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Size Matters: Defining Critical in Bone Defect Size!
Abstract
Summary: Bone defects are common and are associated with a significant burden of disease. The treatment of these injuries remains controversial, particularly those defects which are critical sized. Despite the need for decision making to be evidence based, a lack of consensus around definitions of critical-sized defects still exists, particularly around those defects in the 1–3 cm range. There is a need to define “critical” in bone defect size because noncritical defects may heal without planned reconstruction and secondary surgery. This article reviews the current evidence around the definition of a critical-sized bone defect and concludes that defects in the order of 2.5 cm or greater seem to have a poor natural history.
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Cited by
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Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 892
Biodegradable materials for bone defect repair
Wei, S., Ma, J.-X., Xu, L., Gu, X.-S., & Ma, X.-L. (2020) · Military Medical Research · doi:10.1186/s40779-020-00280-6 · Cited by 406
Jin, S.-S., He, D.-Q., Luo, D., Wang, Y., Yu, M., Guan, B., Fu, Y., Li, Z.-X., Zhang, T., Zhou, Y.-H., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00489 · Cited by 357
Applications of decellularized extracellular matrix in bone and cartilage tissue engineering
Kim, Y. S., Majid, M., Melchiorri, A. J., & Mikos, A. G. (2019) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10110 · Cited by 322
Zha, Y., Li, Y., Lin, T., Chen, J., Zhang, S., & Wang, J. (2021) · Theranostics · doi:10.7150/thno.50741 · Cited by 232
Metadata
- Authors
- Schemitsch, E. H.
- Venue
- Journal of Orthopaedic Trauma
- Published
- 2017-10
- Volume
- 31
- Issue
- 5
- Pages
- S20-S22
- ISSN
- 0890-5339 (ISSN-L)
- OpenAlex
- W2759529239
- Cited by
- 501
- References
- 0
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schemitsch, E. H. (2017). Size Matters: Defining Critical in Bone Defect Size! Journal of Orthopaedic Trauma. https://doi.org/10.1097/bot.0000000000000978
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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