The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: Results of a three-year follow-up quasi-experimental study*
Abstract
OBJECTIVES: To describe the effectiveness of the Surviving Sepsis Campaign bundles with regard to both implementation and outcome in patients with septic shock and to determine the contribution of the various elements of the bundles to the outcome. DESIGN: Quasi-experimental study with a historical comparison group. SETTING: The three medical-surgical intensive care units of an academic tertiary care center. PATIENTS: A total of 384 adult patients in septic shock were enrolled after the educational intervention (September 2005-August 2008) and 96 patients in the historical group (June 2004-May 2005). INTERVENTION: A hospital-wide quality improvement program based on the implementation of the Surviving Sepsis Campaign guidelines performed between June 2005 and August 2005. MEASUREMENTS AND RESULTS: In-hospital mortality was reduced from 57.3% in the historical group to 37.5% in the intervention group (p = .001). This difference remained significant after controlling for confounding factors (odds ratio, 0.50; 95% confidence interval, 0.28-0.89). The intervention group had also lower length of stay for survivors in the hospital (36.2 +/- 34.8 days vs. 41.0 +/- 26.3 days; p = .043) and in the intensive care units (8.4 +/- 9.8 days vs. 11.0 +/- 9.5 days; p = .004). Improvements in survival were related to the number of bundle interventions completed (p for trend <.001). Compliance with six or more interventions of the 6-hr resuscitation bundle was an independent predictor of survival (adjusted odds ratio, 0.30; 95% confidence interval, 0.17-0.53; p <.001). The only single intervention with impact on mortality was the achievement of ScvO2 > or =70% (adjusted odds ratio, 0.62; 95% confidence interval, 0.38-0.99; p = .048). CONCLUSIONS: The implementation of the Surviving Sepsis Campaign guidelines was associated with a significant decrease in mortality. The benefits depend on the number of interventions accomplished within the time limits. The 6-hr resuscitation bundle showed greater compliance and effectiveness than the 24-hr management bundle.
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Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
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Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
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2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
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Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Dellinger, R. P., Carlet, J. M., Masur, H., Gerlach, H., Calandra, T., Cohen, J., Gea-Banacloche, J., Keh, D., Marshall, J. C., Parker, M. M., et al. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2210-z · Cited by 3,321
Annane, D. (2002) · JAMA · doi:10.1001/jama.288.7.862 · Cited by 3,087
Sepsis in European intensive care units: Results of the SOAP study*
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Simulation Study of Confounder-Selection Strategies
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Cited by
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694
Nationwide Trends of Severe Sepsis in the 21st Century (2000–2007)
Kumar, G., Kumar, N., Taneja, A., Kaleekal, T., Tarima, S., McGinley, E., Jimenez, E., Mohan, A., Khan, R. A., Whittle, J., et al. (2011) · Chest · doi:10.1378/chest.11-0352 · Cited by 615
A targeted real-time early warning score (TREWScore) for septic shock.
Henry, K. E., Hager, D. N., Pronovost, P. J., & Saria, S. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab3719 · Cited by 598
Mira, J. C., Gentile, L. F., Mathias, B. J., Efron, P. A., Brakenridge, S. C., Mohr, A. M., Moore, F. A., & Moldawer, L. L. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002074 · Cited by 526
Damiani, E., Donati, A., Serafini, G., Rinaldi, L., Adrario, E., Pelaia, P., Busani, S., & Girardis, M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0125827 · Cited by 275
Metadata
- Authors
- Castellanos-Ortega, Á., Suberviola, B., García-Astudillo, L. A., Holanda, M. S., Ortiz, F., Llorca, J., & Delgado-Rodríguez, M.
- Venue
- Critical Care Medicine
- Published
- 2010-04
- Volume
- 38
- Issue
- 4
- Pages
- 1036-1043
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2167642125
- Cited by
- 363
- References
- 32
- FWCI
- 23.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Castellanos-Ortega, Á., Suberviola, B., García-Astudillo, L. A., Holanda, M. S., Ortiz, F., Llorca, J., & Delgado-Rodríguez, M. (2010). Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: Results of a three-year follow-up quasi-experimental study*. Critical Care Medicine. https://doi.org/10.1097/ccm.0b013e3181d455b6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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