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Cited by 68Menopause: Health Impacts and TreatmentsHypothalamic control of reproductive hormonesCancer Risks and Factors

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Age at menarche and risk of all-cause and cardiovascular mortality: a systematic review and dose–response meta-analysis

Chen, Xu, Liu, Yu, Sun, Xizhuo, Yin, Zhaoxia, Li, Honghui, Liu, Xuejiao, Zhang, Dongdong, Cheng, Cheng, Liu, Leilei, Liu, Feiyan, Zhou, Qionggui, Wang, Chongjian, Li, Linlin, Wang, Bingyuan, Zhao, Yang, Liu, Dechen, Zhang, Ming, Hu, Dongsheng·2019·Menopause
DOI 10.1097/gme.0000000000001289
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Abstract

Objective: The evidence between age at menarche and mortality risk is controversial. We aimed to quantify the dose–response association of age at menarche and risk of all-cause and cardiovascular disease (CVD) mortality based on cohort studies. Methods: PubMed, EMBASE, Web of Science, and Scopus databases were searched up to March 15, 2018 for relevant articles. Random-effects models and restricted cubic splines were used for this meta-analysis. Results: Twelve cohort studies, with 79,363 deaths and 2,341,769 participants, met the inclusion criteria. With each 1-year increase in menarche age, the relative risk (RR) was reduced for all-cause mortality (RR: 0.977, 95% confidence interval [CI]: 0.970-0.984), CVD mortality (RR: 0.993, 95% CI: 0.975-1.011), ischemic heart disease (IHD) mortality (RR: 0.969, 95% CI: 0.947-0.993), and stroke mortality (RR: 0.983, 95% CI: 0.954-1.012). We found a nonlinear dose–response association ( P nonlinearity = 0.001) between age at menarche and all-cause mortality, with the lowest risk observed at menarche age 15 years (RR: 0.849 95% CI: 0.800-0.901), but no evidence of a nonlinear association between menarche age and CVD mortality ( P nonlinearity = 0.543), IHD mortality ( P nonlinearity = 0.310), or stroke mortality ( P nonlinearity = 0.824). Conclusions: Age at menarche is inversely associated with all-cause and IHD mortality.

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Crossref · 10.1097/gme.0000000000001289

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Research works printed but not linked: 1

  1. Prentice, 2013, Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis, Int J Obes (Lond), 37, 1036, 10.1038/ijo.2012.177 · DOI · Paper page

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Metadata

Authors
Chen, X., Liu, Y., Sun, X., Yin, Z., Li, H., Liu, X., Zhang, D., Cheng, C., Liu, L., Liu, F., Zhou, Q., Wang, C., Li, L., Wang, B., Zhao, Y., Liu, D., Zhang, M., & Hu, D.
Affiliations
  • Zhengzhou University (CN)
  • Shenzhen University Health Science Center (CN)
Corresponding author
Hu, Dongsheng
ORCID
Venue
Menopause
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-12-17
Volume
26
Issue
6
Pages
670-676
ISSN
  • 1072-3714 (ISSN-L)
  • 1530-0374
DOI
10.1097/gme.0000000000001289
OpenAlex
W2904593518
Cited by
68
References
37
Citations by year
2026: 5 · 2025: 10 · 2024: 10 · 2023: 15 · 2022: 12 · 2021: 7 · 2020: 6 · 2019: 3
FWCI
0.62
Type
journal article
Language
en
Open access
closed
Locations
  • Menopause The Journal of The North American Menopause Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
age at menarche, all-cause mortality, cardiovascular mortality, ischemic heart disease mortality, stroke mortality, dose-response relationship, nonlinear relationship, women's health
MeSH terms
Age Factors, Cardiovascular Diseases, Female, Humans, Menarche, Risk Factors

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