Cited by 2,194Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchFunctional Brain Connectivity Studies

Neural synchrony in brain disorders: Relevance for cognitive dysfunctions and pathophysiology

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Uhlhaas, Peter J., Singer, Wolf·2006·Neuron

Abstract

Following the discovery of context-dependent synchronization of oscillatory neuronal responses in the visual system, novel methods of time series analysis have been developed for the examination of task- and performance-related oscillatory activity and its synchronization. Studies employing these advanced techniques revealed that synchronization of oscillatory responses in the beta- and gamma-band is involved in a variety of cognitive functions, such as perceptual grouping, attention-dependent stimulus selection, routing of signals across distributed cortical networks, sensory-motor integration, working memory, and perceptual awareness. Here, we review evidence that certain brain disorders, such as schizophrenia, epilepsy, autism, Alzheimer's disease, and Parkinson's are associated with abnormal neural synchronization. The data suggest close correlations between abnormalities in neuronal synchronization and cognitive dysfunctions, emphasizing the importance of temporal coordination. Thus, focused search for abnormalities in temporal patterning may be of considerable clinical relevance.

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Crossref · 10.1016/j.neuron.2006.09.020

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  • Contour integration deficits in schizophrenia are thought to result from decreased NMDA-modulated lateral excitation among the spatial filters signaling the elements and the consequent reduction in synchronization of this neural activity.

    “This is thought to result from decreased NMDA-modulated lateral excitation among the spatial filters signaling these elements and the consequent reduction in synchronization of this neural activity ([68]; see also for reviews [69,70]).”

    From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [70]

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Authors
Uhlhaas, P. J., & Singer, W.
Affiliations
Goethe University Frankfurt (DE)
Corresponding author
Uhlhaas, Peter J.
Venue
Neuron
Publisher
Elsevier BV
Published
2006-10
Volume
52
Issue
1
Pages
155-168
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2157586156
Cited by
2,194
References
159
Citations by year
2026: 96 · 2025: 101 · 2024: 107 · 2023: 131 · 2022: 123 · 2021: 119 · 2020: 141 · 2019: 128 · 2018: 132 · 2017: 87 · 2016: 115 · 2015: 111 · 2014: 121 · 2013: 116 · 2012: 119
FWCI
6.00
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
Max-Planck-Gesellschaft
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
neuronal synchronization, neural oscillations, beta band, gamma band, cognitive impairment, schizophrenia, epilepsy, autism spectrum disorder, Alzheimer's disease, Parkinson's disease, perceptual grouping, attention, working memory, sensorimotor integration, perceptual awareness, cortical networks, temporal coordination
MeSH terms
Alzheimer Disease, Animals, Autistic Disorder, Brain Diseases, Brain Mapping, Cognition Disorders, Cortical Synchronization, Epilepsy, Humans, Parkinson Disease

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