The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Delirium and Mortality in Critically Ill Children: Epidemiology and Outcomes of Pediatric Delirium
Open accessAbstract
OBJECTIVES: Delirium occurs frequently in adults and is an independent predictor of mortality. However, the epidemiology and outcomes of pediatric delirium are not well-characterized. The primary objectives of this study were to describe the frequency of delirium in critically ill children, its duration, associated risk factors, and effect on in-hospital outcomes, including mortality. Secondary objectives included determination of delirium subtype, and effect of delirium on duration of mechanical ventilation, and length of hospital stay. DESIGN: Prospective, longitudinal cohort study. SETTING: Urban academic tertiary care PICU. PATIENTS: All consecutive admissions from September 2014 through August 2015. INTERVENTIONS: Children were screened for delirium twice daily throughout their ICU stay. MEASUREMENTS AND MAIN RESULTS: Of 1,547 consecutive patients, delirium was diagnosed in 267 (17%) and lasted a median of 2 days (interquartile range, 1-5). Seventy-eight percent of children with delirium developed it within the first 3 PICU days. Most cases of delirium were of the hypoactive (46%) and mixed (45%) subtypes; only 8% of delirium episodes were characterized as hyperactive delirium. In multivariable analysis, independent predictors of delirium included age less than or equal to 2 years old, developmental delay, severity of illness, prior coma, mechanical ventilation, and receipt of benzodiazepines and anticholinergics. PICU length of stay was increased in children with delirium (adjusted relative length of stay, 2.3; CI = 2.1-2.5; p < 0.001), as was duration of mechanical ventilation (median, 4 vs 1 d; p < 0.001). Delirium was a strong and independent predictor of mortality (adjusted odds ratio, 4.39; CI = 1.96-9.99; p < 0.001). CONCLUSIONS: Delirium occurs frequently in critically ill children and is independently associated with mortality. Some in-hospital risk factors for delirium development are modifiable. Interventional studies are needed to determine best practices to limit delirium exposure in at-risk children.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Even after accounting for illness severity, delirium is associated with increased short- and long-term morbidity, leading to higher healthcare resource utilization and expenditure, and mortality [7,61,64,65,66].”
From Psychological and Psychiatric Comorbidities in Youth with Serious Physical Illness (2022) · cites this paper as [66]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Barr, J., Fraser, G. L., Puntillo, K., Ely, E. W., Gélinas, C., Dasta, J. F., Davidson, J. E., Devlin, J. W., Kress, J. P., Joffe, A. M., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182783b72 · Cited by 3,896
Sessler, C. N., Gosnell, M. S., Grap, M. J., Brophy, G. M., O'Neal, P. V., Keane, K. A., Tesoro, E. P., & Elswick, R. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2107138 · Cited by 3,695
Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
Ely, E. W. (2004) · JAMA · doi:10.1001/jama.291.14.1753 · Cited by 3,073
A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye, S. K., Bogardus, S. T., Charpentier, P. A., Leo-Summers, L. S., Acampora, D., Holford, T. R., & Cooney, L. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400901 · Cited by 2,904
Monitoring Sedation Status Over Time in ICU Patients
Ely, E. W., Truman, B., Shintani, A., Thomason, J. W. W., Wheeler, A. P., Gordon, S., Francis, J., Speroff, T., Gautam, S., Margolin, R. A., et al. (2003) · JAMA · doi:10.1001/jama.289.22.2983 · Cited by 1,704
Pandharipande, P. P., Pun, B. T., Herr, D., Maze, M., Girard, T. D., Miller, R. R., Shintani, A., Thompson, J. L., Jackson, J. C., Deppen, S. A., et al. (2007) · JAMA · doi:10.1001/jama.298.22.2644 · Cited by 1,456
Pandharipande, P. P., Shintani, A., Peterson, J. F., Pun, B. T., Wilkinson, G. R., Dittus, R. S., Bernard, G. R., & Ely, E. W. (2005) · Anesthesiology · doi:10.1097/00000542-200601000-00005 · Cited by 1,231
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
Girard, T. D., Jackson, J. C., Pandharipande, P. P., Pun, B. T., Thompson, J. L., Shintani, A., Gordon, S. M., Canonico, A. E., Dittus, R. S., Bernard, G. R., et al. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181e47be1 · Cited by 1,217
The impact of delirium in the intensive care unit on hospital length of stay
Ely, E. W., Gautam, S., Margolin, R. A., Francis, J., May, L., Speroff, T., Truman, B., Dittus, R. S., Bernard, G. R., & Inouye, S. K. (2001) · Intensive Care Medicine · doi:10.1007/s00134-001-1132-2 · Cited by 1,032
Neuropathogenesis of Delirium: Review of Current Etiologic Theories and Common Pathways
Maldonado, J. R. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.09.005 · Cited by 745
Cited by
Sorted by citations
Smith, H. A. B., Besunder, J. B., Betters, K. A., Johnson, P. N., Srinivasan, V., Stormorken, A., Farrington, E., Golianu, B. J., Godshall, A. J., Acinelli, L., et al. (2022) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000002873 · Cited by 537
Benzodiazepines and Development of Delirium in Critically Ill Children: Estimating the Causal Effect
Mody, K., Kaur, S., Mauer, E. A., Gerber, L. M., Greenwald, B. M., Silver, G., & Traube, C. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003194 · Cited by 161
Delirium is a Common and Early Finding in Patients in the Pediatric Cardiac Intensive Care Unit
Alvarez, R. V., Palmer, C., Czaja, A. S., Peyton, C., Silver, G., Traube, C., Mourani, P. M., & Kaufman, J. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.11.064 · Cited by 147
Delirium in Pediatric Critical Care
Patel, A. K., Bell, M. J., & Traube, C. (2017) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2017.06.009 · Cited by 122
Delirium in a Tertiary PICU: Risk Factors and Outcomes*
Dervan, L. A., Gennaro, J. L. D., Farris, R. W. D., & Watson, R. S. (2019) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000002126 · Cited by 124
Metadata
- Authors
- Traube, C., Silver, G., Gerber, L. M., Kaur, S., Mauer, E. A., Kerson, A., Joyce, C., & Greenwald, B. M.
- Affiliations
- Weill Cornell Medicine (US)
- NewYork–Presbyterian Hospital (US)
- Venue
- Critical Care Medicine
- Published
- 2017-05
- Volume
- 45
- Issue
- 5
- Pages
- 891-898
- ISSN
- 0090-3493 (ISSN-L)
- PMC
- PMC5392157
- OpenAlex
- W2593019651
- Cited by
- 379
- References
- 53
- Citations by year
- 2026: 36 · 2025: 41 · 2024: 37 · 2023: 48 · 2022: 45 · 2021: 54 · 2020: 42 · 2019: 31 · 2018: 28 · 2017: 15
- FWCI
- 29.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000457)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Keywords
- pediatric delirium, critically ill children, mortality, hypoactive delirium, hyperactive delirium, risk factors, mechanical ventilation duration, length of hospital stay, benzodiazepines, anticholinergic agents, developmental delay, intensive care unit
- MeSH terms
- Academic Medical Centers, Adolescent, Age Factors, Child, Developmental Disabilities, Child, Preschool, Delirium, Female, Humans, Infant, Infant, Newborn, Length of Stay, Longitudinal Studies, Male, Prospective Studies, Respiration, Artificial, Risk Factors, Severity of Illness Index, Time Factors, Intensive Care Units, Pediatric, Critical Illness, Hospital Mortality
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
