Neural synchrony in brain disorders: Relevance for cognitive dysfunctions and pathophysiology
Open accessAbstract
Following the discovery of context-dependent synchronization of oscillatory neuronal responses in the visual system, novel methods of time series analysis have been developed for the examination of task- and performance-related oscillatory activity and its synchronization. Studies employing these advanced techniques revealed that synchronization of oscillatory responses in the beta- and gamma-band is involved in a variety of cognitive functions, such as perceptual grouping, attention-dependent stimulus selection, routing of signals across distributed cortical networks, sensory-motor integration, working memory, and perceptual awareness. Here, we review evidence that certain brain disorders, such as schizophrenia, epilepsy, autism, Alzheimer's disease, and Parkinson's are associated with abnormal neural synchronization. The data suggest close correlations between abnormalities in neuronal synchronization and cognitive dysfunctions, emphasizing the importance of temporal coordination. Thus, focused search for abnormalities in temporal patterning may be of considerable clinical relevance.
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Contour integration deficits in schizophrenia are thought to result from decreased NMDA-modulated lateral excitation among the spatial filters signaling the elements and the consequent reduction in synchronization of this neural activity.
“This is thought to result from decreased NMDA-modulated lateral excitation among the spatial filters signaling these elements and the consequent reduction in synchronization of this neural activity ([68]; see also for reviews [69,70]).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [70]
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- Authors
- Uhlhaas, P. J., & Singer, W.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Uhlhaas, Peter J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 52
- Issue
- 1
- Pages
- 155-168
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2157586156
- Semantic Scholar
- a6af2897d55300b538eb308b5d45c3478f819a46
- Cited by
- 2,194
- References
- 159
- Citations by year
- 2026: 96 · 2025: 101 · 2024: 107 · 2023: 131 · 2022: 123 · 2021: 119 · 2020: 141 · 2019: 128 · 2018: 132 · 2017: 87 · 2016: 115 · 2015: 111 · 2014: 121 · 2013: 116 · 2012: 119
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- neuronal synchronization, neural oscillations, beta band, gamma band, cognitive impairment, schizophrenia, epilepsy, autism spectrum disorder, Alzheimer's disease, Parkinson's disease, perceptual grouping, attention, working memory, sensorimotor integration, perceptual awareness, cortical networks, temporal coordination
- MeSH terms
- Alzheimer Disease, Animals, Autistic Disorder, Brain Diseases, Brain Mapping, Cognition Disorders, Cortical Synchronization, Epilepsy, Humans, Parkinson Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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