Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects
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In our current work, we designed specifically engineered exosomes based on the requirements of vascularized bone repair in segmental bone defects. This work simultaneously illuminates the potential of functional exosomes in acellular tissue engineering.
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ATDC5-derived exosomes loaded with VEGF gene can effectively restore segmental bone defects by increasing osteogenesis and angiogenesis.
“Zha et al. extracted ATDC5 (chondrogenic progenitor cell line)-derived exosomes to load the vascular endothelial growth factor (VEGF) gene, which can effectively restore segmental bone defects by increasing osteogenesis and angiogenesis [86].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [86]
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- Authors
- Zha, Y., Li, Y., Lin, T., Chen, J., Zhang, S., & Wang, J.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Corresponding author
- Zhang, Shengmin
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 11
- Issue
- 1
- Pages
- 397-409
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC7681080
- OpenAlex
- W3095185855
- Cited by
- 232
- References
- 47
- Citations by year
- 2026: 25 · 2025: 55 · 2024: 55 · 2023: 48 · 2022: 39 · 2021: 10
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (2017YFC1103900, 31670968, 91939111, SZSM201812055, 31800805, 81601610)
- Sanming Project of Medicine in Shenzhen (SZSM201812055)
- National Key Research and Development Program of China (2018YFC1105700, 2017YFC1103900)
- Fundamental Research Funds for the Central Universities (2019kfyRCPY103)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- exosomes, progenitor cells, vascular endothelial growth factor, osteogenic induction, vascular remodeling, segmental bone defect, gene delivery
- MeSH terms
- Animals, Bone and Bones, Bone Regeneration, Cell Adhesion, Cell Line, Male, Materials Testing, Osteogenesis, Plasmids, Polyesters, Radius, Stem Cells, Tissue Engineering, Vascular Endothelial Growth Factor A, Cell Proliferation, Mice, Rats, Tissue Scaffolds, X-Ray Microtomography, Exosomes, Vascular Remodeling, Printing, Three-Dimensional
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