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A Web-Based Lifestyle Intervention for Women With Recent Gestational Diabetes Mellitus: A Randomized Controlled Trial
Open accessAbstract
OBJECTIVE: To test the feasibility and effectiveness of a Web-based lifestyle intervention based on the Diabetes Prevention Program modified for women with recent gestational diabetes mellitus to reduce postpartum weight retention. METHODS: We randomly allocated 75 women with recent gestational diabetes mellitus to either a Web-based lifestyle program (Balance after Baby) delivered over the first postpartum year or to a control group. Primary outcomes were change in body weight at 12 months from 1) first postpartum measured weight; and 2) self-reported prepregnancy weight. RESULTS: There were no significant differences in baseline characteristics between groups including age, body mass index, race, and income status. Women assigned to the Balance after Baby program (n=36, three lost to follow-up) lost a mean of 2.8 kg (95% confidence interval -4.8 to -0.7) from 6 weeks to 12 months postpartum, whereas the control group (n=39, one lost to follow-up) gained a mean of 0.5 kg (-1.4 to +2.4) (P=.022). Women in the intervention were closer to prepregnancy weight at 12 months postpartum (mean change -0.7 kg; -3.5 to +2.2) compared with women in the control arm (+4.0 kg; +1.3 to +6.8) (P=.035). CONCLUSION: A Web-based lifestyle modification program for women with recent gestational diabetes mellitus decreased postpartum weight retention. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT01158131. LEVEL OF EVIDENCE: I.
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“In addition, 2 (15.4%) studies [40,44] reported prevention effectiveness of DCP, and both had a neutral effect.”
From Digital Health Interventions to Prevent Type 2 Diabetes Mellitus: Systematic Review (2025) · cites this paper as [40]
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“Of the 5 (13.5%) studies on PHT reporting its effects on preventing T2DM, 1 (20%) study [39] posted a positive effect, with 4 (80%) other studies [35,36,40,41] reporting a neutral effect on T2DM development.”
From Digital Health Interventions to Prevent Type 2 Diabetes Mellitus: Systematic Review (2025) · cites this paper as [40]
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“Of the 12 studies (92.3%) assessing the effects of dysglycemia, 9 (75%) reported positive population health outcomes, such as significant HbA1c reduction compared to the control group in Kim et al [45] using virtual reality (VR) technology and Everett et al [46] using AI interventions (P<.05). Furthermore, 3 (25%) studies [40,44,47] showed the effect was neutral.”
From Digital Health Interventions to Prevent Type 2 Diabetes Mellitus: Systematic Review (2025) · cites this paper as [40]
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“Of the 5 (20%) studies reporting the effects of TM on T2DM development, only 1 (20%) study by Sakane et al [39] indicated that TM is effective. The other 4 (80%) studies [35,40,44,50] did not show any significant differences compared to the control group.”
From Digital Health Interventions to Prevent Type 2 Diabetes Mellitus: Systematic Review (2025) · cites this paper as [40]
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Metadata
- Authors
- Nicklas, J. M., Zera, C. A., England, L. J., Rosner, B. A., Horton, E., Levkoff, S. E., & Seely, E. W.
- Affiliations
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- Obstetrics & Gynecology
- Published
- 2014-09
- Volume
- 124
- Issue
- 3
- Pages
- 563-570
- ISSN
- 0029-7844 (ISSN-L)
- PMC
- PMC4401073
- OpenAlex
- W1981309817
- Cited by
- 140
- References
- 30
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 17 · 2023: 14 · 2022: 12 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 17 · 2017: 9 · 2016: 7 · 2015: 12 · 2014: 1
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (CC999999)
- U.S. Public Health Service (MM-1094-09/09)
- National Heart, Lung, and Blood Institute (K24HL096141)
- National Center for Complementary and Integrative Health (T32AT000051)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD057022)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- gestational diabetes mellitus, postpartum weight retention, Diabetes Prevention Program, postpartum weight loss, pre-pregnancy weight, women
- MeSH terms
- Adult, Behavior Therapy, Female, Humans, Life Style, Obesity, Pregnancy, Preventive Health Services, Program Evaluation, Weight Gain, Body Mass Index, Diabetes, Gestational, Treatment Outcome, Risk Reduction Behavior, Postpartum Period
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