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Cited by 8Dermatologic Treatments and ResearchAdvancements in Transdermal Drug DeliveryTattoo and Body Piercing Complications

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Granulomatous Reactions From Microneedling: A Systematic Review of the Literature

Friedmann, Daniel P., Mehta, Eshani, Verma, Kritin K., Harris, Ryan·2025·Dermatologic Surgery
DOI 10.1097/dss.0000000000004450
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Abstract

BACKGROUND: Microneedling is a common minimally invasive procedure for skin rejuvenation. Granulomatous reactions after microneedling have been rarely reported. OBJECTIVE: To systematically review the literature for granulomatous reactions from microneedling. MATERIALS AND METHODS: A systematic review of the Medline, Scopus, Google Scholar, and Cochrane databases was performed for articles describing granulomatous reactions to microneedling. RESULTS: Thirteen studies were selected for inclusion after full-text review, which described 15 patients (26–74 years old) with non-necrotizing granulomatous inflammation postmicroneedling. Motorized microneedling pen use and topical Vitamin C application were implicated in a majority of cases. Although delayed-type hypersensitivity was commonly proposed as the underlying etiology, patch testing or further workup was rarely performed. Improvement or clearance occurred inconsistently with myriad treatment options, including topical steroids, oral antibiotics, and systemic anti-inflammatory medications. CONCLUSION: Granulomatous reactions to microneedling and microneedling-mediated transepidermal drug delivery can rarely occur and may be treatment-resistant.

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Research works printed but not linked: 33

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Metadata

Authors
Friedmann, D. P., Mehta, E., Verma, K. K., & Harris, R.
Affiliations
  • Westlake Dermatology Clinical Research Center, Westlake Dermatology & Cosmetic Surgery, Austin, Texas;
  • Vanderbilt University (US)
  • Texas Tech University (US)
  • Meridian Dermatology, Meridian, Idaho
Corresponding author
Friedmann, Daniel P.
ORCID
Venue
Dermatologic Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2024-11-25
Volume
51
Issue
3
Pages
263-266
ISSN
  • 1076-0512 (ISSN-L)
  • 1524-4725
DOI
10.1097/dss.0000000000004450
OpenAlex
W4404670188
Cited by
8
References
1
Citations by year
2026: 6 · 2025: 1 · 2024: 1
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Locations
  • Dermatologic Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Social Sciences › Cultural Studies › Tattoo and Body Piercing Complications
Keywords
microneedling, granulomatous inflammation, topical vitamin C, delayed-type hypersensitivity, topical corticosteroids, oral antibiotics, anti-inflammatory therapy
MeSH terms
Dry Needling, Percutaneous Collagen Induction, Adult, Aged, Cosmetic Techniques, Granuloma, Humans, Needles, Rejuvenation, Granuloma, Foreign-Body

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CoChat. (2026). Citation check: Granulomatous Reactions From Microneedling: A Systematic Review of the Literature. https://app.cochat.ai/papers/10.1097/dss.0000000000004450
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Friedmann, D. P., Mehta, E., Verma, K. K., & Harris, R. (2025). Granulomatous Reactions From Microneedling: A Systematic Review of the Literature. Dermatologic Surgery. https://doi.org/10.1097/dss.0000000000004450