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Cited by 29Folate and B Vitamins ResearchNutritional Studies and DietEpigenetics and DNA Methylation

Components of one-carbon metabolism other than folate and colorectal cancer risk

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Myte, Robin, Gylling, Björn, Schneede, Jörn, Ueland, Per Magne, Häggström, Jenny, Hultdin, Johan, Hallmans, Göran, Johansson, Ingegerd +2 more·2016·Epidemiology
DOI 10.1097/ede.0000000000000529
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Abstract

BACKGROUND: Despite extensive study, the role of folate in colorectal cancer remains unclear. Research has therefore begun to address the role of other elements of the folate-methionine metabolic cycles. This study investigated factors other than folate involved in one-carbon metabolism, i.e., choline, betaine, dimethylglycine, sarcosine, and methionine and relevant polymorphisms, in relation to the risk of colorectal cancer in a population with low intakes and circulating levels of folate. METHODS: This was a prospective case-control study of 613 case subjects and 1,190 matched control subjects nested within the population-based Northern Sweden Health and Disease Study. We estimated odds ratios (OR) by conditional logistic regression, and marginal risk differences with weighted maximum likelihood estimation using incidence data from the study cohort. RESULTS: Higher plasma concentrations of methionine and betaine were associated with modest colorectal cancer risk reductions (OR [95% confidence interval {CI}] for highest versus lowest tertile: 0.76 [0.57, 0.99] and 0.72 [0.55, 0.94], respectively). Estimated marginal risk differences corresponded to approximately 200 fewer colorectal cancer cases per 100,000 individuals on average. We observed no clear associations between choline, dimethylglycine, or sarcosine and colorectal cancer risk. The inverse association of methionine was modified by plasma folate concentrations (OR [95% CI] for highest/lowest versus lowest/lowest tertile of plasma methionine/folate concentrations 0.39 [0.24, 0.64], Pinteraction = 0.06). CONCLUSIONS: In this population-based, nested case-control study with a long follow-up time from baseline to diagnosis (median: 8.2 years), higher plasma concentrations of methionine and betaine were associated with lower colorectal cancer risk.See Video Abstract at http://links.lww.com/EDE/B83.

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  • Some but not all prospective studies associated higher dietary and plasma levels of choline with increased risk of colorectal neoplasia.

    “Some,147, 148 but not all,149–151 prospective studies have associated higher dietary and plasma levels of choline with increased risk of colorectal neoplasia.”

    From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [149]

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Authors
Myte, R., Gylling, B., Schneede, J., Ueland, P. M., Häggström, J., Hultdin, J., Hallmans, G., Johansson, I., Palmqvist, R., & Van Guelpen, B.
Affiliations
Haukeland University Hospital (NO)
ORCID
Venue
Epidemiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-11
Volume
27
Issue
6
Pages
787-796
ISSN
1044-3983 (ISSN-L)
DOI
10.1097/ede.0000000000000529
OpenAlex
W2461767167
Cited by
29
References
41
Citations by year
2024: 5 · 2023: 12 · 2022: 2 · 2021: 3 · 2019: 2 · 2018: 3 · 2017: 2
FWCI
2.48
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Epidemiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DiVA at Umeå University (Umeå University) (submittedVersion, other-oa)
Funders
  • Forskningsrådet för Arbetsliv och Socialvetenskap (2007-0925)
  • Cancerfonden (12/501, 14/780)
  • Västerbotten Läns Landsting
  • Vetenskapsrådet (K2012-55X-21100-04-3)
  • Umeå Universitet
  • Cancer Research Foundation in Northern Sweden
  • Medicinska fakulteten, Umeå Universitet
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
one-carbon metabolism, colorectal cancer risk, methionine, betaine, choline, dimethylglycine, sarcosine, folic acid, plasma biomarkers, genetic polymorphism
MeSH terms
Aged, Amino Acids, Betaine, Choline, Female, Folic Acid, Follow-Up Studies, Humans, Male, Methionine, Middle Aged, Prospective Studies, Sarcosine, Sweden, Biomarkers, Tumor, Colorectal Neoplasms, Biomarkers, Logistic Models, Odds Ratio, Case-Control Studies, Polymorphism, Single Nucleotide, Protective Factors

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