The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Premature menopause or early menopause and risk of ischemic stroke
Open accessAbstract
In Brief Objective The general consensus has been that estrogen is invariably a risk factor for ischemic stroke (IS). We reviewed new observational studies that challenge this simple conclusion. Methods This was a review of observational studies of the association of premature or early menopause with stroke or IS published in English from 2006 through 2010. Results Three cohort studies showed an increased risk of all types of stroke in women who underwent bilateral oophorectomy compared with women who conserved their ovaries before age 50 years. The increased risk of stroke was reduced by hormone therapy in one of the studies, suggesting that estrogen deprivation is involved in the association. Four additional observational studies showed an association of all types of stroke or IS with the early onset of menopause or with a shorter life span of ovarian activity. In three of the seven studies, the association was restricted to IS. Age at menopause was more important than type of menopause (natural vs induced). Conclusions The findings from seven recent observational studies challenge the consensus that estrogen is invariably a risk factor for IS and can be reconciled by a unifying timing hypothesis. We hypothesize that estrogen is protective for IS before age 50 years and may become a risk factor for IS after age 50 years or, possibly, after age 60 years. These findings are relevant to women who experienced premature or early menopause or to women considering prophylactic bilateral oophorectomy before the onset of natural menopause. The findings from seven recent observational studies challenge the consensus that estrogen is invariably a risk factor of ischemic stroke. In this study, a unifying theory is proposed, in which estrogen is protective before approximately age 50 years and may become a risk factor of ischemic stroke after age 50 years or, possibly, after age 60 years.
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“Treatment with estrogens until age 45 years or longer may reduce the risk of cardiovascular disease and mortality (47,49,51).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [49]
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“Treatment with estrogens through age 45 years or longer may reduce the risk of cardiovascular disease and mortality (47,49,51).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [49]
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Citations
Cites
The Protective Effects of Estrogen on the Cardiovascular System
Mendelsohn, M. E., & Karas, R. H. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402306 · Cited by 3,119
A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women
Ridker, P. M., Cook, N. R., Lee, I.-M., Gordon, D., Gaziano, J. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050613 · Cited by 1,945
Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause
Rossouw, J. E., Prentice, R. L., Manson, J. E., Wu, L., Barad, D., Barnabei, V. M., Ko, M., LaCroix, A. Z., Margolis, K. L., & Stefanick, M. L. (2007) · JAMA · doi:10.1001/jama.297.13.1465 · Cited by 1,741
Effect of Estrogen Plus Progestin on Stroke in Postmenopausal Women
Wassertheil-Smoller, S. W., Hendrix, S. L., Limacher, M. C., HEISS, G. M., Kooperberg, C. L., Baird, A. E., Kotchen, T. A., Curb, J. D., Black, H. R., Rossouw, J. E., et al. (2003) · JAMA · doi:10.1001/jama.289.20.2673 · Cited by 1,160
Molecular and Cellular Basis of Cardiovascular Gender Differences
Mendelsohn, M. E., & Karas, R. H. (2005) · Science · doi:10.1126/science.1112062 · Cited by 1,105 · cited 2×
“Because estrogen induces several beneficial antiatherogenetic and vasoprotective effects as well as detrimental prothrombotic and proinflammatory effects, it might modify the risk of IS differentially, based on IS subtype.(13,33,34) In addition, the balance of these differential effects might vary with age.”
BackgroundNational Use of Postmenopausal Hormone Therapy
Hersh, A. L., Stefanick, M. L., & Stafford, R. S. (2004) · JAMA · doi:10.1001/jama.291.1.47 · Cited by 984
Premature menopause or early menopause: Long-term health consequences
Shuster, L. T., Rhodes, D. J., Gostout, B. S., Grossardt, B. R., & Rocca, W. A. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.08.003 · Cited by 845 · cited 3×
“4 y).(16,17) Premature menopause or early menopause can be spontaneous or induced; if induced, it can be due to medical Received April 4, 2011; revised and accepted June 22, 2011.”
BackgroundSelf-citationVos, M. D., Devroey, P., & Fauser, B. C. J. M. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60355-8 · Cited by 781
Petty, G. W., Brown, R. D., Whisnant, J. P., Sicks, J. D., O’Fallon, W. M., & Wiebers, D. O. (1999) · Stroke · doi:10.1161/01.str.30.12.2513 · Cited by 729 · cited 7×
“Under this hypothesis, the different risks of stroke and coronary heart disease associated with HT at ages 50 to 59 years may be, in part, due to the differential mechanisms of cardioembolic IS.(31,32)”
BackgroundInfluentialSelf-citationEstrogen Therapy and Coronary-Artery Calcification
Manson, J. E., Allison, M. A., Rossouw, J. E., Carr, J. J., Langer, R. D., Hsia, J., Kuller, L. H., Cochrane, B. B., Hunt, J. R., Ludlam, S. E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa071513 · Cited by 711
An evidence‐based causative classification system for acute ischemic stroke
Ay, H., Furie, K. L., Singhal, A. B., Smith, W. S., Sorensen, A. G., & Koroshetz, W. J. (2005) · Annals of Neurology · doi:10.1002/ana.20617 · Cited by 674 · cited 2×
“Ischemic versus hemorrhagic stroke Stroke is generally classified as ischemic, including embolic and thrombotic mechanisms, or hemorrhagic, including subarachnoid or intracerebral locations.(28,29) Because the pathogenetic mechanisms of ischemic and hemorrhagic stroke are different, we might expect different effects o…”
BackgroundParker, W. H., Broder, M. S., Chang, E., Feskanich, D., Farquhar, C., Liu, Z., Shoupe, D., Berek, J. S., Hankinson, S., & Manson, J. E. (2009) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e3181a11c64 · Cited by 640
Vascular Actions of Estrogens: Functional Implications
Miller, V. M., & DUCKLES, S. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.08002 · Cited by 608
Self-citationConjugated Equine Estrogens and Coronary Heart Disease
Hsia, J. A. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.3.357 · Cited by 607
LaCroix, A. Z. (2011) · JAMA · doi:10.1001/jama.2011.382 · Cited by 538
Increased cardiovascular mortality after early bilateral oophorectomy
Rivera, C. M., Grossardt, B. R., Rhodes, D. J., Brown, R. D., Roger, V. L., Melton, L. J., & Rocca, W. A. (2009) · Menopause · doi:10.1097/gme.0b013e31818888f7 · Cited by 481 · cited 12×
“For women aged 50 to 59 years, oral estrogen at a dose equivalent to 0.625 mg/day of conjugated estrogens is possibly beneficial for coronary heart disease but is a risk factor of IS.12 14 By contrast, for women who underwent premature or early menopause, oral estrogen taken before age 50 years may be safe and benefic…”
BackgroundInfluentialSelf-citationEstrogen replacement therapy, atherosclerosis, and vascular function
Mikkola, T. S. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00466-7 · Cited by 423
Estrogen and progestogen use in postmenopausal women
Utian, W. H., Archer, D. F., Bachmann, G. A., Gallagher, C., Grodstein, F., Heiman, J. R., Henderson, V. W., Hodis, H. N., Karas, R. H., Ra, L., et al. (2008) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31817b076a · Cited by 372
Effects of Conjugated Equine Estrogen on Stroke in the Women’s Health Initiative
Hendrix, S. L., Wassertheil-Smoller, S. W., Johnson, K., Howard, B. V., Kooperberg, C. L., Rossouw, J. E., Trevisan, M., Aragaki, A. K., Baird, A. E., Bray, P. F., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.594077 · Cited by 359
Changes in the Use of Postmenopausal Hormone Therapy after the Publication of Clinical Trial Results
Haas, J. S., Kaplan, C. P., Gerstenberger, E. P., & Kerlikowske, K. M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-3-200402030-00009 · Cited by 314
Estrogen and progestogen use in postmenopausal women
(2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181d0f6b9 · Cited by 265
Chambliss, K. L., Wu, Q., Oltmann, S. C., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G. D., Mineo, C., Yuhanna, I. S., Kim, S. H., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38291 · Cited by 249
Association between hormone replacement therapy and subsequent stroke: a meta-analysis
Bath, P. M., & Gray, L. J. (2005) · BMJ · doi:10.1136/bmj.38331.655347.8f · Cited by 234 · cited 1×
“The same conclusion was reached by three meta-analyses of clinical trials of HT and risk of stroke.(2,5,7)”
Age at Natural Menopause and Risk of Ischemic Stroke
Lisabeth, L. D., Beiser, A., Brown, D. L., Murabito, J. M., Kelly‐Hayes, M., & Wolf, P. A. (2009) · Stroke · doi:10.1161/strokeaha.108.542993 · Cited by 230 · cited 2×
“The increased risk associated with early natural menopause was limited to IS in the Framingham cohort study.(22) The association with early natural or surgical menopause was stronger for IS than for all types of stroke combined in one of the Japanese cohort studies (157% increase vs 56% increase).”
BackgroundNeuroprotective effects of estrogens following ischemic stroke
Suzuki, S., Brown, C. M., & Wise, P. M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.007 · Cited by 223
Hormone Therapy Prescribing Patterns in the United States
Buist, D. S. M., Newton, K. M., Miglioretti, D. L., Beverly, K., Connelly, M. T., Andrade, S., Hartsfield, C. L., Wei, F., Chan, K. A., & Kessler, L. G. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000143826.38439.af · Cited by 213
Hysterectomy and risk of cardiovascular disease: a population-based cohort study
Ingelsson, E., Lundholm, C., Johansson, A. L. V., & Altman, D. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq477 · Cited by 200 · cited 3×
“Finally, a recent nationwide Swedish cohort study showed a 47% increased risk of stroke in women who underwent hysterectomy plus bilateral oophorectomy before age 50 years compared with women who did not have either of the surgeries.(24)”
BackgroundMethodPostmenopausal Hormone Therapy and Stroke
Grodstein, F., Manson, J. E., Stampfer, M. J., & Rexrode, K. M. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.8.861 · Cited by 191 · cited 9×
“For women aged 50 to 59 years, oral estrogen at a dose equivalent to 0.625 mg/day of conjugated estrogens is possibly beneficial for coronary heart disease but is a risk factor of IS.12 14 By contrast, for women who underwent premature or early menopause, oral estrogen taken before age 50 years may be safe and benefic…”
BackgroundInfluentialSare, G. M., Gray, L. J., & Bath, P. M. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn299 · Cited by 190
Oophorectomy vs Ovarian Conservation With Hysterectomy
Jacoby, V. L., Grady, D. G., Wactawski‐Wende, J., Manson, J. E., Allison, M., Kuppermann, M., Sarto, G. E., Robbins, J. A., Phillips, L. S., Martin, L. W., et al. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.121 · Cited by 188 · cited 2×
“A new cohort study conducted as part of the WHI Observational Study was published in 2011 and is outside the time frame of this formal review (2006-2010).(25) The results are summarized here for completeness.”
BackgroundMethodEffect of Bilateral Oophorectomy on Women's Long-Term Health
Parker, W. H., Jacoby, V., Shoupe, D., & Rocca, W. (2009) · Women's Health · doi:10.2217/whe.09.42 · Cited by 161 · cited 2×
“The studies summarized in Table 1 and Figure 1 suggest that the increased risk of stroke or IS is observed both for women who underwent premature or early natural menopause(18,19,22,23) and for women who underwent bilateral oophorectomy.(15,21,23,24)”
BackgroundMethodSelf-citationEMAS position statement: Managing women with premature ovarian failure
Vujović, S., Brincat, M., Erel, C. T., Gambacciani, M., Lambrinoudaki, I. V., Moen, M. H., Schenck-Gustafsson, K. G., Trémollières, F., Rozenberg, S., & REES, M. C. P. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.04.011 · Cited by 147 · cited 1×
“Second, women who experienced an early estrogen deficiency state before approximately age 45 years, either naturally or because of medical or surgical interventions, should consider taking HT, unless there is a clear contraindication.(16,48,49) Unfortunately, the results from the WHI clinical trials have been inapprop…”
BackgroundRocca, W. A., Shuster, L. T., Grossardt, B. R., Maraganore, D. M., Gostout, B. S., Geda, Y. E., & Melton, L. J. (2009) · Women s Health · doi:10.2217/17455057.5.1.39 · Cited by 144
Self-citationEstradiol and G1 Reduce Infarct Size and Improve Immunosuppression after Experimental Stroke
Zhang, B., Subramanian, S., Dziennis, S., Jia, J., Uchida, M., Akiyoshi, K., Migliati, E., Lewis, A. D., Vandenbark, A. A., Offner, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902339 · Cited by 127
Mendelsohn, M. E., & Karas, R. H. (2007) · New England Journal of Medicine · doi:10.1056/nejme078072 · Cited by 123 · cited 2×
“Because estrogen induces several beneficial antiatherogenetic and vasoprotective effects as well as detrimental prothrombotic and proinflammatory effects, it might modify the risk of IS differentially, based on IS subtype.(13,33,34) In addition, the balance of these differential effects might vary with age.”
BackgroundCui, R., Iso, H., Toyoshima, H., Date, C., Yamamoto, A., Kikuchi, S., Kondo, T., Watanabe, Y., Koizumi, A., Inaba, Y., et al. (2006) · Journal of Epidemiology · doi:10.2188/jea.16.177 · Cited by 120 · cited 1×
“However, neither of these hazard ratios was statistically significant.(18) A Spanish case-control study of noncardioembolic IS showed a 51% increased odds ratio for a shorter life span of ovarian activity (G34 y between menopause and menarche).”
BackgroundIncidence Rates of First-Ever Ischemic Stroke Subtypes Among Blacks
Woo, D., Gebel, J., Miller, R., Kothari, R., Brott, T. G., Khoury, J. C., Salisbury, S. R., Shukla, R., Pancioli, A., Jauch, E. C., et al. (1999) · Stroke · doi:10.1161/01.str.30.12.2517 · Cited by 119 · cited 7×
“Under this hypothesis, the different risks of stroke and coronary heart disease associated with HT at ages 50 to 59 years may be, in part, due to the differential mechanisms of cardioembolic IS.(31,32)”
BackgroundInfluentialRisk of ischemic stroke and lifetime estrogen exposure
de Leciñana, M. A., Egido, J. A., Fernández, C., Martínez‐Vila, E., Santos, S. S., Morales, A., Martínez, E., Pareja, A., Álvarez‐Sabín, J., & Casado, I. (2007) · Neurology · doi:10.1212/01.wnl.0000250238.69938.f5 · Cited by 116 · cited 2×
“The association with a shorter life span duration of ovarian activity was also limited to IS in the Spanish case-control study.(19) In summary, the association seems to be restricted to IS in studies that considered IS separately from hemorrhagic stroke.”
BackgroundAnderson, C. S., Chakera, T., Stewart‐Wynne, E. Q., Jamrozik, K. D., Burvill, P. W., & Johnson, G. A. (1993) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1993.tb137529.x · Cited by 114 · cited 1×
“Ischemic versus hemorrhagic stroke Stroke is generally classified as ischemic, including embolic and thrombotic mechanisms, or hemorrhagic, including subarachnoid or intracerebral locations.(28,29) Because the pathogenetic mechanisms of ischemic and hemorrhagic stroke are different, we might expect different effects o…”
BackgroundAdvancing the Study of Stroke in Women
Bushnell, C., Hurn, P. D., Colton, C. A., Miller, V. M., del Zoppo, G., Elkind, M. S. V., Stern, B. J., Herrington, D. M., Ford-Lynch, G., Gorelick, P. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000236053.37695.15 · Cited by 102
Self-citationEstrogen and Mitochondria: A New Paradigm for Vascular Protection?
DUCKLES, S. P. (2006) · Molecular Interventions · doi:10.1124/mi.6.1.6 · Cited by 95
Mack, W. J., Slater, C. C., Xiang, M., Shoupe, D., Løbo, R. A., & Hodis, H. N. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.01.034 · Cited by 87
Rapid progress for non-nuclear estrogen receptor signaling
Mendelsohn, M. E., & Karas, R. H. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43756 · Cited by 79
Systematic review: Hormone therapy and cardiovascular disease: a systematic review and meta‐analysis
Magliano, D. J., Rogers, S., Abramson, M. J., & Tonkin, A. M. (2005) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00797.x · Cited by 70
Premature menopause is associated with increased risk of cerebral infarction in Japanese women
Baba, Y., Ishikawa, S., Amagi, Y., Kayaba, K., Gotoh, T., & Kajii, E. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181c7dd41 · Cited by 62
Prospective Study of Endogenous Circulating Estradiol and Risk of Stroke in Older Women
Lee, J. S. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.322 · Cited by 61
Oestrogen and stroke in women: assessment of risk
Bushnell, C. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70220-9 · Cited by 55
Long-term impact of the women’s health initiative on HRT
Parente, L., UYEHARA, C. F. T., Larsen, W. I., Whitcomb, B. P., & Farley, J. H. (2007) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-007-0442-1 · Cited by 39
Practice patterns with hormone therapy after surgical menopause
Chubaty, A. J., Shandro, M. T. L., Schuurmans, N., & Yuksel, N. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.02.004 · Cited by 35
Oophorectomy and cardiovascular mortality
Parker, W. H., & Manson, J. E. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31818d64d6 · Cited by 32 · cited 8×
“For women aged 50 to 59 years, oral estrogen at a dose equivalent to 0.625 mg/day of conjugated estrogens is possibly beneficial for coronary heart disease but is a risk factor of IS.12 14 By contrast, for women who underwent premature or early menopause, oral estrogen taken before age 50 years may be safe and benefic…”
BackgroundMethodInfluentialRaval, A. P., Bhatt, A., & Saul, I. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.021 · Cited by 24 · cited 1×
“Additional biological mechanisms specific for the protection of neuronal or glial cells against brain ischemia have also been reviewed elsewhere.(45,46) These beneficial effects of estrogen are probably acting over the full life span of women, so that an adequate amount of endogenous or exogenous estrogen early in lif…”
BackgroundShort-term Use of Unopposed Estrogen
Jungheim, E. S. (2011) · JAMA · doi:10.1001/jama.2011.405 · Cited by 17 · cited 1×
“7 years of follow-up.(36,37) In addition, women experienced a significantly decreased risk of breast cancer.”
BackgroundSILVERMAN, B. G., & Kokia, E. S. (2009) · Annals of Pharmacotherapy · doi:10.1345/aph.1l438 · Cited by 12
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BackgroundMuka, T., Oliver-Williams, C., Kunutsor, S., Laven, J. S. E., Fauser, B. C. J. M., Chowdhury, R., Kavousi, M., & Franco, O. H. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.2415 · Cited by 826
Metadata
- Authors
- Rocca, W. A., Grossardt, B. R., Miller, V. M., Shuster, L. T., & Brown, R. D.
- Affiliations
- Mayo Clinic (US)
- Department of Medical Sciences (BY)
- Corresponding author
- Rocca, Walter A.
- Venue
- Menopause
- Published
- 2012-03
- Volume
- 19
- Issue
- 3
- Pages
- 272-277
- ISSN
- 1072-3714 (ISSN-L)
- PMC
- PMC3258468
- OpenAlex
- W2016373832
- Semantic Scholar
- 5046b0fb75f713a0ec75734faf7bbf9842dc66db
- Cited by
- 188
- References
- 53
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 12 · 2022: 5 · 2021: 10 · 2020: 11 · 2019: 31 · 2018: 11 · 2017: 14 · 2016: 15 · 2015: 11 · 2014: 17 · 2013: 13 · 2012: 12
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Menopause The Journal of The North American Menopause Society (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG034676, AG-034676)
- National Institute of Neurological Disorders and Stroke (NS 033978, R01NS033978)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- premature menopause, early menopause, ischemic stroke, estrogen, estrogen deprivation, bilateral oophorectomy, hormone therapy, timing hypothesis, ovarian function
- MeSH terms
- Female, Humans, Menopause, Premature, Ovariectomy, Risk, Cohort Studies, Hormone Replacement Therapy, Stroke
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