Cited by 300Posttraumatic Stress Disorder ResearchChild Abuse and TraumaChild Therapy and Development

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A Pilot Randomized Controlled Trial of Combined Trauma-Focused CBT and Sertraline for Childhood PTSD Symptoms

COHEN, JUDITH A., MANNARINO, ANTHONY P., PEREL, JAMES M., STARON, VIRGINIA·2007·Journal of the American Academy of Child & Adolescent Psychiatry

DOI 10.1097/chi.0b013e3180547105

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Abstract

Objective To examine the potential benefits of adding a selective serotonin reuptake inhibitor, sertraline, versus placebo, to trauma-focused cognitive-behavioral therapy (TF-CBT) for improving posttraumatic stress disorder and related psychological symptoms in children who have experienced sexual abuse.Method Twenty-four 10- to 17-year-old female children and adolescents and their primary caretakers were randomly assigned to receive TF-CBT + sertraline or TF-CBT + placebo for 12 weeks.Results Both groups experienced significant improvement in posttraumatic stress disorder and other clinical outcomes from pre- to posttreatment with no significant group x time differences between groups except in Child Global Assessment Scale ratings, which favored the TF-CBT + sertraline group.Conclusions Only minimal evidence suggests a benefit to adding sertraline to TF-CBT. A drawback of adding sertraline was determining whether TF-CBT or sertraline caused clinical improvement for children with comorbid depression. Current evidence therefore supports an initial trial of TF-CBT or other evidence-supported psychotherapy for most children with PTSD symptoms before adding medication.

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Authors: COHEN, J. A., MANNARINO, A. P., PEREL, J. M., & STARON, V.
Affiliations: University of Pittsburgh (US)
Corresponding author: COHEN, JUDITH A.
ORCID: COHEN, JUDITH A.
Venue: Journal of the American Academy of Child & Adolescent Psychiatry
Publisher: Elsevier BV
Published: 2007-07
Volume: 46
Issue: 7
Pages: 811-819
ISSN: 0890-8567 (ISSN-L)
DOI: 10.1097/chi.0b013e3180547105
OpenAlex: W2061598652
Cited by: 300
References: 27
Citations by year: 2026: 11 · 2025: 6 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 11 · 2020: 17 · 2019: 18 · 2018: 7 · 2017: 13 · 2016: 22 · 2015: 40 · 2014: 15 · 2013: 24 · 2012: 22
FWCI: 15.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (K02MH001938)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Child Therapy and Development
Keywords: trauma-focused cognitive behavioral therapy, sertraline, selective serotonin reuptake inhibitors, sexual abuse, comorbid depression, psychotherapy, adolescents, girls
MeSH terms: Adolescent, Child, Combined Modality Therapy, Female, Humans, Male, Pilot Projects, Stress Disorders, Post-Traumatic, Cognitive Behavioral Therapy, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Sertraline

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A Pilot Randomized Controlled Trial of Combined Trauma-Focused CBT and Sertraline for Childhood PTSD Symptoms

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