Effect of alcohol consumption on in vitro fertilization
Open accessAbstract
OBJECTIVE: To estimate whether alcohol use at the initiation of an in vitro fertilization (IVF) cycle is associated with IVF outcomes. METHODS: In this prospective cohort study, men and women completed a self-administered questionnaire before their first IVF cycle. Participants reported alcohol type, amount, and frequency consumed. Discrete survival analysis was applied to calculate the odds ratio (OR) and 95% confidence interval (CI) for live birth-the primary outcome. Secondary outcomes were cycle characteristics and points of failure in the IVF process (cycle cancellation, failed fertilization, implantation failure, and spontaneous abortion). We conducted multicycle analyses with final models adjusted for potential confounders that included cycle number, cigarette use, body mass index, and age. RESULTS: A total of 2,545 couples contributed 4,729 cycles. Forty-one percent of women and 58% of men drank one to six drinks per week. Women drinking at least four drinks per week had 16% less odds of a live birth rate compared with those who drank fewer than four drinks per week (OR 0.84, CI 0.71-0.99). For couples in which both partners drank at least four drinks per week, the odds of live birth were 21% lower compared with couples in which both drank fewer than four drinks per week (OR 0.79; CI 0.66-0.96). CONCLUSION: Consumption of as few as four alcoholic drinks per week is associated with a decrease in IVF live birth rate. LEVEL OF EVIDENCE: II.
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High alcohol consumption (more than two drinks per day, with one drink over 10 g ethanol) can impair female and male fertility and fertility treatment success.
“Consuming high levels of alcohol (> 2 drinks per day, with 1 drink > 10 g of ethanol) can affect both female and male fertility and the success of fertility treatment (Hakim 1998, Klonoff-Cohen 2003, Rossi 2011).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Rossi 2011
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Preconception lifestyle advice for people with infertility
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Self-citation
- Authors
- Rossi, B. V., Berry, K. F., Hornstein, M. D., Cramer, D. W., Ehrlich, S., & Missmer, S. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Obstetrics & Gynecology
- Published
- 2011-01
- Volume
- 117
- Issue
- 1
- Pages
- 136-142
- ISSN
- 0029-7844 (ISSN-L)
- PMC
- PMC4487775
- OpenAlex
- W2318053181
- Cited by
- 77
- References
- 18
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 9 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD032153)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- alcohol consumption, in vitro fertilization, live birth rate, IVF outcomes, implantation failure, cycle cancellation, fertilization failure, miscarriage, couples
- MeSH terms
- Adult, Alcohol Drinking, Birth Rate, Female, Fertilization in Vitro, Humans, Male, Prospective Studies
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