The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Usefulness of the “Candida score” for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: A prospective multicenter study
Abstract
OBJECTIVE: To assess the usefulness of the "Candida score" (CS) for discriminating between Candida species colonization and invasive candidiasis (IC) in non-neutropenic critically ill patients. A rate of IC <5% in patients with CS <3 was the primary end point. DESIGN: Prospective, cohort, observational study. SETTING: Thirty-six medical-surgical intensive care units of Spain, Argentina, and France. PATIENTS: A total of 1,107 non-neutropenic adult intensive care unit patients admitted for at least 7 days between April 2006 and June 2007. MEASUREMENTS AND MAIN RESULTS: Clinical data, surveillance cultures for fungal growth, and serum levels of (1-3)-beta-d-glucan and anti-Candida antibodies (in a subset of patients) were recorded. The CS was calculated as follows (variables coded as absent = 0, present = 1): total parenteral nutrition x1, plus surgery x1, plus multifocal Candida colonization x1, plus severe sepsis x2. A CS >or=3 accurately selected patients at high risk for IC. The colonization index was registered if >or=0.5. The rate of IC was 2.3% (95% confidence interval [CI] 1.06-3.54) among patients with CS <3, with a linear association between increasing values of CS and IC rate (p 7 days, with a CS <3 and not receiving antifungal treatment, the rate of IC was <5%. Therefore, IC is highly improbable if a Candida-colonized non-neutropenic critically ill patient has a CS <3.
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Cited by
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Metadata
- Authors
- León, C., Ruiz-Santana, S., Saavedra, P., Galván, B., Blanco, A., Castro, C., Balasini, C., Utande-Vázquez, A., González de Molina, F. J., Blasco-Navalproto, M. A., López, M. J., Charles, P. E., Martín, E., & Hernández-Viera, M. A.
- Venue
- Critical Care Medicine
- Published
- 2009-05
- Volume
- 37
- Issue
- 5
- Pages
- 1624-1633
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2112046323
- Cited by
- 375
- References
- 33
- FWCI
- 20.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- León, C., Ruiz-Santana, S., Saavedra, P., Galván, B., Blanco, A., Castro, C., Balasini, C., Utande-Vázquez, A., González de Molina, F. J., Blasco-Navalproto, M. A., López, M. J., Charles, P. E., Martín, E., & Hernández-Viera, M. A. (2009). Usefulness of the “Candida score” for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: A prospective multicenter study. Critical Care Medicine. https://doi.org/10.1097/ccm.0b013e31819daa14
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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