The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Hydroxyethyl Starches: Different Products – Different Effects
Abstract
With the development of a new generation of hydroxyethyl starches (HES), there has been renewed interest in their clinical potential. High doses of first- and second-generation HES were associated with adverse effects on renal function, coagulation, and tissue storage, thereby limiting their clinical applicability. Newer HES products have lower molar substitution and in vivo molecular weight, resulting in more rapid metabolism and clearance. In this review article, the differences between HES generations are highlighted, with particular emphasis on the improved safety profile of the third generation products. These improvements have been achieved with no loss of efficacy, and they contradict the assumption that efficacy of HES solutions is directly linked to plasma concentration. The impact of source material on structure and pharmacokinetics is highlighted, and the role of the carrier solution is critically assessed.
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Cites
9 retracted
Lang, K., Boldt, J., Suttner, S., & Haisch, G. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200108000-00034 · Cited by 250
RetractedBoldt, J., Brosch, C., Ducke, M., Papsdorf, M., & Lehmann, A. C. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000288101.02556.de · Cited by 103
RetractedBoldt, J., Ducke, M., Kumle, B., Papsdorf, M., & Zurmeyer, E.-L. (2004) · Intensive Care Medicine · doi:10.1007/s00134-003-2110-7 · Cited by 93
RetractedBoldt, J., Brosch, C., Röhm, K. D., Papsdorf, M., & Mengistu, A. M. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen016 · Cited by 86
RetractedKumle, B., Boldt, J., Piper, S., et al. (1999) · Anesthesia & Analgesia · doi:10.1213/00000539-199911000-00009 · Cited by 76
RetractedBoldt, J., Schölhorn, T., Mayer, J., Piper, S., & Suttner, S. W. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000221179.07006.06 · Cited by 55
RetractedBoldt, J., Brosch, C., Röhm, K. D., Lehmann, A. C., Mengistu, A. M., & Suttner, S. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31818370b2 · Cited by 40
RetractedBoldt, J., Suttner, S., Brosch, C., Lehmann, A. C., Röhm, K. D., & Mengistu, A. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1287-1 · Cited by 39
RetractedBoldt, J., Hüttner, I., Suttner, S., et al. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.3.435 · Cited by 35
RetractedEarly goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
Cited by
Guidet, B., Martinet, O., Boulain, T., Philippart, F., Poussel, J., Maizel, J., Forceville, X., Feissel, M., Hasselmann, M., Heininger, A., et al. (2012) · Critical Care · doi:10.1186/cc11358 · Cited by 344
Self-citation
Metadata
- Authors
- Westphal, M., James, M. F. M., Kozek-Langenecker, S., Stocker, R., Guidet, B., Van Aken, H., & Warner, M. A.
- Venue
- Anesthesiology
- Published
- 2009-07-01
- Volume
- 111
- Issue
- 1
- Pages
- 187-202
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2003269194
- Cited by
- 383
- References
- 52
- FWCI
- 20.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Westphal, M., James, M. F. M., Kozek-Langenecker, S., Stocker, R., Guidet, B., Van Aken, H., & Warner, M. A. (2009). Hydroxyethyl Starches: Different Products – Different Effects. Anesthesiology. https://doi.org/10.1097/aln.0b013e3181a7ec82
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
