The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Autism Spectrum Disorders and Childhood-Onset Schizophrenia: Clinical and Biological Contributions to a Relation Revisited
Open accessAbstract
Objective To highlight emerging evidence for clinical and biological links between autism/Pervasive Developmental Disorder (PDD) and schizophrenia, with particular attention to childhood onset schizophrenia (COS). Method Clinical, demographic and brain developmental data from the NIMH (and other) COS studies, and selected family, imaging and genetic data from studies of autism, PDD and schizophrenia were reviewed. Results In the two large studies that have examined this systematically, COS is preceded by and comorbid with Pervasive Developmental Disorder in 30%-50% of cases. Epidemiologic and family studies find association between the disorders. Both disorders have evidence of accelerated trajectories of anatomic brain development at ages near disorder onset. A growing number of risk genes and/or rare small chromosomal variants (micro-deletions or duplications) are shared by schizophrenia and autism. Conclusion Biological risk does not closely follow DSM phenotypes and core neurobiological processes are likely common for subsets of these two heterogeneous clinical groups. Long-term prospective follow up of autistic populations, and greater diagnostic distinction between schizophrenia spectrum and autism spectrum disorders in adult relatives are needed.
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Cites
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Metadata
- Authors
- Rapoport, J., Chavez, A., Greenstein, D., Addington, A., & Gogtay, N.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 48
- Issue
- 1
- Pages
- 10-18
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2000010950
- Cited by
- 400
- References
- 82
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- Rapoport, J., Chavez, A., Greenstein, D., Addington, A., & Gogtay, N. (2009). Autism Spectrum Disorders and Childhood-Onset Schizophrenia: Clinical and Biological Contributions to a Relation Revisited. Journal of the American Academy of Child & Adolescent Psychiatry. https://doi.org/10.1097/chi.0b013e31818b1c63
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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