The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Muscle Weakness and 5-Year Survival in Acute Respiratory Distress Syndrome Survivors*
Open accessAbstract
Objectives: To longitudinally evaluate the association of post-ICU muscle weakness and associated trajectories of weakness over time with 5-year survival. Design: Longitudinal prospective cohort study over 5 years of follow-up. Setting: Thirteen ICUs in four hospitals in Baltimore, MD. Patients: One hundred fifty-six acute respiratory distress syndrome survivors. Interventions: None. Measurements and Main Results: Strength was evaluated with standardized manual muscle testing using the Medical Research Council sum score (range, 0–60; higher is better), with post-ICU weakness defined as sum score less than 48. Muscle strength was assessed at hospital discharge and at 3, 6, 12, 24, 36, and 48 months after acute respiratory distress syndrome. At discharge, 38% of patients had muscle weakness. Every one point increase in sum score at discharge was associated with improved survival (hazard ratio [95% CI], 0.96 [0.94–0.98]), with similar findings longitudinally (0.95 [0.93–0.98]). Having weakness at discharge was associated with worse 5-year survival (1.75 [1.01–3.03]), but the association was attenuated (1.54 [0.82–2.89]) when evaluated longitudinally over follow-up. Persisting and resolving trajectories of muscle weakness, occurring in 50% of patients during follow-up, were associated with worse survival (3.01 [1.12-8.04]; and 3.14 [1.40-7.03], respectively) compared to a trajectory of maintaining no muscle weakness. Conclusions: At hospital discharge, greater than one third of acute respiratory distress syndrome survivors had muscle weakness. Greater strength at discharge and throughout follow-up was associated with improved 5-year survival. In patients with post-ICU weakness, both persisting and resolving trajectories were commonly experienced and associated with worse survival during follow-up.
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Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
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“In this cohort study, conducted in 13 medical, surgical, and trauma ICUs at four teaching hospitals in Baltimore, MD, we prospectively screened and enrolled consecutive mechanically ventilated patients meeting the American-European Consensus Conference criteria for acute lung injury (ALI) (16) that were in effect duri…”
InfluentialEly, E. W., Inouye, S. K., Bernard, G. R., Gordon, S., Francis, J., May, L., Truman, B., Speroff, T., Gautam, S., Margolin, R., et al. (2001) · JAMA · doi:10.1001/jama.286.21.2703 · Cited by 3,210
Physical Complications in Acute Lung Injury Survivors: A Two-Year Longitudinal Prospective Study
Fan, E., Dowdy, D. W., Colantuoni, E., Mendez-Tellez, P. A., Sevransky, J. E., Shanholtz, C., Dennison Himmelfarb, C. R., Desai, S. V., Ciesla, N., Herridge, M. S., et al. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000040 · Cited by 615
Self-citationChanges in hospital mortality for United States intensive care unit admissions from 1988 to 2012
Zimmerman, J. E., Kramer, A. A., & Knaus, W. A. (2013) · Critical Care · doi:10.1186/cc12695 · Cited by 533
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“org March 2017 • Volume 45 • Number 3 in ICU survivors, even in the recovery process, since they often experience profound and persistent muscle wasting and weakness in the ICU, along other complications of bed rest (10, 40, 41).”
Cited by
Vanhorebeek, I., Latronico, N., & Van den Berghe, G. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05944-4 · Cited by 717
Gorman, E. A., O’Kane, C. M., & McAuley, D. F. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01439-8 · Cited by 423
Devlin, J. W., Skrobik, Y., Gélinas, C., Needham, D. M., Slooter, A. J. C., Pandharipande, P. P., Watson, P. L., Weinhouse, G. L., Nunnally, M. E., Rochwerg, B., et al. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003259 · Cited by 372
Self-citationBruno, R. R., Wolff, G., Wernly, B., Masyuk, M., Piayda, K., Leaver, S., Erkens, R., Oehler, D., Afzal, S., Heidari, H., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04202-x · Cited by 242
Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections
Stubbs, B. J., Koutnik, A. P., Goldberg, E. L., Upadhyay, V., Turnbaugh, P. J., Verdin, E., & Newman, J. C. (2020) · Med · doi:10.1016/j.medj.2020.06.008 · Cited by 71
Metadata
- Authors
- Dinglas, V. D., Aronson Friedman, L., Colantuoni, E., Mendez-Tellez, P. A., Shanholtz, C. B., Ciesla, N. D., Pronovost, P. J., & Needham, D. M.
- Venue
- Critical Care Medicine
- Published
- 2017-03
- Volume
- 45
- Issue
- 3
- Pages
- 446-453
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2571548403
- Cited by
- 210
- References
- 7
- FWCI
- 15.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Dinglas, V. D., Aronson Friedman, L., Colantuoni, E., Mendez-Tellez, P. A., Shanholtz, C. B., Ciesla, N. D., Pronovost, P. J., & Needham, D. M. (2017). Muscle Weakness and 5-Year Survival in Acute Respiratory Distress Syndrome Survivors*. Critical Care Medicine. https://doi.org/10.1097/ccm.0000000000002208
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