact of sevoflurane anesthesia on S-adenosylmethionine in neonates under general anesthesia
Nagappa, S., Kalappa, S., Sridhara, R. B., Biligi, D. S., Annapoorneshwari, R., & Ramachandraiah (2024) · Journal of Anaesthesiology Clinical Pharmacology · doi:10.4103/joacp.joacp_26_24 · Cited by 2
GluN2B ‐Derived Small Interfering Peptide ( GluN2B ‐Sip) Protects Against Sevoflurane‐Induced Neurotoxicity in Developing Rats
Zhang, K., Liu, Y., Liao, Z., Zhang, M., Zhang, J., & Li, Y. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70118 · Cited by 2
Anesthetic drugs and the developing fetal brain
Gauthier, A., & Bradbury, C. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511734847.007 · Cited by 2
Neuronal vulnerability to anesthesia neurotoxicity depends on age of neurons
Xie, Z. (2013) · Annals of Neurology · doi:10.1002/ana.23914 · Cited by 2
Early anesthetic exposure and long-term cognitive impairment
Tao, F. (2011) · World Journal of Experimental Medicine · doi:10.5493/wjem.v1.i1.3 · Cited by 2
Dexmedetomidine: The Science and Clinical Aspects in Adults and Children
Mahmoud, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-47609-4_13 · Cited by 2
Developmental Neurotoxicity of General Anesthetics
Walters, J. L., & Paule, M. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00042-0 · Cited by 2
Sevoflurane induces apoptosis of isolated placental trophoblast cells and stimulates expressions of TNF-α and IL-6.
Hong, S., Li, Y., Su, D.-C., Mo, L., Han, B., Fang, Q., Hu, Z., Li, K., Chen, X., & Jia, J. (2019) · PubMed Central · Cited by 2
Effect of sugammadex, rocuronium and sevoflurane on oxidative stress and apoptosis in cerebral ischemia reperfusion model in rats
Çiftçi, H. (2023) · Northern Clinics of Istanbul · doi:10.14744/nci.2023.07888 · Cited by 2
IV. Increased kidney donation rates in the Scottish NHS: a historical problem being successfully addressed
Clancy, M. J., Miles, B. A., Logan, L., & Rooney, K. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu220 · Cited by 2
Neonatal sevoflurane exposure induces plasma biomarkers of inflammation in infant rhesus macaques
Kim, G., Love, K., Connor‐Stroud, F., Baxter, M. G., Alvarado, M. C., & Raper, J. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107535 · Cited by 1
Pain and anesthesia — on fetal nervous system and brain development
Gao, M. Q., Bao, G., & Bai, S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1710759 · Cited by 1
SHARPIN contributes to sevoflurane-induced neonatal neurotoxicity through up-regulating HMGB1 to repress M2 like-macrophage polarization
Cai, J., Lin, Y., Zhou, B., Xiao, F., Guohai, X., & Lu, J. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01355-2 · Cited by 2
miR-103-3p Delivered by Circulating Extracellular Vesicles Contributes to Anesthesia/Surgery-Induced Postoperative Delirium-Like Behaviors and Neuroinflammation in Aged Mice
Li, Y., Yan, X., Guo, Y., Ren, X., & Zhou, X. (2026) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.2025.j171 · Cited by 1
Sevoflurane, but not alphaxalone, causes lasting autism spectrum disorder-like pathology in male mice after exposure occurs during synaptogenesis
Volvovitz, B., Newson, A., Milosevic, A., Stamenić, T. T., Useinovic, N., Milosavljevic, N., Todorovic, S. M., & Jevtović‐Todorović, V. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110861 · Cited by 1
Neurodevelopmental Risks of Pediatric Anesthesia: What Do We Know, and What Should We Do?
Hays, S. R., & Deshpande, J. K. (2011) · Current Urology Reports · doi:10.1007/s11934-011-0172-6 · Cited by 1
The Role of Beta−Adrenergic Receptor Blockers in Autism
Lương, K. V. Q. (2013) · American Journal of Psychiatry and Neuroscience · doi:10.11648/j.ajpn.20130101.13 · Cited by 1
Neonatal Anesthesia Causes Long-term Disturbances of Hippocampal Synaptic Plasticity
Kato, R., Tachibana, K., Uchida, Y., Hashimoto, T., Takita, K., & Morimoto, Y. (2014) · THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA · doi:10.2199/jjsca.34.018 · Cited by 1
Evaluation of Dopamine Receptor Integrity after Sevo fl urane Exposure in Neonatal Rat Brain Using Positron Emission Tomography
Xuan, Z. (2018) · Global Journal of Anesthesiology · doi:10.17352/2455-3476.000040 · Cited by 1
In Vivo Systems: Animal Models of Neurodegeneration*
Zhang, X., & Paule, M. G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.01324-5 · Cited by 1
Surgery, Anesthesia, and the Immature Brain
Loepke, A. W., & Davidson, A. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-42974-0.00025-2 · Cited by 1
Postoperative Cognitive Function Following General Anesthesia in Children
Satomoto, M. (2019) · Neuromethods · doi:10.1007/978-1-4939-9891-3_10 · Cited by 1
Self-citation
Neonatal administration of a subanaesthetic dose of JM-1232(−) in mice results in no behavioural deficits in adulthood
Iwanaga, K., Satoh, Y., Akai, R., Ishizuka, T., Kazama, T., & Ikeda, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-92344-3 · Cited by 1
Self-citation
In Vivo Systems: Animal Models of Neurodegeneration
Zhang, X., & Paule, M. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.02208-x · Cited by 1
Brain Metabolism, the Pathophysiology of Brain Injury, and Potential Beneficial Agents and Techniques
Cottrell, J. E., Kass, I. S., Abramowicz, A. E., Hou, J. Y., & Lei, B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-93273-8.00001-8 · Cited by 1
Relevance to Clinical Anesthesia of Anesthetic‐Induced Neurotoxicity in Developing Animals
Creeley, C. E., Maze, M., & Olney, J. W. (2012) · Wiley eBooks · doi:10.1002/9781118477076.ch22 · Cited by 1
Anesthesia and Analgesia for Assisted Reproduction Techniques and other Procedures during the First Trimester
Palanisamy, A., & Tsen, L. C. (2012) · Wiley eBooks · doi:10.1002/9781118477076.ch16 · Cited by 1
Prenatal, Perinatal and Infancy History of Autism Spectrum Disorder
Nam, B. R., Yoo, H. J., Cho, I. H., Park, T. W., Son, J.-W., Chung, U., Shin, M., Kim, B.-N., Kim, J.-W., Yang, Y.-H., et al. (2010) · Journal of korean Academy of Child and Adolescent Psychiatry · doi:10.5765/jkacap.2010.21.3.153 · Cited by 1
Dexmedetomidine reduces isoflurane-induced neuroapoptosis through regulating BDNF and proBDNFPreprint
Ding, X., Zhang, H., Sun, S., Ma, C., Zheng, N., & Liu, H. (2021) · Research Square · doi:10.21203/rs.3.rs-596903/v1 · Cited by 1
Neurotoxicity of Anesthetic Agents for Developing and Adult Brain
Kato, R., Hashimoto, T., & Morimoto, Y. (2015) · Springer eBooks · doi:10.1007/978-4-431-54490-6_13
Effects of multiple exposures to sevoflurane at sub-MAC doses on neuroapoptosis and cognitive function during the neonatal period
Neira, A., Aguirre, L. F., Gómez, R. M., Barbosa, F. R., Pérez, J. A., & Muñoz, A. M. (2014) · Colombian Journal of Anesthesiology · doi:10.1016/j.rcae.2014.04.006
Molecules, magic and forgetful fruit flies: the supernatural science of medical gas research
Mychaskiw, G. (2011) · Medical Gas Research · doi:10.1186/2045-9912-1-23
Efectos de múltiples exposiciones a sevoflurano a dosis sub-CAM en la neuroapoptosis y la función cognitiva en el periodo neonatal
Neira, A., Aguirre, L. F., Gómez, R. M., Barbosa, F. R., Pérez, J. A., & Muñoz, A. M. (2014) · Colombian Journal of Anesthesiology · doi:10.1016/j.rca.2014.02.006
Anesthesia and White Matter Injury
Vlisides, P. E., & Xie, Z. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_24
Metabolomic analysis of the mechanism of isofluraneinduced apoptosis of PC12 cells
Ando, K., Urakami, K., Kusuhara, M., Tamai, S., & Morisaki, H. (2015) · Journal of Metabolomics · doi:10.7243/2059-0008-1-3
Efeitos da Anestesia geral no Neurodesenvolvimento Infantil
Mano, D. M. F. (2015) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/gm44-5571
Anaesthesia associated developmental neurotoxicity (AADN) 2015
Ramklass, R., Hauser, N. D., & Levin, A. I. (2016) · Southern African Journal of Anaesthesia and Analgesia · doi:10.1080/22201181.2015.1126980
Potential Risks of Early Exposure to Anesthesia in Childhood with Respect to Excitatory GABA Action during Development
Fukuda, A. (2011) · THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA · doi:10.2199/jjsca.31.001
To The Question of Safety of Neonatal Anesthesia
Martynyuk, A. E. (2012) · Journal of Pain & Relief · doi:10.4172/2167-0846.1000e104
Anesthesia-related Neurotoxicity in the Developing Brain : How It Can Be Reduced
Yufune, S. (2016) · THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA · doi:10.2199/jjsca.36.177
Postoperative Pain Management
Brookman, J. C., Benzon, H. T., Manohar, A., & Wu, C. L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-323-08340-9.00082-7
Studies on Developmental Exposures to Anesthetic Agents and Stem Cell Derived Models
Liu, F., Paule, M. G., Patterson, T. A., Wang, C., & Slikker, W. (2015) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814623186_0012
Neonatal Isoflurane Exposure on Apoptotic Neurodegeneration and Long-term Behavioral Functions
Maloney, S. E. (2012) · IRL - University of Missouri, St. Louis (University of Missouri–St. Louis)
Clinical Findings Including Prevention and Treatment
Satoh, Y. (2017) · Springer eBooks · doi:10.1007/978-4-431-55624-4_2
Self-citation
Propofol-induced changes in neurotrophic signaling in 14-day-old rat forebrain
Popić, J. (2012) · doi:10.2298/bg20120706popic
Affect of sevofluranein on the developmental hippocampal neurons of rats and its possible mechanism
Yu, P.-X., Bo, L., Zhang, F., & Dong, Z. (2018) · Biomedical Research - India · doi:10.4066/biomedicalresearch.29-17-2617
Anesthesia and Neurodegeneration
Vlisides, P. E., & Xie, Z. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316402504.008
Rhodioloside inhibits apoptosis of hippocampal neurons exposed to sevoflurane via cAMP/PKA signaling pathway
Su, Y., Bai, Y., Zheng, Z., & Fan, X. (2020) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v19i9.5
Sulfanilamide benzotriazole tetrazole inhibits neuronal apoptosis in neonatal rats by targeting JNK and p38 MAPK pathways
Hu, X., & Xiong, P. (2021) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v18i7.8
Developing Brain and Anesthetic Neurotoxicity
Bergese, S. D., & Sacchet-Cardozo, F. (2021) · Springer eBooks · doi:10.1007/978-981-16-3376-8_41
Current World Literature
(2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32833846de
Inhibition of miR-125b-5p Ameliorates Sevoflurane-Induced Neuroinflammation and Perioperative Neurocognitive Disorder by Suppressing Microglial M1 Polarization Via the A20/Nf-κB AxisPreprint
Li, N., Li, C., Sun, G., Sun, M., & Qi, F. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4047589
Introduction
Kapoor, I., Mahajan, C., & Prabhakar, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91003-3.00011-8
Chloride homeodynamics underlying pathogenic modal shifts of GABA actions
Fukuda, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00013-2
Do Anesthetic Drugs Harm Neonates? A Global Perspective
Hansen, T. G., Henneberg, S. W., & Engelhardt, T. (2023) · Springer eBooks · doi:10.1007/978-3-031-25358-4_18
Comparative Evaluation of the Effects of Sevoflurane and/or Dexmedetomidine on Behavior, Neuro-inflammation and Apoptosis in Pups Rat
Turhan, S., İnan, M. A., & Işık, B. (2023) · Journal of Contemporary Medicine · doi:10.16899/jcm.1297757
Pediatrik Kulak Burun Boğaz Hastalıkları
Gergin, Ö., Erkmen, B., Ünsal, M. P., Özkan, P. Y., Çitil, A. B., Çubuk, H., Fındık, M. O., AKUFUK, C., Gedik, M. S., Cırık, A. A., et al. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.2917
Gyosaponin ameliorates sevoflurane anesthesia-induced cognitive dysfunction and neuronal apoptosis in rats through modulation of the PI3K/AKT/mTOR pathway
Lin, L., Zhu, C., Yan, B., Yu, P., Yang, L., Huang, W., & Chen, J. (2024) · Clinics · doi:10.1016/j.clinsp.2024.100560
Association between anesthetics and autism spectrum disorder: from bench to bedside
Pan, R., Bi, Y., Zhou, S., Zhang, T., & Xu, A. (2025) · Journal of Anesthesia · doi:10.1007/s00540-025-03519-5
MiR-497/PLD regulation contributes to cognitive dysfunction in neonatal rats after repeated sevoflurane exposure
Que, Y., Chen, X., Liao, D., Zhang, D., & Zeng, D. (2025) · Brain and Development · doi:10.1016/j.braindev.2025.104409
Therapeutic Values of General Anesthetics: From Developmental Neurotoxicity to Neurotherapeutic Agents
Zhao, T., Guo, X., Shi, Z., Xu, H., Deng, S., Tang, H., Cai, H., & Song, X. (2025) · Current Neuropharmacology · doi:10.2174/011570159x388095251029043707
Single-cell transcriptomics reveals the mechanism of long-term neurodevelopmental toxicity following sevoflurane anesthesia
Xu, J., Wang, Z., Wang, H., Wen, H., Wen, Z., Chen, L., Cheng, Y., Yan, J., & Jiang, H. (2026) · NeuroToxicology · doi:10.1016/j.neuro.2026.103402
Etude des effets du sévoflurane sur le cerveau en développement
Brevaut‐Malaty, V. (2017) · doi:10.70675/9867256ez1f44z4ee2za5abzeb0f81216a21
Term or preterm cesarean section delivery does not lead to long-term detrimental consequences in mice
Chiesa, M. (2018) · theses.fr (ABES) · doi:10.70675/6ef32b4fzb74az4b06zb8edz92268c28d542
Long-term risk of depression after sevoflurane versus propofol anesthesia: a global propensity score–matched cohort study
Zhang, J., Miao, M., Wang, Y., Jiang, L., Zhu, R., Mao, T., Lu, Z., Wang, J., Zhao, L., Fu, S., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04075-6
Early childhood exposure to general anesthesia and subsequent risk of learning disabilities: a systematic review and meta-analysis of cohort studies
Zhou, H., Jin, Y., Zhou, H., Chen, X., Mak, H. Y., Hamdan, H., & Dong, C. (2026) · BMC Anesthesiology · doi:10.1186/s12871-026-04096-0
Neonatal sevoflurane exposure disrupts oligodendroglial development and TGF-β-associated signaling in the prefrontal cortex and hypothalamus, with persistent behavioral deficits
Yu, H., Dong, Y., Liu, G., Gu, Z., Qiu, J., Bi, J., Zhao, Q., Chen, Z., Liu, A., & Song, R. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106251
Neuroinflammation: an important mechanism of sevoflurane-induced developmental neurotoxicity
Liu, X., Zhou, Y., & Xiang, T. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1979399

Authors: Satomoto, M., Satoh, Y., Terui, K., Miyao, H., Takishima, K., Ito, M., & Imaki, J.
Affiliations: National Defense Medical College (JP)
Assistant Professor.
Associate Professor, Department of Obstetric Anesthesia.
Saitama Medical Center, Saitama Medical University (JP)
Associate Professor.
Professor, Department of Developmental Anatomy and Regenerative Biology.
ORCID: Satomoto, Maiko
Satoh, Yasushi
Miyao, Hideki
Ito, Masataka
Venue: Anesthesiology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-03-01
Volume: 110
Issue: 3
Pages: 628-637
ISSN: 0003-3022 (ISSN-L)
DOI: 10.1097/aln.0b013e3181974fa2
OpenAlex: W2036450246
Cited by: 496
References: 31
Citations by year: 2026: 5 · 2025: 12 · 2024: 18 · 2023: 15 · 2022: 30 · 2021: 34 · 2020: 31 · 2019: 26 · 2018: 30 · 2017: 37 · 2016: 62 · 2015: 37 · 2014: 47 · 2013: 36 · 2012: 32
FWCI: 7.83
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Anesthesiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Defense Medical College
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: sevoflurane, neonatal anesthesia, inhalational anesthetics, social behavior, social recognition memory, fear conditioning, learning deficits, apoptosis, caspase-3, autism spectrum disorder, NMDA receptor antagonism, developmental neurotoxicity
MeSH terms: Sevoflurane, Animals, Animals, Newborn, Conditioning, Psychological, Fear, Learning Disabilities, Male, Memory Disorders, Methyl Ethers, Mice, Inbred C57BL, Social Behavior, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neonatal Exposure to Sevoflurane Induces Abnormal Social Behaviors and Deficits in Fear Conditioning in Mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks