The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
A Pilot Randomized Controlled Trial of Combined Trauma-Focused CBT and Sertraline for Childhood PTSD Symptoms
Abstract
Objective To examine the potential benefits of adding a selective serotonin reuptake inhibitor, sertraline, versus placebo, to trauma-focused cognitive-behavioral therapy (TF-CBT) for improving posttraumatic stress disorder and related psychological symptoms in children who have experienced sexual abuse.Method Twenty-four 10- to 17-year-old female children and adolescents and their primary caretakers were randomly assigned to receive TF-CBT + sertraline or TF-CBT + placebo for 12 weeks.Results Both groups experienced significant improvement in posttraumatic stress disorder and other clinical outcomes from pre- to posttreatment with no significant group x time differences between groups except in Child Global Assessment Scale ratings, which favored the TF-CBT + sertraline group.Conclusions Only minimal evidence suggests a benefit to adding sertraline to TF-CBT. A drawback of adding sertraline was determining whether TF-CBT or sertraline caused clinical improvement for children with comorbid depression. Current evidence therefore supports an initial trial of TF-CBT or other evidence-supported psychotherapy for most children with PTSD symptoms before adding medication.
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“In particular, cognitive behavioral therapy (CBT) including trauma exposure techniques has proven to be effective for child victims of sexual abuse [8-10] and other forms of violence [11,12].”
From Treating children traumatized by war and tsunami: a comparison between exposure therapy and meditation-relaxation in north-east Sri Lanka (2009) · cites this paper as [9]
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“to psychotherapy alone in two RCTs [946,947], but was superior to pharmacotherapy alone in the other two trials”
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Metadata
- Authors
- COHEN, J. A., MANNARINO, A. P., PEREL, J. M., & STARON, V.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- COHEN, JUDITH A.
- ORCID
- COHEN, JUDITH A.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 46
- Issue
- 7
- Pages
- 811-819
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2061598652
- Cited by
- 300
- References
- 27
- Citations by year
- 2026: 11 · 2025: 6 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 11 · 2020: 17 · 2019: 18 · 2018: 7 · 2017: 13 · 2016: 22 · 2015: 40 · 2014: 15 · 2013: 24 · 2012: 22
- FWCI
- 15.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K02MH001938)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child Therapy and Development
- Keywords
- trauma-focused cognitive behavioral therapy, sertraline, selective serotonin reuptake inhibitors, sexual abuse, comorbid depression, psychotherapy, adolescents, girls
- MeSH terms
- Adolescent, Child, Combined Modality Therapy, Female, Humans, Male, Pilot Projects, Stress Disorders, Post-Traumatic, Cognitive Behavioral Therapy, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Sertraline
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